Wound infection corticosteroids

Adverse reactions associated with administration of the corticosteroid ophthalmic preparations include elevated IOP with optic nerve damage, loss of visual acuity, cataract formation, delayed wound healing, secondary ocular infection, exacerbation of comeal infections, dry eyes, ptosis, blurred vision, discharge, ocular pain, foreign body sensation, and pruritus. 

If mast cell stabilizers or multiple-action agents are not successful, a trial of a topical NSAID is appropriate. Ketorolac is the only approved topical agent for ocular itching. NSAIDs do not mask ocular infections, affect wound healing, increase intraocular pressure, or contribute to cataract formation like the topical corticosteroids. However, for allergic conjunctivitis, topical ketorolac is not as effective as olopatadine or emedas-tine in trials.15 Full efficacy of ketorolac takes up to 2 weeks.17... 

In immunocompromised patients and patients receiving corticosteroids, both the symptoms of intraabdominal infections are attenuated and the resolution of infection is impaired. Patients with poor nutritional status (both over- and under-weight) or other causes of poor wound healing (cigarette smoking) are prone to complications. 

Topical antibacterial agents are used to prevent infection and in the early treatment of infected dermatoses and wounds. Various preparations contain corticosteroids in addition to antibacterial agents. 

Corticosteroids Decreased epithelial wound healing, increased risk for infection (decreased tear lysozyme)... 

Treatment is symptomatic and supportive. The wound should be cleaned with soap and water tetanus prophylaxis should be administered. Application of ice packs or the topical application of a corticosteroid, antihistamine, or local anesthetics may be useful in relieving symptoms. Severe pain has been treated with injection of a local anesthetic. Antibiotics are reserved for documented infections. 

Zinc Dermatitis, hypogeusia, alopecia, diarrhea, apathy, depression, growth retardation, impaired wound healing, immunosuppression Acute gastric distress, nausea, dizziness, death with large intravenous doses Chronic immunosuppression, decreased HDL, copper deficiency Decreased infection, hypoalbuminemia, corticosteroids, pregnancy, burns, stress, inflammation Increased tissue injury, hemolysis, contaminated collection tube... 

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