Whitehead Institute

Whitehead Institute/MIT Center for Genome Research http // www.genome.wi.mit.edu/... 

Warfarin, 165 Wellcome Trust, 30,147 Whitehead Institute for Biomedical Research (MIT), 126 Whites... 

Karolinska Institute National Institutes of Health Nature Genetics Orchid Biocomputer Pharsight Corporation SNP Consortium Stanford University Whitehead Institute... 

Department of Biology Massachusetts Institute of Technology Whitehead Institute for Biomedical Research Howard Hughes Medical Institute Research Laboratories Cambridge, Massachusetts... 

CellProfiler and CellProfiler Analyst are free Open Source software for automated image analysis, data visualization, and machine learning. Versions for Mac, Windows, and Linux are available and both software can be downloaded at http //www.cellprofiler. org. CellProfiler was developed by Anne Carpenter and Thouis Jones in the laboratory of David Sabatini at the Whitehead Institute for Biomedical Research and by Polina Golland at the CSAIL of the MIT. 

Figure 8.16. PlateTrak, automated microplate processing system developed by PerkinElmer in collaboration with the Whitehead Institute for Biomedical Research. (Reprinted with permission from Ref. 30.)...

Molecular Probe Database Primer3, Whitehead Institute/MIT... 

Whitehead Institute for Biomedical Research Washington University School of Medicine Stanford Human Genome Center Cold Spring Harbor Laboratory... 

For the Human Genome Project some 16 international centers participated, with the Whitehead Institute at MIT in Cambridge, Massachusetts, taking a strong role in the United States. But it was freelancer J. Craig Venter, the wild... 

Recall that the official completion of the human genome was on June 26, 2000. According to Jill Mesirov at the Whitehead Institute, a major center for the project, the working draft at that time was estimated to have 99.9% accuracy with 97% assembled mapped clones and 85% assembled DNA sequences, a total of 2.6 billion base pairs sequenced. About 90% of known genes was found in the first draft. More completion took place in 2003 with repeated coverage... 

The importance of all this research is that it leads to (or gives ideas about) smaller and ever more intelligent biochips in our bodies, including our brains. Susan Lindquist, director of the MIT Whitehead Institute for Biomedical Research, is working on very small computer chips. She is doing the requisite nanotechnology for this with the help of aberrant shapes of proteins, the prions that are responsible for mad cow disease and Creuzfeldt-Jacob disease in... 

In work nnder way at the Whitehead Institute for Biomedical Research in Boston by researcher Matthew Meyerson, a gene called human Ever Shorter Telomeres 2, or hEST2, has been fonnd responsible for making a component of telomerase. Thus, it may very well be a key agent that switches on uncontrolled cellular growth.)... 

The effect was ultimately thought to be due to the presence of a relatively small number of a particular kind of active cell, denoted as a stem cell. For the record, the Academic Press Dictionary of Science and Technology defines a stem cell as a cell, capable of both indefinite proliferation and differentiation into specialized cells, that serves as a continuous source of new cells for such tissues as blood and testes. Cancer biologist Robert Weinberg of the Whitehead Institute, Cambridge, Massachusetts, and discoverer of the first human oncogene, is quoted in the article as follows. Within a tumor mass, there is only a small population of cells that can spawn more tumor other cells in the tumor cannot. ... 

The effect of mutations on Drosophila development. Scanning electron micrographs of the eye from lef a wild-type fly, (middle) a fly carrying a dominant developmental mutation produced by recombinant DNA methods, and (right) a fly carrying a suppresor mutation that partially reverses the effect of the dominant mutation. [Courtesy of llaria Rebay, Whitehead Institute, MIT]... 

John E. Kinsella and Dana M. Whitehead Institute of Food Science, Cornell University, Ithaca, NY 14853... 

The Whitehead Institute/MIT Center for Genome Research constructed a map with approximately 6,000 markers using the GB4 panel (Hudson et al., 1995). Framework markers on this map were localized with odds >300 1, yielding a resolution of approximately 2.3 Mb between framework markers. Additional markers are localized to broader map intervals. A mapping server is provided for placing markers (scored in the GB4 panel) relative to the MIT maps. 

An initial 7.5 million will be used for biology department funding and to help defray administration costs another 20 million will be provided to build the Whitehead Institute of Biomedical Research near Cambridge, Massachusetts. The institute will function under a 60 million trust that will supply 5 million annually for operating expenses at or before Whitehead s death, the institute will receive 100 million, less funds already laid out from the trust. 

Compiled from David Baltimore, director, Whitehead Institute, personal communication Newsweek, October 12, 1981 Inside R D, December 16, 1981 Washington Post, October 2, 1981 Science, June 5, 1981. 

Reports on the debate in the MIT community about the proposed establishment of the Whitehead Institute for Biomedical Research with a unique affiliation between the institute and MIT. Mr. Edwin C. Whitehead, a self-made millionaire, proposed to spend 20 million to build and equip the institute, provide 5 million a year in operating funds, and leave an endowment of 100 million when he dies. He characterized the proposed institute as "a purely philanthropic enterprise."... 

Figure 3. A 6-plex PCR multiplexed by designing primers differing in length by 2 T residues. PCR primers and genotyping primers were designed for the following loci from the Whitehead Institute Centre for Genome Research SNP database WIAF 445, WIAF135, WIAF 2083, WIAF 1970, WIAF 1438, and WIAF 1243.

Several websites offer to perform many of the preceding activities for you. A very useful one was designed at the Whitehead Institute. The siRNA prediction program can be found under Tools at http //jura.wi.mit.edu/bio/. Similar programs are offered by companies (see Note 3). 

Department of Biology Whitehead Institute/MIT Cambridge, Massachusetts 02142... 

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