Whitehead

The behavior in the presence of air is quite different. For example, Tingle [22] found that the friction between copper surfaces decreased from a fi value of 6.8 to one of 0.80 as progressive exposure of the clean surfaces led to increasingly thick oxide layers. As noted by Whitehead [23], several behavior patterns... 

L. Whitehead and co-workers, paper presented at MHD Contractors Review Meeting Pittsburgh, Pa., Nov. 1983. 

Primary synthesis has limited application in making pyrimidine-carboxylic acids or even their esters. However, some pyrimidine-4(and 5)-carboxylic acids can be effectively so made. For example, bromomucic acid (785) reacts as an aidehydo ketone with S-methyl-thiourea to give 5-bromo-2-methylthiopyrimidine-4-carboxylic acid (786) directly (53JCS3129) while the Whitehead synthesis (Section 2.13.3.1.2<7) can give, for instance, 3-methylcytosine-5-carboxylic acid (787) (55MI21300). 

Purified by TLC on silica gel with EtOAc-pet ether (b 60-80°) (15 85), and recrystallised from MeOH or CgH6. [NMR Wamhoff Can J Chem 42 1664 1964, Ramage and Whitehead J Chem Soc 4336 1954.]... 

Tetrahydrothiophene [110-01-0] M 88.2, m -96 , b 14.5 /10mm, 120.9 /760mm, d 0.997, n 1.5289. Crude material was purified by crystn of the mercuric chloride complex to a constant melting point. It was then regenerated, washed, dried, and fractionally distd. [Whitehead et al. 7 Am Chem Soc 73 3632 7957.] It has been dried over Na2S04 and distd in a vacuum [Roberts and Friend J Am Chem Soc 108 7204 1986]. 

So, physical chemistry has developed far beyond the vision of its three famous founders. But then, the great mathematician A.N. Whitehead once remarked that a science which hesitates to forget its founders is lost he meant that it is dangerous to refuse to venture in new directions. Neither physical chemistry nor materials science has ever been guilty of such a refusal. 

Weston, L. M., D.W. Whitehead, and N. L.Graves, Recovery Actions in PRA for the Risk Methods Integration and Evaluation Program (RMIEP) Volume I Development of the Databascd Method, June 1987. 

That the methyl group in the pyrrolidine enamine of 2-methylcyclo-hexanone (7) is in fact axial was demonstrated by Johnson and Whitehead (8). They found that careful hydrolysis of the pyrrolidine enamine of the conformationally more stable system, i.e., 2-methyI-4-t-butylcyclohexanone (13), led to a 1 4 mixture of cis and trans isomers of the ketone (14 and 15), showing that the methyl group in the enamine is largely in the axial orientation. 

Johnson and Whitehead have further shown that the reductive elimination of the pyrrolidine group from the pyrrolidine enamine of 2,4-dimethyl-cyclohexanone (16), which involved treating it with a mixture of lithium aluminum hydride and aluminum chloride (9), gave the trans isomer of 3,5-dimethyl-/l -cyclohexene (17) which on subsequent hydrogenation on a platinum catalyst led to the // onr-3,5-dimethylcyclohexane (18). 

---