Warm-blooded animals

Fecal Goliforms. Eecal coliforms are those originating from the intestines of warm-blooded animals. Eecal coliforms can be deterrnined by a multiple-tube procedure, which must be appHed to a positive presumptive test for optimum recovery of fecal coliforms (20). Incubation must be at 44.5 0.2°C for 24 2 h. Gas production during incubation is positive evidence of fecal coliform poUution. 

Worms - There are three types of worms found in water. For the most part, they dwell in the bed of the material at the bottom of lakes and streams. There they do important work as scavengers. The rotifiers are the only organisms in this category at or near the surfaee. They live primarily in stagnant fresh water. The eggs and larvae of various intestinal worms found in man and warm-blooded animals pollute the water at times. They do not generally cause widespread infection for several reasons. They are relatively few in number and are so large they can be filtered out of water with comparative ease. 

Humans and the other warm-blooded animals have developed thermoregulatory systems to carefully control body temperature to levels that enable them to function and survive effectively. In general, thermal comfort occurs when the physiological effort to control body temperature is minimized for the activity. Table. 5.1... 

According to Georgadze the three sophora alkaloids sophocarpine (a), sophocarpidine (h) and sophoridine (c) only differ in degree and not in character of their pharmacological activity thus on intravenous injection each causes a rise and then a fall i i blood pressure and their activity in this direction is in decreasing order (a), (c), (b). In small doses they stimulate, and in larger doses depress, the isolated heart of either cold- or warm-blooded animals and then their decreasing order of activity is (c), (b), (a). 

Warmbluter, m.pl. warm-blooded animals. warm-blUtig, a. warm-blooded, hematothermal. -briichig, a. (Metal.) hot-short, brittle when hot. 

Many other topics in addition to those covered by the titles in these symposia were proposed, and may form the basis for future symposia. Other suggestions included the broad and important topic of formulation, which may many times have an important relation to the effectiveness of the economic poison for the purpose for which it is designed, may be modified to prepare a given pesticide for different uses, and may also influence its toxicity to warm-blooded animals. A report of work on methods of application and their relation to effectiveness was suggested, including much work on the use of concentrated sprays. 

Complete safety for man and other warm-blooded animals... 

As the value of these two new chemicals for insecticides became more evident, the need for extended experimental and test work was definitely established. It was necessary to determine chemical formulas, work out analytical methods, obtain knowledge of various physical and chemical characteristics, and complete evaluation of insecticidal action as well as toxicity and effect of residues. Toxicity was concerned with not only insects but humans and other warm-blooded animals. Residual studies included information on persistence and type and amount of residue. This information, once accumulated, must be correlated with similar information on other insecticides. 

The chemist must work with the entomologist, the toxicologist, and others concerned in the formulation of new and better insecticides, or in the improvement of old ones. All formulations must be tested to determine their insecticidal efficiency, as well as their toxicity to warm-blooded animals, before manufacture on a large scale is begun. 

For some important insect pests there are still no satisfactory chemical controls. Such problems should be given due consideration in the development program. Many of these problems appeared to be solved with the discovery of DDT, benzene hexachlo-ride (hexachlorocyclohexane), and some of the more recent insecticides. Further studies of the toxicity of some of these products to warm-blooded animals have raised the important question of the advisability of continuing their use where food and feed products are concerned. Considerable attention is being centered on finding safer analogs, such as TDE and methoxychlor, and new and better insecticides. 

Geigy s mothproofing agent was a stomach poison for moths and other keratin-eating insects. It had a strong affinity for woolens, was harmless to warm-blooded animals and people, and had no offensive odor. As a chlorinated hydrocarbon, it was extremely persistent despite exposure to light and moisture. 

Thus it is significant that for such si/m-triazine herbicides as simazine, atrazine, etc., the health and hygiene MPC (toxicity to warm-blooded animals, including humans) and phytotoxic MPC (toxicity to plants) differ by more than an order of magnitude 0.2-0.5 mg/kg for warm-blooded animals, and 0.01 mg/ kg for plants [89]. Warm-blooded animals and arthropods have a difference in sensitivity to many pyretroids that can reach tens of thousands of times [90]. 

Warm-blooded animals As for (4) with temperature controls. 

It is present in most of Europe, throughout Africa, the Middle East, most of Asia, and the Americas. It is a highly lethal disease that can affect all warm-blooded animals. This is a biosafety level 2 agent unless there is a high risk of aerosol production then it should be treated as a biosafety level 3 agent. 

Table 12.6 Acute Aerosol Inhalation Toxicity of Carbofuran to Warm-Blooded Animals...

On the basis of evidence presented herein, this author conservatively estimates that, in terms of total carbofuran in water, damage is possible to aquatic invertebrates at >2.5 pg/L and to teleosts at >15 pg/L. These levels could be attained during a heavy rainfall shortly after carbofuran treatment of adjacent fields. Among sensitive species of warm-blooded animals, dietary concentrations as low as 10 pg/kg ration have demonstrable effects, which were measurable only after extended periods postingestion. For comparison, this level is about 1/5 that allowed in meat by-products for... 

Chlordane produced before 1951 contained a significant quantity of hexachlorocyclopentadiene — a toxic irritant to warm-blooded animals. Chlordane produced since 1951 contains little or none of this compound (Ingle 1965). A high-purity chlordane formulation containing about 74% cis-chlordane and 24% fims-chlordane is also available (Nomeir and Hajjar 1987). 

Chlordane is readily absorbed by warm-blooded animals through skin, diet, and inhalation. It is quickly distributed in the body and tends to concentrate in liver and fat (WHO 1984). Up to 75% of a single oral dose of chlordane administered to rats and mice was absorbed in the gut, and up to 76% of an aerosol dose was absorbed in the respiratory tract (Nomeir and Hajjar 1987). Rabbits absorbed 33% in the gut following oral administration (USEPA 1988). Chlordane residues in mammals were usually not measurable 4 to 8 weeks after cessation of exposure (Ingle 1965). Chlordane persistence in human serum and whole body was estimated at 88 days and 21 days, respectively this compares to a Tb 1/2 of about 23 days in rats fed chlordane for 56 days (USEPA 1980). 

Chlordane is readily absorbed by warm-blooded animals via skin, diet, and inhalation, and distributed throughout the body. In general, residues of chlordane and its metabolites are not measurable in tissues 4 to 8 weeks after exposure, although metabolism rates varied significantly between species. Food chain biomagnification is usually low, except in some marine mammals. In most mammals, the metabolite oxychlordane has proven much more toxic and persistent than the parent chemical. 

Adverse effects of fenvalerate on survival of terrestrial arthropods were observed at 0.002 to 0.015 pg whole-body topical application, O.llkg/ha aerial application, 5.4 mg/kg in the soil, 50 mg/kg in the diet, and 1.4 g/ant mound (Table 20.4). Synthetic pyrethroids are more effective in biological systems at low temperatures. The relative sensitivity of insects when compared with mammals is attributed in part to this negative temperature coefficient. Thus, warm-blooded animals are less affected than insects and other poikilotherms (Klaassen etal. 1986). Fenvalerate, for example, showed a negative correlation between temperature and toxicity to crickets (Acheta pennsylvanicus), being up to 1.9 times more toxic at 15°C than at 32°C (Harris etal. 1981). A similar case is made for honey bees (Apis mellifera) (Mayer et al. 1987) and for many species of aquatic invertebrates and fish (Mayer 1987). 

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