Viruses asthma caused

Human rhinoviruses (HRV) are members of the Picornaviridae family. The HRVs are classified according to their receptor specificity into members of the major and minor groups. The 87 members of the major-group viruses bind to the intracellular adhesion molecule receptor 1 (ICAM-1), whereas the 12 serotypes of the minor group bind to members of the low-density lipoprotein receptor family (LDLR) [42]. Rhinoviruses cause more than a billion cases of the common cold each year and are also associated with asthma exacerbations [43,44]. Statistically, one encounters one to three infections per year on the average [45]. As a result, rhinoviral infections are responsible for 25 million days of missed work in the USA [46]. 

Uses Chronic asthma Actions Topical steroid Dose Two inhalations tid-qid or 4 inhal bid Caution [C, ] Contra Component aU gy Disp Met-dose inhaler SE Cough, oral candidiasis Interactions T Risk of GI bleed W/ ASA, NSAIDs T effects W/ sakneterol, troleandomycin -1- effects W/barbiturates, hydantoins, pheny-toin, rifampin T effects OF diuretics, insulin, oral hypoglycemics, K supl, salicylates, somatrem, live virus vaccines EMS May affect glucose(hyperglycemia) monitor ECG for hypokalemia (flattened T waves) concurrent ASA/NSAID use may t risk of GI bleeding OD Acute OD unlikely to cause life-threatening Sxs, chronic OD may lead to S/Sxs of muscle weakness, and osteoporosis symptomatic and supportive... 

Some early respiratory infections, e.g. pertussis and bronchiolitis caused by respiratory syncytial virus, as well as some forms of gastro-enteritis may enhance the development of allergic diseases and asthma. 

Viral infections are primarily responsible for exacerbations of asthma. Viral upper respiratory tract infections are a major precipitant of acute asthma in children, being involved in up to 20% to 40% of acute episodes. Infants are particularly susceptible to airways obstruction and wheezing with viral infections because of their small airways. The most common cause of exacerbations in both children and adults is the common rhinovirus." Other viruses isolated include respiratory syncytial virus (RSV), parainfluenza virus, coronavirus, and influenza viruses. The inflammatory response to viral infection is thought to be associated directly with the increasing BHR. Certain viruses (RSV and parainfluenza virus) are capable of inducing spe-... 

The exacerbation of asthmatic responses is most frequently caused by a pulmonary viral infection, such as influenza, rhino, or adenovirus infections (81-89). Recent data has indicated that rhinoviral infections are the most common cause of severe asthma exacerbations. In addition to exacerbating asthmatic responses, severe respiratory syncytial virus (RSV) infections early in childhood appears... 

Respiratory viral infections, including adenovirus, influenza, metapneumovirus, parainfluenza, rhinovirus, and respiratory syncytial virus (RSV), are the primary cause of asthma exacerbations in both children and adults... 

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