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Virus neutralization

Zhang PF, Bouma P, Park EJ, et al. A variable region 3 (V3) mutation determines a global neutralization phenotype and CD4-independent infectivity of a human immunodeficiency virus type 1 envelope associated with a broadly cross-reactive, primary virus-neutralizing antibody response. J Virol 2002 76(2) 644-655. [Pg.282]

Rabies virus glycoprotein (G)and nucleo-protein (N) Alfala mosaic virus and tobacco mosaic vims in tobacco and spinach leaf Elicited specific virus-neutralizing antibodies in mice. Immunogenic in mice when delivered orally and parenterally immunogenic in humans when delivered orally. Moderately protective against lethal challenge infection in mice. 16, 71... [Pg.137]

Human immunodeficiency virus (HIV) type 1 gpl20 (V3 loop) protein Alfalfa mosaic virus in tobacco leaf Elicited specific virus-neutralizing antibodies in mice when delivered parenterally. 16... [Pg.146]

Transmissible gastroenteritis coronavirus N-terminal domain of the spike glycoprotein (S) Arabidopsis leaf gS elicited virus-neutralizing antibodies. -Immunogenic when administered parenterally. 114... [Pg.148]

Rabies virus protein Monoclonal antibody (mAb S057) Rabies virus neutralization N. tabacum cv Xanthi 35 S MSP +KDEL + 3 pg/g FLW (0.07% TSP) 33... [Pg.235]

Dietzschold, B., Gore, M., Marchandiar, D., et al. (1990) Structural and immunological characterization of a linear virus-neutralizing epitope of the rabies virus glycoprotein and its possible use in a synthetic vaccine. J. Virol. 64,... [Pg.271]

As previously described, 0.1 ml of each test and control parameter following the exposure period was added to a 0.9 ml aliquot of neutralizer followed immediately by 10-fold serial dilutions in test medium to stop the action of the test substance. To determine if the neutralizer chosen for the assay was effective in diminishing the virucidal activity of the test substance, low titer stock virus was added to each dilution of the test substance-neutralizer mixture. This mixture was assayed for the presence of virus (neutralization control above). [Pg.20]

Emini EA, Hughes JV, Perlow DS, Boger J (1985) Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide. J Virol 55 836-839... [Pg.136]

Several clinical studies have been conducted with oral influenza vaccines (Avtushenko et al. 1996 Lazzell et al. 1984). These include water in oil emulsion form of inactivated virus vaccine and an enteric-coated killed virus vaccine. Although these vaccines induced IgA responses, there were inadequate levels of virus-neutralizing IgG antibodies in the serum to fulfil regulatory requirements for vaccine immunogenicity. This warrants refinement and further development of these types of vaccines. [Pg.200]

Smith, T. J., Olson, N. H., Cheng, R. H., Chase, E. S., and Baker, T. S. (1993). Structure of a human rhinovirus-bivalently bound antibody complex Implications for virus neutralization and antibody flexibility. Proc. Natl. Acad. Sci. USA 90, 7015-7018. [Pg.445]

Vrati, S., Fernon, G. A., Dalgarno, L., and Weir, R. C. (1988). Location of a major antigenic site involved in Ross River virus neutralization. Virology 162, 346-353. [Pg.447]

The quality control of immunoglobulins includes potency tests and conventional tests for safety and sterility. The potency tests consist of toxin or virus neutralization tests that parallel those used for the potency assay of immune sera, except that for in-process control of some immunoglobulins wider use is made of in vitro assays. In addition to the safety and sterility tests, total protein is determined by nitrogen estimations, the protein composition by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and molecular size by high performance liquid chromatography. The presence of immunoglobulins derived from species other than humans is excluded by precipitin tests. Table 23.4... [Pg.414]

Castilla, J., Pintado, B., Sola, 1., Sanchez-Morgado, J.M., and Enjuanes, L. (1998). Engineering passive immunity in transgenic mice secreting virus-neutralizing antibodies in milk. Nat. Biotechnol. 16, 349-354. [Pg.194]

Harris SL. Frank I, Yee A, Cohen GH, Eisenberg RJ. Friedman HM (1990) Glycoprotein C of herpes simplex virus type 1 prevents complement-mediated cell lysis and virus neutralization. J Infect Dis 162 331-337... [Pg.199]

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See also in sourсe #XX -- [ Pg.11 , Pg.11 , Pg.857 , Pg.858 ]



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