Veterinary products

Veterinary medicine Veterinary medicines Veterinary products... 

Veterinary Products. Principal users of thiophene are the anthelmintics Pyrantel [15686-83-6] and Morantel [20574-50-9] (Pfizer) (59), based on 2-thiophenecarboxaldehyde and 3-methyl-2-thiophenecarboxaldehyde [5834-16-2], respectively. Tioconazole, one of a range of fungicidal products incorporating thiophene, has also found veterinary appHcations. 

J. Shepherd, paper presented to the Aquaculture Feed and Veterinary Products Worldwide Business Opportunities forFeed, Pharmaceutical, and Chemical Companies Conference, Stamford, Coim., June 6—8, 1990. 

Ampicillin—see Penicillin, D-n-aminobenzyl-Amprolium coccidiostat mode of action, 1, 212 as veterinary product, 2, 515 Amquinsin, 2, 517 Amylobarbitone metabolism, 1, 237 Anabasine, 2, 511 synthesis, 2, 385 Anabasine, N-methyl-N -oxide... 

Verdazyls — see 1,2,4,5-Tetrazinyl, 3-hydro-Verrucarin E synthesis, 1, 432 Vertical stack conductors, 1, 351 Veterinary products... 

The special topics discussed are (i) the biological aspects of heterocyclic compounds, i.e. their biosynthesis, toxicity, metabolism, role in biochemical pathways, and their uses as pharmaceuticals, agrochemicals and veterinary products (ii) the use of heterocyclic compounds in polymers, dyestuffs and pigments, photographic chemicals, semiconductors and additives of various kinds and (iii) the use of heterocyclic compounds as intermediates in the synthesis of non-heterocyclic compounds. 

G. Walker, Compendium of Data Sheets for Veterinary Products, Datapharm, Enfield, 1994. 

The previous chapters examined the process for the development and authorisation of a drug product containing a ne v active ingredient for human use. This represents the most arduous path to market for any medicinal product. This chapter proceeds to examine the process of bringing a veterinary medicinal product to market. While the process shares most of the principles that apply to human drugs, there are some additional features that are unique to veterinary products. These include methods of use and the requirement to evaluate vithdra val periods and maximum residue limits in food-producing species. 

The procedures and timelines for obtaining marketing authorisations for veterinary products are essentially the same as those for human medicines. Extensive guidance can be found in The Rules Governing Medicinal Products in the European Union, Volume 6 - Notice to Applicants, Veterinary Medicinal Products. The products that may follow centralised procedures and receive Community authorisations are shown in Eigure 7.5. All other products must obtain authorisations from national... 

Figure 7.5 Veterinary products that may be authorised via centralised procedures.

Figure 7.6 Outline of the dossier structure for a marketing application for a veterinary product.

They are administered orally or externally (via European Pharmacopoeial route in the case of veterinary products). 

Ranvet Veterinary Products, Salt Licks. Available online. URL http //www.ranvet.com.au/salt licks.htm. 

Development and Validation of a Proposed Regulatory Method, EMEA/CVMP/573100, Vol. 8, Veterinary Medicinal Products Establishment of Maximum Residue Limits (MRLs) for Residues of Veterinary Products in Foodstuffs of Animal Origin, Committee for Veterinary Medicinal Products, London (2001). Also available on the World Wide Web http //www.emea.eu.int/pdfs/vet/swp/057300en.pdf. 

Veterinary pharmaceuticals are of great importance in the United States and many other countries. (For more information on this topic, the reader is referred to the chapter on veterinary products.)... 

Other issues in veterinary bioequivalence which merit attention include policies to be followed when a product is to be used by more than one animal species. Is it sufficient to perform a bioequivalence study in only one species, or should studies be carried out in most or all the species for which the drug is recommended [46] There may be reason to believe that bioequivalence problems exist in some veterinary products [47,48]. 

Ben Venue Laboratories founded in 1938, specializes in the manufacturing of sterile products. Its activities and capabilities can be contracted on a project basis. Since its foundation, a long history of experiences on customized production of a wide variety of sterile products. Product portfolio includes lyophilized dosages, liquid dosages, small molecule compounds, biologicals, cytotoxics, diagnostics, veterinary products, potent compounds. 

A simple, specific, and accurate reversed-phase HPLC method for the assay of niclosamide and several anthelmintics in veterinary products was reported [73], The method afforded rapid and efficient separation, good resolution, and identification of the examined compounds, alone or combined. The method was used to quantify these drugs, alone or in combination, in tablet, powder, and liquid formulations. 

The technology of dry culture Colpoda steinii production is developed adjusted in the Ukraine (the Veterinary Products Company Renaissanc M ). 

Unique aspects of veterinary compounding compared to compounding for human patients include the potential impact on human health of compounded veterinary products in food animals, and variability in animal response and size. 

The CVMP operates in a similar fashion to the CPMP and is heavily involved in the review of centralized procedures for veterinary products. It has developed a broad range of new guidelines to assist applicants in topics related to research and development for which no guidance existed previously. 

The draft decision is then sent to the Standing Committee on Medicinal Products or the Standing Committee on Veterinary Products for their opinions. Should there be detailed opposition from a member state to the draft decision, the standing committee can refer it back to the CPMP if the opposition is scientific. If the matter is nonscientific, the council decision is made on the basis of a qualified majority, where each member state has a different number of votes depending on its size and importance and the majority of votes must be in favor. If within a further 30 days there is no opposition, the draft decision is forwarded to the Commission secretariat-general for adoption, enabling the Commissioner for enterprise and the information society to issue the final decision which is published in the Official Journal of the European Communities. 

Most organic farmers recycle their manures on the farm. Any other manure is likely to be polluted with residues of veterinary products used to treat the animals. If manure from an organic farm is not available, try to source it from pasture-raised herds or less intensive livestock units. You may find local stables that are eager to give away their manure, but do ask when their horses were last wormed. 

Chapter 5 of the document reviews the UFs used by UK Government departments, agencies, and their advisory committees in human health risk assessment. Default values for UFs are provided in Table 3 in the UK document with the factors separated into four classes (1) animal-to-human factor, (2) human variability factor, (3) quality or quantity of data factor, and (4) severity of effect factor. The following chemical sectors are addressed food additives and contaminants, pesticides and biocides, air pollutants, drinking water contaminants, soil contaminants, consumer products and cosmetics, veterinary products, human medicines, medical devices, and industrial chemicals. 

The relevant advisory committees with a remit for medicines for human use established under the Medicines Act 1968 were the Committee on Safety of Medicines (CSM), set up in June 1970 (SI 1970/1257) under the Chairmanship of Professor EF Scowen and the British Pharmacopoeia Commission (BPC), also set up in June 1970 (SI 1970/1256) under the Chairmanship of Dr F Hartley (later Sir Frank Hartley). The Veterinary Products Committee (VPC), chaired by Professor CSG Grunsell (with a remit for... 

Advising on the establishment and membership of committees established under section 4 of the Medicines Act 1968. For example, the British Pharmacopoeia Commission (BPC) and Veterinary Products Committee (VPC) would be retained. 

---