Small-molecule compounds

Although current matrix diffusional systems are most suitable for small-molecule compounds, it has been demonstrated (84) that soHd hydrophobic polymers allow dispersed powdered macromolecules of nearly any size, for example, ethylene—vinyl acetate copolymers containing dispersed polypeptides, to be released for periods exceeding 100 days. 

Over the last 10 years there has been a major initiative to bring HTS into the academic community. The NIH roadmap has a mission to build a better toolbox for medical research in the twenty-first century and to empower the research community to use small molecule compounds in their research, whether as tools to perturb genes and pathways, as imaging probes in basic or clinical applications, or as starting points to the development of new therapeutics for human disease. 

Ben Venue Laboratories founded in 1938, specializes in the manufacturing of sterile products. Its activities and capabilities can be contracted on a project basis. Since its foundation, a long history of experiences on customized production of a wide variety of sterile products. Product portfolio includes lyophilized dosages, liquid dosages, small molecule compounds, biologicals, cytotoxics, diagnostics, veterinary products, potent compounds. 

Allcock, H. R., Fitzpatrick, R. J. and Salvati, L. 1991. Sulfonation of (aryloxy) phosphazenes and (arlyamino)phosphazenes small-molecule compounds, polymers and surfaces. Chemistry of Materials 3 1120-1132. 

The other acetogenins, shown in Table II, are a varied assortment of small molecule compounds which as a group contain alkene, alcohol, and carbonyl (acid, ester, aldehyde, and ketone) functionality. They are fairly typical substances with common structural features. Again, those compounds possessing an odd number of carbon atoms are less common, and biogenetlcally may be derived from a propionate starter unit. 

Synthetic Lethal Screen of Small Molecule Compound Library... 

Kawasumi M, Nghiem P. (2007) Chemical genetics elucidating biological systems with small-molecule compounds. JInvest Dermatol 127, 1577-84. 

Employing the teabag approach for parallel synthesis, the reagent mixture method, and the libraries from libraries concept, a wide range of different small molecule compounds was successfully prepared in our laboratory during the past decade. Starting from amino acids and short... 

This simple sketch illustrates clearly that convergent multicomponent reactions performed with a limited set of reactive building blocks (reactophores) in a multigeneration format offer a tremendous potential to produce diverse small-molecule compound collections, depending on the reaction sequence used (the combinatorics of reactive building blocks ). The concept of combinatorics of reactive building blocks should ultimately lead to novel multicomponent reactions. In Section III we will focus on reactophores such as a-alkynyl ketones, which allow the construction of a wide variety of core structures. 

Fig. 10. Different techniques for competitive immuno-polymerase chain reaction of small-molecule compounds. (A) Using biotinylated haptens and a DNA-streptavidin nanocircle conjugate [105], hapten-DNA conjugates were synthesized and used for a competitive assay in a sample containing free hapten and capture antibody-coated surfaces [92]. (B) Hapten-coated microplates were simultaneously incubated with a sample containing free hapten and a hapten-specific antibody. Following competitive coupling, the immobilized antibody was subsequently detected by a species-specific antibody-DNA conjugate [93, 94].

Sensitivity of Yeast SKY48 and SKY54 to a Library of Small-Molecule Compounds... 

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