V-methyl-D-aspartate receptors

Bergeron, R, Meyer, TM, Coyle, IT and Greene, RW (1998) Modulation of V-methyl-D-aspartate receptor function by glycine transport. Proc. Natl. Acad. Sci. USA 95 15730-15734. 

V-methyl-D-aspartate receptors. Glutamate is the major excitatory neurotransmitter in the central nervous system (Ch. 15). Its receptors can be divided into three types AMPA/kainate, NMDA and metabotropic receptors. NMDA receptors are composed of two different types of subunit - NR1 and NR2. They play an important role in the induction of synaptic plasticity and excitotoxicity. 

Sacaan, A. I., andjohnson, K. M. (1990). Characterization of the stimulatory and inhibitory effects of polyamines on [3H] N-( -[thienyl] cyclohexyl) piperidine binding to the. V-methyl-D-aspartate receptor ionophore complex. Mol. Pharmacol. 37, 572—577. 

Rodriguez JJ, Garcia DR, Pickel VM. Subcellular distribution of 5-hydroxy-tryptamine2A and V-methyl-D-aspartate receptors within single neurons in rat motor and limbic striatum. J Comp Neurol 1999 413 219-231. 

Patel, M.N., Yim, G.K.W., Isom, G.E. (1992). Blockade of V-methyl-D-aspartate receptors prevents cyanide-induced neuronal injury in primary hippocampal culture. Toxicol. Appl. Pharmacol. 115 124-9. 

Huh KH, Wenthold RJ (1999) Turnover analysis of glutamate receptors identifies a rapidly degraded pool of the (V-methyl-D-aspartate receptor subunit, NRl, in eultured cerebellar granule cells. J Biol Chem 274 151-157. 

Watanabe M, Inoue Y, Sakimura K, Mishina M (1993) Distinct distributions of five (V-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain. J Comp Neurol iiS 377-390. 

Hirao K, Hata Y, Ide N, Takeuchi M, Irie M et al. (1998) A novel multiple PDZ domain-containing molecule interacting with )V-methyl-D-aspartate receptors and neuronal cell adhesion proteins. J Biol Chem 273 21105-21110. 

Yun H, Gonzalez-Zulueta M, Dawson V, Dawson T (1998) Nitric oxide mediates (V-methyl-D-aspartate receptor-induced activation of p21 ras. Proc Natl Acad Sci USA 95 5773-5778. 

Haley, J.E., Sullivan, A.F., Dickenson, A.H., 1990. Evidence for spinal V-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Res. 518, 218-226. 

Monahan, J.B., Hanadelmann, G.E., Hood, W.F., Cordi, A.A., 1989b. D-cycloserine, a positive modulator of the V-methyl-D-aspartate receptor, enhances performance of learning tasks in rats. Pharmacol. Biochem. Behav. 34, 647-653. 

Nowak, G., Trullas, R Layer, R.T., Skolnick, P., Paul, I.A., 1993. Adaptive changes in the /V-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarbo-xylic acid. J. Pharmacol. Exp. Then 265, 1380-1386. 

Toki S, Ando K, Kawamoto I, Sano H, Yoshida M, Matsuda Y. ES-242-2,-3, -4, -5, -6, -7, and -8, novel bioxanthracenes produced by Verticillium sp, which act on the /V-methyl-D-aspartate receptor. J Antibiot 45 1047-1054, 1992a. 

Sarcina lutea, 105 sarcoma, activate against, 72,180 selective V-methyl-D-aspartate receptor antagonists, 64, 177... 

Another signaling system based on LRPl heterodimerization appears to involve the V-methyl-D-aspartate receptor, which mediates calcium flux in cultured primary neurons. 

The molecular mechanisms underlying the complex CNS effects of ethanol are not fully understood. Specific receptors for ethanol have not been identified, but ethanol appears to facilitate the action of GABA at GABA receptors and inhibits the ability of glutamate to activate NMDA (/V-methyl-D-aspartate) receptors. It has been suggested that alcohol blackouts may result from the latter action. 

Tasker, R.A. et al.. Selective reduction in domoic acid toxicity in vivo by a novel non-V-methyl-D-aspartate receptor antagonist. Can J Physiol PharmacollA, 1047, 1996. 

Novelli, A., et al.. Glutamate becomes neurotoxic via the V-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res., 451, 205, 1988. 

Miao B, Yin XH, Pei DS, Zhang QG, Zhang GY (2(X)5) Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of INK 1/2 via V-methyl-D-aspartate receptor-mediated Aktl activation. J Biol Chem 280 21693-21699 Milldn M, AreniUas J (2006) Gene expression in cerebrd ischemia a new approach for neuroprotection. Cerebrovasc Dis 21(Suppl 2) 30-37... 

Bi H, Sze Cl (2002) V-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer s disease. J Neurol Sci 200 11-18... 

Brandt, C, Potschka, H, Loscher, W, Ebert, U (2003) V-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy. Neuroscience, 118 727-740. 

Nihei, M.K., Desmond, N.L., McGlothan, J.L., Krrhlmann, A.C., Guilarte, T.R., 2000. V-methyl-D-aspartate receptor subunit changes are associated with lead-induced deficits of long-term potentiation and spatial learning. Netrroscience 99, 233 —242. 

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