Uterine sarcoma

EPCl enhancer of polycomb 1. Subunit of the Tip60/NuA4 HAT complex. Physically links the Tip60-EPCl-ING3 trimer to the rest of the complex. Fused to PHFl/polycomb-like human protein in uterine sarcomas. 

No. of injections Sex Effective no. of mice Kidney tumours Colon tumours (%) Tumours of anal region (%) Tumours of the liver Uterine sarcomas (%) Lesions of ovary (%)... 

Two groups of 36 and 40 female C3HA mice (a strain resistant to 1,2-dimethylhydrazine induction of uterine sarcomas), 2-3 months of age, received 20 weekly sub-... 

Table 11. Incidence of uterine sarcomas in CBA mice given 1,2-dimethyl-...

Group Treatment Effective no. of mice Mice with uterine sarcomas p value compared with group 1 Time (weeks) of observation of tlie first uterine sarcoma... 

Uterine fibroids and endometrial polyps (sometimes with bleeding) have been reported in menopausal women who had taken tamoxifen for periods of months or years (SEDA-16, 466) (92,93). In view of this, the question of whether tamoxifen increases the risk of endometrial cancer has been widely discussed. The authors of a 1993 review of the outcome of six major trials tended strongly to the conclusion that tamoxifen can cause both endometrial hyperplasia and endometrial cancer proportional to the total dose (94) the figures pointed to an overall incidence of endometrial cancer of 0.5 % in tamoxifen users and 0.1% in controls. Another major review up to 1992 concluded that in the world literature there were 70 cases of uterine malignancies with tamoxifen, including 61 cases of adenocarcinoma of the endometrium and four cases of uterine sarcoma (95). 

Various types of adherent cells were grown on a coverslip, which was then laid on top of the LAPS chip. Measurements were made for acidification of (1) normal human epidermal keratinocytes stimulated by epidermal growth factor (EGP) or organic chemicals, and of (2) human uterine sarcoma cells as a response to doxorubicin and vincristine (chemotherapeutic drugs). In addition, the inhibition (by ribavirin) of the viral infection of murine fibroblastic L cells by vesicular stomatitis virus (VSV) was investigated by following the acidification rate. A limitation of these studies is the requirement for a low-buffered medium (low bicarbonate content) to achieve maximum sensitivity [847]. 

Lissoni A, Cormio G, Colombo N, Gabriele A, Landoni F, Zanetta G, Mangioni C. High-dose epirubicin in patients with advanced or recurrent uterine sarcoma. Int J Gynaecol Cancer 1997 7 241. ... 

Tanioxircn hits seen extensive use in treating primary breast cancers that arc ER dependent, For premenopausal women with metastatic disease, tamoxifen is an alternative and adjuvant with oophorectomy, ovarian irradiation, and mastectomy. Tamoxifen u.se. however, is not problem free. Tamoxifen increases the incidence of endometrial polyps. hyperplasia, and carcinoma and uterine sarcomas. The risk of endometrial cancer resulting from tamoxifen is. however. much lower than the "modest but highly significant reductions in morbidity and mortality of breast cancer." Becau.se of the increased risk of endometrial cancer with tamoxifen therapy, tamoxifen. should be u.sed to prevent breast cancer only in women at high ri.sk. Women without a family history of breast cancer or other risks should not use tamoxifen in this manner. 

Uterine sarcoma MES-SA is derived from human uterus sarcoma. MES-SA/DX-5 is a multiple drug resistant cell line established from MES-SA cells. These two cell lines are generally used together to study multi-drug resistance and to test modulators to enhance drug delivery across the cell membrane. 

Sutton GP, Stehman FB, Michael H, et al. Estrogen and progesterone receptors in uterine sarcomas. Obstet Gynecol. 1986 68 709-714. 

Nordal RR, Kristensen GB, Stenwig AE, et al. Immunohistochemical analysis of p53 protein in uterine sarcomas. Gynecol Oncol. 1998 70 45-48. 

Al-Badr A, Faught W (2001) Uterine artery embolization in an undiagnosed uterine sarcoma. Obstet Gynecol 97 836-837... 

Hata K, Hata T et al (1997) Uterine sarcoma can it be differentiated from uterine leiomyoma with Doppler ultra-... 

Parker WH, Fu YS et al (1994) Uterine sarcoma in patients operated on for presumed leiomyoma and rapidly growing leiomyoma. Obstet Gynecol 83 414-418... 

Kawamura N, Ichimura T, Ito F, Shibata S, Takahashi K, Tsujimura A, Ishiko 0, Haba T, Wakasa K, Ogita S (2002) Transcervical needle biopsy for the differential diagnosis between uterine sarcoma and leiomyoma. Cancer 94 1713-1720... 

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