Used in the Treatment of Fungal Infections

McCormack PL, Perry CM. Caspofungin a review of its use in the treatment of fungal infections. Drugs 2005 65 2049-2068. 

Nonprescription topical antifungal agent not effective in the treatment of deeper fungal infections of the skin, nor is it reliable in the treatment of fungal infections involving the scalp or nail beds Candida is resistant useful for patients desiring self-medication of mild tinea infections patients must be advised of limitations... 

Dichlorophen is an antihelminthic drug that was used in the treatment of tapeworm infections but has been superseded by praziquantel and niclosamide. It also has antifungal and antibacterial activity and has been used topically in the treatment of fungal infections and as a germicide in soaps and cosmetics (1). 

The inhalation of thymol, in combination with other volatile substances, is used to alleviate the symptoms of colds, coughs, and associated respiratory disorders. Externally, thymol has been used in dusting powders for the treatment of fungal skin infections. Thymol was formerly used in the treatment of hookworm infections but has now been superseded by less toxic substances. 

Clotrimazole is an imidazole antifungal agent indicated for the treatment of fungal infections caused by Candida albicans. The administration of clotrimazole would be of no use in the treatment of infections caused by Chlamydia trachomatis, Neisseria gonorrhoea, Staphylcoccus aureus and Streptococcus pneumoniae. 

Antifungal agents are used in the treatment of topical and systemic fungal infection. They can be classified as systemic or topical antifungal agents and some are used both systemically as well as topically in the form of powder, ointment and vaginal tablets etc. They are classified as in table 9.7.1. 

Selenium sulfide is used as shampoo and used in the treatment of scalp fungal infection. 

Griseofulvin (60) is an antifungal agent that becomes concentrated in the skin after oral administration, and it is useful in the treatment of cutaneous fungal infections. Bleomycin and similar antibiotics are discussed as chelating agents (p. 159). 

Dextromethorphan is known to interact with quini-dine and terbinafine. In both cases, there is a reduction in the metabolism of dextromethorphan by the liver. Terbinafine is a drug used to treat fungal infections. Quinidine is used for the treatment of malarial infections and heart rhythm problems. There has been a case report of a drug interaction between the use of fluoxetine (Prozac) and dextromethorphan. Fluoxetine is an antidepressant in the class of drugs called serotonin reuptake inhibitors. 

Amphotericin B (AmB) is a polyene macrolide used in the treatment of systemic fungal infections. The clinical use of amphotericin, however, is limited by its dose-dependent nephrotoxicity. A number of studies have shown that AmB is... 

Amphotericin B is an extremely potent anti-fungal agent used in the treatment of systemic fungal infections. However, delivery of amphotericin B is very difficult due to its insolubility in the water as well as commonly used oils. Furthermore, it shows several adverse effects such as nephrotoxicity. Brime et al. [109] successfully entrapped amphotericin B in the lecithin-based microemulsions and evaluated their acute toxicity in the mice in comparison to the marketed formulation. Acute toxicity studies indicated that... 

Topical administration to the epidermis of the skin is generally used for drugs intended to have a local effect. This route is of particular relevance to podiatrists and can be used to treat a local infection or other conditions. For example, the use of amorolfine cream in the treatment of fungal skin infections. 

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