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Antifungal agents topical

Clotrimazole, which is used only topically, is available as a 1% cream, lotion, or solution (Lotrimin and Mycelex), as a 1% vaginal cream, as 100- or 500-mg vaginal tablets (Gyne-Lotrimin, Mycelex-G), and as 10-mg troches (Mycelex). [Pg.439]

Mechanism of Action. Like the systemic azoles, clotrimazole and other topical antifungal azoles work by inhibiting the synthesis of key components of the fungal cell membrane that is, these drugs impair production of membrane sterols, triglycerides, and phospholipids.9 Loss of these components results in the membrane s inability to maintain intracellular homeostasis, leading to death of the fungus. [Pg.550]

Adverse Effects. There are relatively few side effects when these drugs are applied locally. Gastrointestinal distress (cramps, diarrhea, vomiting) can occur [Pg.550]

Clinical Use. Other topical antifungals include nystatin (Mycostatin, Nilstat, others), naftifine (Naftin), butenafine (Mentax), and tolnaftate (Aftate, Tinactin, other names) (see Table 35-2). [Pg.551]

Naftifine, tolnaftate, and butenafine are used primarily to treat local and superficial cases of tinea infection. These agents are found in several over-the-counter products that are administered topically to treat tinea infections such as tinea pedis and tinea cruris. [Pg.551]

Adverse Effects. Nystatin is generally well tolerated when applied locally. Systemic absorption through mucous membranes may cause some gastrointestinal disturbances (nausea, vomiting, diarrhea), but these side effects are generally mild and transient. Topical use of butenafine, naftifine, and tolnaftate is likewise safe, although local burning and irritation of the skin may occur in some individuals. [Pg.551]


Bifonazole (109) is claimed to be remarkably non-toxic and is marketed as a topical antifungal agent overseas. It can be conveniently synthesized in the by now familiar way by reduction of p-phenylbenzophenone (108) with borohydride, conversion to the chloride with thionyl chloride, and then imidazole displacement to bifonazole (109) [39]. [Pg.93]

How to administer topical antifungal agents, including cleaning the oral cavity prior to administration, administering after meals, how to dissolve troches, and how to swish suspensions... [Pg.1206]

The use of topical antifungal agents (imidazole antifungals and terbinafine) is the first-line of treatment in athlete s foot. Patients should be advised to be persistent in treatment and that application of the product should be continued for about 10 days after all traces have disappeared. This will ensure eradication. Patient should be educated on non-pharmacotherapeutic measures and adjunctive therapy that contribute towards the management of the condition. The area should be washed regularly and dried thoroughly as... [Pg.129]

The topical antifungal agent ciclopirox (32) was formed from 2-pyrone 31 by an azaphilone reaction... [Pg.788]

Ketoconazole remains useful in the treatment of cutaneous and mucous membrane dermatophyte and yeast infections, but it has been replaced by the newer triazoles in the treatment of most serious Candida infections and disseminated mycoses. Ketoconazole is usually effective in the treatment of thrush, but fluconazole is superior to ketoconazole for refractory thrush. Widespread dermatophyte infections on skin surfaces can be treated easily with oral ketoconazole when the use of topical antifungal agents would be impractical. Treatment of vulvovaginal candidiasis with topical imidazoles is less expensive. [Pg.600]

Other older, less effective topical antifungal agents still available include undecyleitic acid Desenex, others). Used in the treatment of topical dermatophytes, undecyleitic acid is fungistatic, requires prolonged administration, and is associated with a high relapse rate. Desenex, containing 5% undecyleitic acid and 20% zinc undecylenate, is effective in the prevention of recurrent tinea pedis. [Pg.602]

Nonprescription topical antifungal agent not effective in the treatment of deeper fungal infections of the skin, nor is it reliable in the treatment of fungal infections involving the scalp or nail beds Candida is resistant useful for patients desiring self-medication of mild tinea infections patients must be advised of limitations... [Pg.1242]

Zinc is used for a variety of indications. Zinc acetate (8.102) or, rarely, zinc sulfate (8.103) have been used orally to treat Wilson s disease, a recessively inherited disorder of copper metabolism, characterized by brain and liver dysfunction arising from excessive deposits of copper. Zinc pyrithione (8.104) is used in shampoos to treat seborrhea. Zinc propionate (8.105) and zinc caprylate (8.106) have been used as topical antifungal agents. [Pg.535]

Antifungal agents are used in the treatment of topical and systemic fungal infection. They can be classified as systemic or topical antifungal agents and some are used both systemically as well as topically in the form of powder, ointment and vaginal tablets etc. They are classified as in table 9.7.1. [Pg.343]

Agents used to treat common fungal infections are listed in Tables 35-1 and 35-2. As indicated in Table 35-1, certain drugs can be administered systemic ally to treat infections in various tissues. Other agents are more toxic their use is limited to local or topical application for fungal infections in the skin and mucous membranes (Table 35-2). The use of systemic and topical antifungal agents is addressed in more detail below. [Pg.546]

Shear NH, Villars VV, Marsolais C. Terbinafine an oral and topical antifungal agent. Clin Dermatol 1991 9(4) 487-95. [Pg.3320]

Lufenuron is a benzoylurea compound with chitin synthetase inhibitory activity that is used principally as a systemic insecticide. Given orally to horses, at a dose rate of 5 mg/kg once daily, lufenuron may be beneficial when used in combination with topical antifungal agents. The potential toxicity of this compound in the horse has not been investigated. [Pg.232]

Ramadan W, Mourad B, Ibrahim S, Sonbol F. Oil of bitter orange new topical antifungal agent. Int J Dermatol 1996 35 448 149. [Pg.241]

The fungicide (prochloraz), the topical antifungal agent (miconazole) and 7. 8-benzoflavone (a strong inhibitor of cytochrome P-450) limited the conversion of benzo[a]pyrene to a mutagen in S. typhimurium. The order of inhibitory action was 7.8-benzoflavone > prochloraz > miconazole (Antignac et al. 1990). [Pg.193]

Clean the oral cavity prior to administering the topical antifungal agent. Daily fluoride rinses may help reduce the risk of caries when using an agent containing sucrose or dextrose. [Pg.2156]

Use the topical antifungal agent after meals as saliva flow and mouth movements can reduce the contact time. [Pg.2156]

Exelderm ( )-1H-lmidazole, 1-(2- ((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)-ethyl)- Sulconazol Sulconazole Sulconazolum. Topical antifungal agent, C.M. ind. ICI Chem. Polymers Ltd. Syntax Labs. Inc. [Pg.592]


See other pages where Antifungal agents topical is mentioned: [Pg.499]    [Pg.136]    [Pg.282]    [Pg.379]    [Pg.423]    [Pg.480]    [Pg.602]    [Pg.296]    [Pg.427]    [Pg.550]    [Pg.560]    [Pg.436]    [Pg.439]    [Pg.1445]    [Pg.294]    [Pg.303]    [Pg.366]    [Pg.536]    [Pg.171]    [Pg.2337]    [Pg.232]    [Pg.545]    [Pg.2213]    [Pg.4]    [Pg.219]    [Pg.628]    [Pg.808]    [Pg.136]   
See also in sourсe #XX -- [ Pg.479 ]




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