Uncontrollable use

The uncontrolled use of parallel or combinatorial synthetic chemistry in hit and lead optimization (and in compound collection enhancement)... 

This is a warning against the uncontrolled use of apparently innocuous substances. The absence of adverse effects in healthy people taking melatonin for various reasons does not mean complete safety, particularly in people who are unwell. 

Chlorinated aromatic compounds are hazardous compounds that result from various industrial and agricultural activities. Water disinfection, waste incineration, and uncontrolled use of biocides are the major sources of chlorinated aromatics in the environment. Chlorinated compounds are also formed as subproducts of the biochemical reactions of herbicides containing chlorophe-noxy compounds. Treatment of chlorinated compounds has been studied using biological treatment, adsorption, air stripping, and incineration. Biodegradation of chlorinated compounds is a slow process that is ineffective for extremely low concentrations. Air stripping and adsorption simply trans-... 

Chlorophenols (CPs) constitute a group of organic substances that are introduced into the environment as a result of several human activities (e.g., water disinfection, waste incineration, uncontrolled use of pesticides and herbicides). The rate constants for the global processes and the efficiency of the various AOPs tested are compared in the following sections. 

Such factors make India an area of great concern while evaluating the global status, transport and distribution of persistent toxic substances, because of its increasing and uncontrolled use of chemicals, their distinctive climatic conditions, excessive population, multitude of diseases, intensive agriculture, increased industrialization, etc. (Allsopp and Johnston, 2000). 

Autotrophic vegetation as a whole has rendered possible the development of animals on earth, of consumers and predators at the higher levels in the food chains of ecosystems. More than 100,000 species of animals, most of them insects, depend on the producers life. Mankind cannot survive without green plants and their capability of building up carbohydrates from just water and carbon dioxide in the chloroplasts of leaves by the use of solar energy. Agriculture and horticulture have made use of this capacity since prehistoric ages and forestry has developed from the uncontrolled use of firewood and timber for houses, ships> tools, and furniture to a planned production of renewable raw materials. 

One of the most striking features in microbiology is the rapid emergence and worldwide spread of penicillin-resistant S. pneumoniae (pneumococci), mainly due to the uncontrolled use of peniciUin in certain countries... 

The continuous spread of resistance among clinical isolates, especially of multiresistant microorganisms represents a unique challenge in the treatment of infectious diseases. The detection of asymptomatic carriers of pneumococci, especially young children in day care centers, makes early detection even more difficult (310). Uncontrolled use of antibiotics in agriculture selects multiresistant fecal flora in animals, and meat can be contaminated by imperfect processing. 

Uncontrollable Use A person addicted to medication has an uncontrollable urge to self-medicate. 

The thalamus functions as a relay station for sensory and motor information going to and from the cortex to other areas of the brain and body. The outermost layer of the brain is the cortex, which is made up of layers of nerve cells or neurons, and has a highly folded organization that increases its surface area and the number of neiuons that it contains (11, 17). The cortex is involved in many aspects of psychotropic plant use, from the primary effects of psychoactive drugs on sensations and perceptions, to the complex behaviours and thoughts involved in drug craving and uncontrolled use (17). 

The Bureau of Entomology argued for continued controls use should be allowed only when government scientists had determined the spraying was necessary, would not leave harmful residues, and would not cause ecological upset. The manufacturers were divided. One asked the War Production Board to maintain rigid supervision uncontrolled use would be dangerous because we have not yet established the safety controls. Another view prevailed, however. As soon as there was a considerable surplus, companies would be free to sell to anyone in any quantity.25... 

Nephrotoxins are usually easy to identify when deriving from well known therapeutic agents. However, their identification requires a detective work when causes involve the uncontrolled use of herbs ingredients in home remedies or folk medicine. The difficulty is compounded by the fact that patients do not mention their regular use of herbal powders or infusions because they consider these natural products to be harmless [1]. 

Kelp and kombu contain the element iodine (0.14-0.44% dry weight) (Dawczynski et al. 2007 Teas et al. 2004). Iodine idiosyncrasy, hyperthyroidism, and thyroid toxicity have been indicated as possible side effects after long-term, uncontrolled use of iodine-containing products, such as kelp, bull kelp, or kombu (Wichtl 2004). Excessive consumption of iodine can lead to goiter (swelling of the thyroid gland) (Baker 2004 Pennington 1990). 

Opium the congealed or dried latex of Papaver somniferum. The chief active constituents of O. are the Opium alkaloids (see). O. is smoked, or preparations from it may be ingested or injected. Uncontrolled use leads to addiction and deterioration of personality. The action of O. is essentially similar to, but weaker than that of its constituent Morphine (see). 

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