Tumours tumour imaging

N-donor groups in the form of e-amino groups of lysine as nonspecific binding sites for technetium may play an undesired role in Tc-labelling of monoclonal antibodies for tumour imaging [51]. Nonspecifically bound Tc has a poor in vivo stability and appears to increase the undesired liver uptake and reduces tumour uptake. The metal oxidation state and coordination is not yet known. 

Gallium is non-essential, but on account of the similarity between Ga3+ and Fe3+ it binds to iron transport and storage proteins such as transferrin and ferritin. The radioactive isotope of gallium, 67Ga, concentrates to a large extent in many tumours and at sites of inflammation and infection, and since many tumours overexpress the transferrin receptor it can be used for tumour imaging. 

Zhang G, Palmer GM, Dewhirst MW, Fraser CL (2009) A dual-emissive-materials design concept enables tumour hypoxia imaging. Nat Mater 8 747-751... 

Although contrast enhancement with the agents covered in this chapter mainly rehes upon a more distinct perfusion of tumours compared to normal tissue, as is achieved with ICG, and does not employ target-specific moieties, the value of contrast-enhanced tumour imaging was successfully demonstrated. These agents represent the classical format of a contrast agent. 

Also the preparation of the tumour imaging agents 5-[ F]fluorocytosine [108] (Scheme 28) and cytosine derivative [ F]capecitabine [109] can be considered as a direct /7eferoaromatic electrophilic dehydrogenation. 

Perkins, A.C., and Missailidis, S. (2007) Radiolabelled aptamers for tumour imaging and therapy. The Quarterly Journal of Nuclear Medicine and Molecular Imaging 51 292-296. 

Ogihara-Umeda, I., Sasaki,T.,Kojima,S., and Nishigori, H. (1996), Optimal radiolabelled liposomes for tumour imaging, J. Nucl. Med., 37,326-332. 

Laverman, R, Boerman, O. C., Corstens, F. H. M. and Oyen, W. J. G. (2002) Fluorinated amino acids for tumour imaging with positron emission tomography. European Journal of Nuclear Medicine and Molecular Imaging, 29(5), 681-690. 

Clinical studies Tumour imaging Two participants demonstrated the... 

Goodwin, D., Meares, C Diamanti, C McCall, M Lai, X., Torti, F McTigue, M., and Martin, B. (1984) Use of specific antibody for rapid clearance of circulating blood background from radiolabelled tumour imaging proteins. Eur. J. Nucl. Med. 9, 209-215. 

Kennel, S. J., Foote, F. J., Fanford, P. K., Johnson, M., Mitchell, T., and Braslawsky, G. R. (1983) Direct binding of radio-iodinated monoclonal antibody to tumour cells significance of antibody purity and affinity for drug targeting or tumour imaging. Hybridoma 2, 297-310. 

Atkinson, S.J. et al., Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption ionization mass spectrometry, Rapid Commun. Mass Spectrom., 21, 1271, 2007. 

Simple reactions are best, but the complex conversion carried out using sequential enzymic transformations for the synthesis of labelled 5-hydroxy tryptophan, for use in neuroendocrine tumour imaging, is notable. ... 

Goldenberg, D.M., Deland, F.H., History and status of tumour imaging with radiolabeled monoclonal antibodies. J. Nucl. Med. 1985, 25, 538-549. 

Nock B, Nikolopoulou A, Chiotellis E et al (2003) " Tc-Demobesin 1, a novel potent bombesin analogue for GRP receptor-targeted tumour imaging. Eur J Nucl Med Mol Imaging 30 247-258 Okarvi SM (2004) Peptide-based radiopharmaceuticals future tools for diagnostic imaging of cancers and other diseases. Med Res Rev 24 357-397... 

Colon carcinoma and diverticulitis both affect mainly the distal colon of aging patients in Western countries both can present with perforation,obstruc-tion or fistula formation. Differentiation obviously has critical prognostic importance. Chronic symptoms of weight loss or bleeding should raise suspi-don for carcinoma. In carcinomas usually a circumscribed thickening of the colon is seen. In some cases it is not possible to differentiate diverticulitis from a perforated tumour by imaging methods. 

Indium. In is a relevant radionuclide for SPECT imaging, with a half-life of 2.8 days and photon energies of 171 and 245 keV. Particular applications to dates are in tumour-targeted imaging. 

A review on the value of magnetic resonance spectroscopy in tumour imaging and diagnosis has been produced. ... 

Van de Wiele C, Dumont F, Van Belle S, Siegers G, Peers SH, Dierckx RA. Is there a role for agonist gastrin-releasing peptide receptor radioUgands in tumour imaging Nucl Med Commun 2001 22 5-15. 

Becherer A, Karanikas G, Szabo M, Zettinig G, Asenbaum S, Marosi C, Henk C, Wunderbaldinger P, Czech T, Wadsak W, Kletter K. Brain tumour imaging with PET a comparison between [18F]fluorodopa and [llC]methionine. Eur J Nucl Med Mol Imaging 2003 30 1561-1567. 

In developing new techniques of tumour imaging with radioisotopes, one goal is to label single-chain antibody fragments which may efficiently target tumours. The complex P" Tc(OH2)3(CO)3r ... 

---