Gastrin-releasing peptide receptor

Benya, R. V., Fathi, Z., Battey, J. F., and Jensen, R. T, (1993) Serines and threonines in the gastrin-releasing peptide receptor carboxyl terminus mediate internalization. J. Biol. Chem. 268,20285-20290. 

Ally RA, Ives KL, Traube E, Eltounsi I, Chen PW, Cahill PJ, Battey JF, Hellmich MR, Kroog GS (2003) Agonist- and protein kinase C-induced phosphorylation have similar functional consequences for gastrin-releasing peptide receptor signaling via Gq. Mol Pharmacol 64(4) 890-904... 

Mil. Markwalder, R., and Reubi, I. C., Gastrin-releasing peptide receptors in the human prostate Relation to neoplastic transformation. Cancer Res. 59, 1152—1159 (1999). 

Cyclen peptide derivatives, (I), prepared by Hoffman (2) were capable of binding to the gastrin releasing peptide receptor. When radiolabeled with either "Tc or 188Re, they were used as therapeutic or diagnostic agents. 

Panigone S, Nunn AD. Lutetium-177-labeled gastrin releasing peptide receptor binding analogs a novel approach to radionuclide therapy. Quart. J. Nucl. Med. Mol. Imaging 2006 50 310-321. 

LA BELLA, R., et al., In vitro and in vivo evaluation of a Tc(I)-labelled bombesin analogue for imaging of gastrin releasing peptide receptor-positve tumours, Nucl. Med. Biol. 29 (2002) 553-560. 

Mokotoff M, Ren K, Wong LK, et al. Synthesis and biological evaluation of novel potent antagonists of the bombesin/gastrin releasing peptide receptor. J Med Chem 1992,35 4696-4703. 

Hoffman TJ, Gali H, Smith CJ, Sieckman GL, Hayes DL, Owen NK, Volkert WA. Novel series of In-labeled bombesin analogs as potential radiopharmaceuticals for specific targeting of gastrin-releasing peptide receptors expressed on human prostate cancer cells. J Nucl Med 2003 44 823-831. 

Van de Wiele C, Dumont F, Van Belle S, Siegers G, Peers SH, Dierckx RA. Is there a role for agonist gastrin-releasing peptide receptor radioUgands in tumour imaging Nucl Med Commun 2001 22 5-15. 

Gastrin 17 Gastrin releasing peptide receptor, GCPR Leads to pepsin secretion... 

L. Prasanphanich, A. Sieckman, G. Hoffman, T. J. Volkert, W. A. Smith, C. J. In vitro and in vivo evaluation of Alexa Eluor 680-bombesin[7,14]NH2 peptide conjugate, a high-affinity fluorescent probe with high selectivity for the gastrin-releasing peptide receptor. Mol. Imaging 2007,6,171-180. 

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