Tumor necrosis factor superfamily

The neurotrophin receptor p75 was first identified as a nerve growth factor (NGF)-binding protein and was subsequently shown to interact with each of the other neurotrophic factors, BDNF, neurotrophin-3, and neurotrophin-4/-5. It also modulates the activity of several members of the tropomyosin-related receptor tyrosine kinase family (Trk) (reviewed in Chao, 2003). p75, a member of the tumor necrosis factor superfamily, is a type I transmembrane protein with four cysteine-rich domains in its extracellular region and a Death domain in its cytoplasmic protein (Fig. 11). 

Remacle-Bonnet, M., Garrouste, F., et al. (2005). Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. Am J Pathol 167(3) 761-73. 

Ashkenazi A (2002) Targeting death and decoy receptors of the tumor necrosis factor superfamily. Nat Rev Cancer 2 420-430... 

Tumor necrosis factor receptor associated factors are a group of at least 6 proteins (TRAF 1-6), which are major signal transducers for the TNF receptor superfamily and the the interlukin-1 receptor/toll-like receptor (IL-1R/ TLR) superfamily. TRAF proteins are characterized by the presence of the TRAF domain at the the C-terminus,... 

Tumor Necrosis Factor a TNF Receptor Superfamily Cytokines Inflammation... 

Both tumor necrosis factor receptors (TNFR) are type I transmembrane proteins, also belonging to a large family of proteins, the TNFR superfamily... 

Tumor necrosis factor ligand superfamily member 2... 

Kwon BS, Wang S, Udagawa N, Haridas V, Lee ZH, Kim KK, Oh KO, Greene J, Li Y, Su J, Gentz R, Aggarwal BB, Ni J (1998) TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. FASEB J 12 845-854... 

L5. Leithauser, F., Dhein, J., Mechtersheimer, G., Koretz, K., Bruderlein, S., Henne, C., Schmidt, A., Debatin, K. M., Krammer, R H., and Moller, R, Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab. Invest. 69, 415-429 (1993). 

The 110 bp region of the TNFRSF21 gene (tumor necrosis factor receptor superfamily, member 21 precursor), inserted in the plasmid... 

The extrinsic pathway consists of a series of events initially induced by death receptors located on the cell surface. It is initiated by interaction of extracellular death ligands with their respective receptors, located on the surface of the plasma membrane. The death ligands are members of the tumor necrosis factor (TNF)/nerve growth factor (NGF) superfamily. TNF-R1, Fas (Apo-l/CD95), TRAIL-R1, TRAIL-R2, and NGF-R are examples of death receptors. They are transmembrane proteins consisting of an external domain, where the ligand associates, and a cytoplasmic domain, which contains the DD (death domain). 

Diverse stimuli have been shown to trigger apoptosis. In general, at least three types of pro-apoptotic stimuli are identified. First, many receptors have been shown to initiate apoptosis. The most important of these belong to the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily and include CD95, the Trail-receptor DR4, and the TNF receptor (TNF-R) (Walczak and Krammer, 2000 Holtzman et al., 2000). These receptors are constitutively present or up-regulated on the cell surface... 

ASSEMBLY OF POST-RECEPTOR SIGNALING COMPLEXES FOR THE TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY... 

The tumor necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins that are structurally related in their extracellular domains and specifically activated by the corresponding superfamily of TNF-like ligands (Locksley et al, 2001). Members of this receptor superfamily are widely distributed and play important roles in many crucial biological processes such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases (Ashkenazi and Dixit, 1998 Leonen, 1998 Newton and Decicco, 1999). 

Akiba, H., Nakano, H., Nishinaka, S., Shindo, M., Kobata, T., Atsuta, M., Morimoto, C., Ware, C. F., Malinin, N. L., Wallach, D. et al (1998). CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. / Biol. Chem. 273, 13353-13358. 

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