Tumor necrosis factor receptor family

Wong BR, Rho J, Arron J, Robinson E, Orlinick J, Chao M, Kalachikov S, Cayani E, Bartlett FS, III, Frankel WN, Lee SY, Choi Y (1997) TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem 272 25190-25194... 

Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ (1999) Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 96 3540-3545... 

M13. Mosialos, G., Birkenbach, M., YalamanchiU, R., VanArsdale, T., Ware, C., and Kieff, E., The Epstein—Barr virus transforming protein LMP1 engages signah ng proteins for the tumor necrosis factor receptor family. Cell 80,389—399 (1995). 

Gravestein, L. A., and Borst, J. (1998). Tumor necrosis factor receptor family members in the immune system. Sem. Immunol. 10, 423-434. 

Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ (1997) ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. J Biol Chem 272 13471-13474. 

Panus JF, Smith CA, Ray CA et al. Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family a soluble, secreted CD30 homologue. Proc Natl Acad Sci USA 2002 99 12) 8348-8353. 

The Fas ligand or FasL is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. The binding of Fas ligand with its receptor induces apoptosis. 

Both tumor necrosis factor receptors (TNFR) are type I transmembrane proteins, also belonging to a large family of proteins, the TNFR superfamily... 

Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20 345-357... 

Zapata, J. M., et al., A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. / Biol Chem, 2001, 276(26), 24242-52. 

Arch, R. H., R. W. Gedrich, and C. B. Thompson, Tumor necrosis factor receptor-associated factors (TRAFs) — a family of adapter proteins that regulates life and death. Genes Dev, 1998, 12(18), 2821-30. 

It is well established that caspases participate in the final stages of apoptosis (Fig. 32-4), but what initiates the process There appear to be many ways in which apoptosis can be triggered. If every cell has a proper location in the body, which is determined by signals from adjacent cells, what will happen if the cell becomes detached There is evidence that such detachment with the loss of survival signals causes apoptosis.53a 152b Cell damage is also a major trigger. In other cases the cell is "instructed" to die. An example is the death of unneeded lymphocytes, one of many cellular processes induced by cytokines of the tumor necrosis factor (TNF) family. To allow for this process cells have surface receptors of the TNF... 

The stress or growth pathways modulated by vanadium involve specialized effectors and often can be activated by excess ROS. Cytokines, small proteins that effect communication between cells or cell behavior, can be involved in the cellular stress response. Tumor necrosis factor a (TNFa) is a cytokine stress signal that binds to a membrane receptor (tumor necrosis factor receptor, or TNFR). This interaction stimulates kinase activity that leads to cell injury and inflammation and also to the activation of caspases, a family of cysteine-dependent aspartate-directed proteases that are involved in apoptosis. The mitogen-activated protein (MAP) kinase cascade regulates both mitosis and apoptosis signaling pathways. 

Gedrich, R. W., Gilfillan, M. C., Duckett, C. S., Van Dongen, J. L., and Thompson, C. B. (1996). CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins./. Biol. Chem. 271, 12852-12858. 

Ishida, T. K., Tojo, T., Aoki, T., Kobayashi, N., Ohishi, T., Watanabe, T., Yamamoto, T., and Inoue, J. (1996b). TRAE5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc. Natl. Acad. Sci. USA 93, 9437-9442. 

Regnier, C. H., Tomasetto, C., Moog-Lutz, C., Chenard, M. P., Wendling, C., Basset, P., and Rio, M. C. (1995). Presence of a new conserved domain in CARTl, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma./. Biol. Chem. 270, 25715—25721. 

Rothe, M., Wong, S. C., Henzel, W. J., and Goeddel, D. V. (1994). A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78, 681-692. 

Selection of newdy formed B cells to transitional, follicular and marginal-zone (MZ) B cells depends on integrated signals from several classes of surface receptors such as, the BCR and co-signals, the tumor-necrosis factor receptor (TNER) family, and the G-protein-coupled receptors (GPCRs). 

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