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Tumor against Ehrlich ascites

Weakly antibiotic effective against Ehrlich ascites and SI80 tumors in mice only at dose close to LD50 360... [Pg.147]

In the assay of cytotoxicity of qinghaosu and related compounds against Ehrlich ascites tumor cells, qinghaosu, artemether, arteether, and artesunate exhibited cytotoxicity (IC50 12.2 29.8 pM), artemisitene 51 was more active (IC50 6.8 pM), and the dimer of dihydroartemisinin was the most potent (IC50 1.4 pM). ... [Pg.223]

More recently, we have evaluated a number of maleic anhydride copolymers (Table IV) and 2,3-dicarboxynorbom-5-ene copolymers (Table V) against Ehrlich ascites tumor ( 33). In both of these systems, very little or no activity was observed for the 10,000-30,000 molecular weight fraction compared to pyran. However, the lower molecular weight fractions (1,000-10,000) all produced good activity and in many cases were better than pyran. [Pg.208]

Table IV. Effect of Maleic Anhydride Copolymers Against Ehrlich Ascites Tumor Cells ... Table IV. Effect of Maleic Anhydride Copolymers Against Ehrlich Ascites Tumor Cells ...
C20H26O6. Mr 362.42, mp. 297-299°C decomp., [aJo -131.3° (pyridine), a diterpene of the kaurane type bitter principle from Rabdosia trichocarpa and R. ja-ponica shows antitumor and anti-inflammatory activity against Ehrlich ascites tumors and inhibits insect growth. E. can be transformed into numerous other di-terpenes such as abietanes, Aconitum alkaloids, gib-berellins. The biosynthesis proceeds from 16-kaurene. Lit. Agric. Biol. Chem. 43, 71 (1979) Karrer, No. 3712 Zechmeister 46, 77-157. - (CAS3776-39-4]... [Pg.208]

Enhancement of antitumor activity of ascorbate against Ehrlich ascites tumor cells by the copper glycylglycylhistidine complex. Cancer Research 43 (1983) 824—828. (Eiji Kimoto, Hidehiko Tanaka, Junichiro Gyotoku, Fukumi Morishige, and Linus Pauling). [Pg.733]

Both matrine (26) and cytisine (27) have established ame-bicidal activity (Phillipson and O Neill, 1987). Matrine has antitumor activity against Ehrlich ascites tumor (Wink, 1993b). [Pg.559]

Compounds XV-XXI exhibited antitumor activity against Ehrlich ascites tumor. [Pg.112]

All T) -cyclopentadienyl metal complexes listed in Tables 1-3 were investigated against fluid Ehrlich ascites tumor, and antitumor activity of varying strength was detected (Tables 5-7). Some of those compounds, which were characterized by pronounced tumor-inhibiting activity against Ehrlich ascites tumor, were additionally tested against other fluid and solid animal tumors. [Pg.121]

Fig, 10. Dose-activity and dose-lethality relationships of the ferricenium complexes XLIX, LI, LIII and LV against Ehrlich ascites tumor in mice. Hi Surviving animals... [Pg.125]

On the other hand, the tumor inhibition effected by (CsH5)2MX2 compounds was distinctly dependent on the central metal atom M present within the molecules. Whereas the metallocene dichloro complexes I-III and V containing the first-row and second-row transition metals titanium, vanadium, niobium or molybdenum effected pronounced antitumor activity with distinct dose-activity relationships and with cure rates of 100% at optimum doses against Ehrlich ascites tumor the compounds IV and VI with... [Pg.143]

Xanthan gum has been reported to be active against Ehrlich ascites tumor and S-180 in mice, being synergistic with 5-fluorouracil or bleomycin in S-180. ... [Pg.624]

Quinn, R.J., Kashiwagi, M Moore, R.E., and Norton, T.R. (1974) Anticancer activity of zoanthids and the associated toxin, palytoxin, against Ehrlich ascites tumor and P-388 lymphocytic leukemia in mice. /. Pharm. Scl, 63, 257-260. [Pg.1391]

Phenanthrenebiguanides possess 384) some activity against cancer. The effect of biguanides on plasma protein surface has been investigated 294, 610) with a view to the possibility of finding anti-tumor ents. Aryl-and naphthyl-biguanides exhibit 625) a slight anti-neoplastic activity in vitro in Ehrlich ascites carcinoma. [Pg.74]

Genotoxic Effects. Genotoxic Effects. HDI was demonstrated to be non-mutagenic against some Salmonella typhimurium strains with or without metabolic activation (Anderson et al. 1980). HDI also inhibited the growth of Ehrlich ascites tumor eells in female mice (Moos et al. 1971) and decreased the mutation frequency in Escherichia coli (Kawazoe et al. 1981). Calf thymus DNA incubated in vitro with 10.4 or 52 mol of HDI for 10 or 20 minutes produeed no evidence of intrastrand cross-links or DNA strand breaks (Peel et al. 1997). No studies were located that studied the genotoxic effects of HDI on human cells or that deseribed the ability of prepolymer forms of HDI to induce genotoxicity."... [Pg.107]

A violet solution prepared by UV irradiation of a solution of (NH4)2[IrCl6] in ammonia has been reported to show activity against the Ehrlich ascites tumor. The solution, which probably contains both Ir111 and IrIV species, also causes filamentous growth in E. coli. [Pg.758]

Table 10. Antitumor activity of 5-FU and vinyl-type polymeric drugs against Ehrlich s ascites tumor bearing mice"... Table 10. Antitumor activity of 5-FU and vinyl-type polymeric drugs against Ehrlich s ascites tumor bearing mice"...

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See also in sourсe #XX -- [ Pg.209 ]




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