Tromethamine

Chemical Name (5Z,9a, 11a,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid tro-methamine salt 

Common Name Prostaglandin tromethamine Structural Formula  

Trade Name Ma nufacturer Country Year Introduced 

Tris( Hydroxy methyl jaminomethane Prostaglandin F2ct 

Morozowich, W. U.S. Patent 3,657,327 April 18, 1972 assigned to The Upjohn Company 

Common Name Prostaglandin Fjq tromethamine Structural Formula on 

Trade Name Manufacturer Country Year Introduced 

Therapeutic Function Oxytocic abortifacient Chemical Name 11,15-Dihydroxy-9-oxoprosta-5,13-dien-1,oic acid Common Name Prostaglandin Ej, PGE2 Structural Formula p 

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ANGUS Chemical Company is the only basic manufacturer of technical-grade TRIS AMINO (Tromethamine). However, ANGUS and numerous processors offer recrystallized, high purity grades of this alkanolamine for biomedical appHcations. 

Kiening KL. Schneider GH, Unterherg AE, Lanksch WR. Effect of tromethamine (THAM) on infarct volume following permanent middle cerebral artery occlusion in rats. Acta Neurochir 1997 70 188-190. 

Is the arterial pH less than 7.1 If yes, consider administration of sodium bicarbonate 100 to 150 mEq intravenously as slow infusion. Alternatively, consider use of tromethamine intravenously. 

Another option for patients with severe acidemia is tromethamine (THAM). This inert amino alcohol buffers acids and C02 through its amine (—NH2) moiety ... 

GM-CSF) Reconstitution with water Use within 6 hr of reconstitution sargramostim, 40 mg mannitol, 10 mg sucrose, 1.2 mg tromethamine... 

Roseman, T. J. Yalkowsky, S. H., Physical properties of prostaglandin F2a (tromethamine salt) Solubility behavior, surface properties, and ionization constants, J. Pharm. Sci. 62, 1680-1685 (1973). 

Mann and Mitchell [58] described a simple colorimetric method for estimation of (-D)-penicillamine in plasma. Blood containing 2-50 pg of penicillamine was mixed with 0.1 M EDTA solution in tromethamine buffer solution. 0.1 mL of this solution was adjusted to pH 7.4 and centrifuged. To a portion of the plasma was added 3 M HCL, the mixture was freeze-dried, and a suspension of the residue in ethanol was centrifuged. The supernatant liquid was mixed with tromethamine buffer solution (pH 8.2) and 10 mM 5,5 -dithiobis-(2-nitrobenzoic acid) in phosphate buffer solution (pH 7.0), the mixture was shaken with ethyl ether, and the absorbance of the separated aqueous layer was measured at 412 nm. The mean recovery was 60% (four determinations), and the calibration graph was linear for the cited range. 

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