Trichloroacetate

Trichloroacetic acid is best prepared by the oxidation of chloral hydrate with fuming nitric acid ... 

Polybromo compounds (bromoform, s-tetrabromoethane) react similarly at 50°, but simple polychloro compounds (chloroform, carbon tetrachloride and trichloroacetic acid) do not. 

In step 1 of each oligonucleotide-synthesis cycle the 5 -terminal 4,4 -dimethoxytrityl protecting group is removed with trichloroacetic acid, and the support is washed with acetonitrile to prevent dctritylation of the next incoming phosphoramidite. The 4,4 -dimethoxy-... 

An electronegative substituent particularly if it is attached to the a carbon increases the acidity of a carboxylic acid As the data m Table 19 2 show all the mono haloacetic acids are about 100 times more acidic than acetic acid Multiple halogen sub stitution increases the acidity even more trichloroacetic acid is 7000 times more acidic than acetic acid ... 

Learning By Model mg contains mo lecular models of CH3C02 (acetate) and Cl3CC02 (trichloroacetate) Compare these two ions with respect to the amount of negative charge on their oxygens... 

Trichloroacetic acid dissolve 100 g of the acid in water and dilute to 1 liter. 

Another example is the successive reduction of trichloroacetate to dichloroac-etate, and of dichloroacetate to monochloroacetate... 

Mixtures of trichloroacetate and dichloroacetate are analyzed by selecting an initial potential at which only the more easily reduced trichloroacetate is reduced. When its electrolysis is complete, the potential is switched to a more negative potential at which dichloroacetate is reduced. The total charge for the first electrolysis is used to determine the amount of trichloroacetate, and the difference in total charge between the first and second electrolyses gives the amount of dichloroacetate. 

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