Toxic nervous damage

The toxic nervous damage culminates at the end of the second week. Degenerative changes in the dorsal column of the spinal cord occur, and the hyperesthesia may change to ascending paralysis. Toxic effects of thallium on heart muscle and its metabolism result in a distinct and continuous increase in heartbeat. 

Motor vehicle traffic is the main source of anthropogenic lead (Pb) emissions. In humans, toxication causes damage to the nervous system and the kidneys along with other harmful effects (Merian 1991). Lead is preferably absorbed by grass and rape seed. Its content reaches values of more than 5 mg kg-1, while the average lead content of the other plant species is relevantly lower and in some cases below the detection limit. 

Mercury can exist in several forms and all of them are toxic. Thus the element itself is poisonous because hquid mercury vaporizes and the vapour can be inhaled and absorbed. It can enter the brain in this state and cause damage there. The salts of mercury (inorganic mercury) can also be absorbed from the gut and can damage the kidneys. Finally, mercury can exist as organomercury in which it is part of an organic compound. These are also very toxic and damage the brain and nervous system. Mercury is... 

Toxic or poisonous substances are those which injure biological systems causing abnormal and unwanted biochemical or biophysical activity. Toxic chemicals damage tissue, impair the nervous system, or cause serious illness or death in a variety of ways ... 

Toxic liver damage, supportive tteatment in chronic liver diseases, dyspeptic complaints Dyspeptic ailments, appetite stimulant Nervous unrest,... 

Nitric oxide was approved by the FDA in 1999 for use as a vasodilator in the treatment of hypoxic respiratory failure in full- and near-term infants. It is a colorless and essentially odorless gas with a very narrow therapeutic window for patients. Acute exposure effects include mucous membrane irritation and drowsiness. More serious effects include delayed pulmonary toxicity and damage to the central nervous system effects. Exposed employees may seem relatively asymptomatic at the time of exposure. It can take as long as 72 hours to manifest clinical symptoms. OSHA classifies nitric oxide as a highly hazardous substance. 

Effects of repeated ethylene glycol peroral overexposure in treated rats and mice can result in kidney, Hver, and nervous system damage. The most sensitive indicators of ethylene glycol toxicity are disturbances in acid—base balance and nephrotoxic (kidney) effects. Effects of repeated chronic peroral overexposure of diethylene glycol in treated rats result in kidney and Hver damage (48). 

Phenol. Phenol monomer is highly toxic and absorption by the skin can cause severe blistering. Large quantities can cause paralysis of the central nervous system and death. Ingestion of minor amounts may damage kidneys, Hver, and pancreas. Inhalation can cause headaches, dizziness, vomiting, and heart failure. The threshold limit value (TLV) for phenol is 5 ppm. The health and environmental risks of phenol and alkylated phenols, such as cresols and butylphenols, have been reviewed (66). 

Bromothiophenes are toxic materials by aU routes. Inhalation toxicity of 2-bromothiophene is significant. Ecotoxicity is also noted for these materials, particularly for 2-bromo-3-methylthiophene. 2-Thiophenecarboxaldehyde and the 3-methyl derivative can cause minor irritation to the skin and eyes of rabbits. The former is a sensitizer to guinea pig skin, the latter is not. 2-Acetylthiophene is toxic in aU modes of contact. Severe exposure causes serious inflammation of the lung, damage to many organs, and depression of the central nervous system. 

Toxicity of 2-Ghloroethanol. Ethylene chlorohydrin is an irritant and is toxic to the Hver, kidneys, and central nervous system. In addition, it is rapidly absorbed through the skin (73). The vapor is not sufficiently irritating to the eyes and respiratory mucous membranes to prevent serious systemic poisoning. Contact of the Hquid in the eyes of rabbits causes moderately severe injury, but in humans corneal bums have been known to heal within 48 hours. Several human fataUties have resulted from inhalation, dermal contact, or ingestion. One fatahty was caused by exposure to an estimated 300 ppm in air for 2.25 hours. In another fatal case, autopsy revealed pulmonary edema and damage to the Hver, kidneys, and brain (73). 

In nonindustrial settings, MCS substances are the cause of indoor air pollution and are the contaminants in air and water. Many of the chemicals which trigger MCS symptoms are known to be irritants or toxic to the nervous system. As an example, volatile organic compounds readily evaporate into the air at room temperature. Permitted airborne levels of such contaminants can still make ordinary people sick. When the human body is assaulted with levels of toxic chemicals that it cannot safely process, it is likely that at some point an individual will become ill. For some, the outcome could be cancer or reproductive damage. Others may become hypersensitive to these chemicals or develop other chronic disorders, while some people may not experience any noticeable health effects. Even where high levels of exposure occur, generally only a small percentage of people become chemically sensitive. 

Toxicity. Breathing moderate amounts of methyl ethyl ketone (MEK) for short periods of time can cause adverse effects on the nervous system ranging from headaches, dizziness, nausea, and numbness in the fingers and toes to unconsciousness. Its vapors are irritating to the skin, eyes, nose, and throat and can damage the eyes. Repeated exposure to moderate to high amounts may cause liver and kidney effects. 

Cresol is a toxic chemical that can be absorbed via the skin and may cause damage to the kidney, the liver, and nervous system. The objective of this problem is to reduce cresol concentration in any discharged wastewater stream to 5 ppraw or less. 

Neurotoxicity (damage to the nervous system by a toxic substance) may also be seen with the administration of the aminoglycosides. Signs and symptoms of neurotoxicity include numbness, skin tingling, circum-oral (around the mouth) paresthesia, peripheral paresthesia, tremors, muscle twitching, convulsions, muscle weakness, and neuromuscular blockade (acute muscular paralysis and apnea). 

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