Reproductive damage

In nonindustrial settings, MCS substances are the cause of indoor air pollution and are the contaminants in air and water. Many of the chemicals which trigger MCS symptoms are known to be irritants or toxic to the nervous system. As an example, volatile organic compounds readily evaporate into the air at room temperature. Permitted airborne levels of such contaminants can still make ordinary people sick. When the human body is assaulted with levels of toxic chemicals that it cannot safely process, it is likely that at some point an individual will become ill. For some, the outcome could be cancer or reproductive damage. Others may become hypersensitive to these chemicals or develop other chronic disorders, while some people may not experience any noticeable health effects. Even where high levels of exposure occur, generally only a small percentage of people become chemically sensitive. 

Results of studies in animals show that effects of 1,3-DNB and 1,3,5-TNB on the blood are similar to the effects seen in people. Results from animal studies also show some other effects of 1,3-DNB exposure, such as behavioral changes, damaged sperm production, and male reproductive damage. We do not know if these other effects could occur in people. Animal studies also show that, in certain cases, a large enough single oral dose of 1,3-DNB can cause death. Neither 1,3-DNB or 1,3,5-TNB have been tested to see whether or not they cause cancer in animals. 

Toxicology. Nitrotoluene has a low potency for producing methemoglobin and subsequent anoxia. Chronic exposure to other aromatic nitro compounds has caused anemia, and it is expected that nitrotoluene may cause the same effect. Animal data suggest a potential for hepatic, renal, and reproductive damage. 

Trieff NM, Romana LA, Esposito A, et al. 1995. Effluent from bauxite factory induces developmental and reproductive damage in sea urchins. Arch Environ Contain Toxicol 28 173-177. 

Exposure to 2,3,7,8-TCDD can cause reproductive damage and birth defects in animals. 

CHRONIC HEALTH RISKS may cause skin sensitization with irritation, redness, and cholinesterase inhibition may cause mutations (genetic changes) in living cells may possibly cause reproductive damage in humans may be a teratogen in humans damages the male reproductive system decreases sperm count in animals may cause a skin allergy. 

CHRONIC HEALTH RISKS (nickel, nickel compounds) lung and sinus cancer pulmonary fibrosis pulmonary edema asthma skin allergy itching redness and bumps reproductive damage in humans. 

Injection of iodized oil to a cretin couple from a severely iodine deficient area resulted in birth of normal children and prevent reproductive damage. 

Potassium cyanide caused reproductive damage in test animals, producing harmful effects on fertility and embryo. 

Toxicology Prolonged/repeated contact with sidn or eyes can cause irritation excessive inh. may cause nasal/respiiatoiy irritetion, CNS effects, possible unconsciousness, death, reproductive damage ing. of Ig. amts, may cause serious injury TSCA listed Precaution Incompat. with materials which react with water Hazardous Decomp. Prods. Hydrocarbon decomp, prods., silica HMIS Health 1, Rammability 1, Reactivity 0 borage Store below 100 F do not freeze mix well before use... 

Reproductive toxicants that cause damage to the developing fetus resulting in birth defects and abnormalities in the baby (teratogens) or cause effects on the developing fetus in other ways (feto-toxicants). HC lA compounds are known to cause and HC IB are presumed to cause reproductive damage. (See also Section 4.1.2.)... 

In October 2010, the US EPA announced that it had received from the Halogenated Solvents Association (http7Awvw.hsia.org) a petition for the consideration of n-propyl bromide to be a HAP (it can be downloaded from http /Awvw.hsia.org/news(nPBPetitionsigned.pdf). The basis was emissive use by humans, past multiple findings of reproductive damage in exposed laboratory animals, and a recent finding about carcinogenicity. Any US citizen can file similar petitions. 

Reproductive Effects Reproductive damage in humans. Suspect human, teratogen causes birth defects fetal death in rats. Animal studies show damage to reproductive system in males females may be fetotoxic. Suspect human teratogen causes birth defects fetal ath in rats. Causes reproductive damage in men womert causes mutations in animals. 

Toxicology Prolonged/repeated contact with skin or eyes can cause irritation excessive inh. may cause nasal/respiratory irritation, CNS effects, possible unconsciousness, death, reproductive damage ing. of Ig. amts, may cause seri-... 

---