Total reticulocyte count

Hematological Methods. Hematological analyses can Include the determination of the total hemoglobin concentration (In g%), the packed cell volume (PCV In %), the red blood cell count (In 10 /mm ) and reticulocytes count (In %), calculation of the red cell Indices, examination of a blood film, tests to demonstrate the presence of Inclusion bodies and of sickle cells, tests to evaluate the distribution of fetal hemoglobin (Hb-F) Inside the red cells, the red cell osmotic fragility, the concentration of serum Iron (SI), total Iron binding capacity (TIBC), and the survival time of the red cells. Details of all... 

Hemoglobin, hematocrit, reticulocyte count, ferritin and serum iron levels, and total iron-binding capacity... 

Blood tests were performed and had the following results hematocrit 33% (normal is 38%-45%) reticulocyte count 2.0% (normal is 0.5%-1.5%) mean corpuscular volume 90 (normal). A decreased erythrocyte sedimentation rate and a prothombrin time (PT) of 15 s (normal 11-13 s) were noted. A complete blood cell count values for total protein and albumin, ALT, and AST, fasting glucose, Hb-Alc, as well as amylase and lipase were within normal range. Plasma levels of vitamins A and K were below normal, and there was near absence of vitamin E. Dysmorphic red blood cells (RBC) with multiple thorny projections (acanthocytes) were present on a blood smear. All other laboratory tests and findings were within normal limits. 

Reticulocytes were obtained from rabbits made anemic by repeated bleeding. Reticulocyte counts were generally 20-80% of total red cells. Standard methods were followed for preparing and 125I-labeling of rabbit transferrin and its incubation with reticulocytes (54). Reticulocyte membranes were prepared by the method of Dodge (77) and solubilized for... 

Hemoglobin Reticulocyte count Serum bilirubin (total) Serum bilirubin (indirect) Serum haptoglobin Serum iron Urinary iron Fecal stercobilinogen... 

Hematological effects Decreased hemoglobin content and hematocrit, and increased total white blood cell counts, reticulocyte counts, and plasma hemoglobin, intravascular hemolysis, anemia and thrombocytopenia... 

If an anemia is detected further studies including a careful examination of the peripheral smear, reticulocyte count, stool for occult blood, serum iron, total iron binding capacity, bilirubin, and, if appropriate, vitamin B12 and folate may be of value in attempting to identify the cause of the anemia. 

The life span of the normal red blood cell is 120 days this means that slightly less than 1% of the population of red cells (200 billion cells, or 2 million per second) is replaced daily. The new red cells that appear in the circulation still contain ribosomes and elements of the endoplasmic reticulum. The RNA of the ribosomes can be detected by suitable stains (such as cresyl blue), and cells containing it are termed reticulocytes they normally number about 1% of the total red blood cell count. The life span of the red blood cell can be dramatically shortened in a variety of hemolytic anemias. The number of reticulocytes is markedly increased in these conditions, as the bone marrow attempts to compensate for rapid breakdown of red blood cells by increasing the amount of new, young red cells in the circulation. 

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