Raman tomography

Fig. 5.6. A block diagram of an optical coherence tomography/Raman spectroscopy system C, circulator RSOD, rapid scanning optical delay BP, 785 bandpass BSO, beam shaping optics DM1, dichroic mirror at 990 nm DM2, dichroic mirror at 800-950 nm LP, long pass at 808 nm GP, galvanometer pair BD, balanced detector BPF, electronic band-pass filter AI-AO DAQ, analog input-output data acquisition (reprinted with permission from [34]. Copyright 2008 Optical Society of America)...

M.V Schuhnerich, S. Srinivasan, J. Kreider, J., et al., Raman tomography of tissue phantoms and bone tissue, Proc. SPIE-Int Soc. Opt Eng., 6853, 68530V-68530V-7 (2008). 

Chemimage Corporation, Method for Raman computer tomography imaging spectroscopy. Inventors J.S. Maier and P.J. Treado. 9 pp. (incl. 5 fig.). Appl. 20 Jan 2006. Int. Cl. GOIJ 3/44 GOIN 21/65. US Patent Application... 

Diffuse Raman tomography has been demonstrated, with reconstruction of low-definition three-dimensional maps of phantoms and of canine bone tissue [38, 39], Spatial priors (i.e. independent information on the location and... 

Best results are obtained when spatial variation is maximized. For that reason the recovered contrast is over 140 1 when the image reconstruction is based on transmission measurements, but only about 1.4 1 for contrast based on backscattered measurements. It is likely that even better results would be obtained in both image-guided Raman spectroscopy and Raman tomography if illumination and collection fibers were placed strategically around the specimen. 

Key words dental, oral cavity, cancer, microorganisms, materials characterization, enamel, caries, polarized Raman spectroscopy, optical coherence tomography, clinic, fibre optics... 

Abbreviations PRS - polarized Raman spectroscopy, OCT - optical coherence tomography... 

CARS CAT CCD CIF CPMD CT CTAB CW Coherent Anti-Stokes Raman Scattering Computerized Axial Tomography Charge-Coupled Device Chemical Image Fusion Carr-Parrinello Molecular Dynamics Computed Tomography Cetyltrimethylammonium Bromide Continuous Wave (Laser)... 

Raman spectroscopy UV/visible spectroscopy Acoustic Emission spectroscopy Particle size characterization X-ray tomography NMR... 

Nabiev IR, Morjani H, Manfait M (1991) Selective analysis of antitumor drug interaction with living cancer cells as probed by surface-enhanced Raman spectroscopy. Eur Biophys J 19 311 Xiao M, Nyagilo J, Arora V, Kulkami P, Xu DS, Sun XK, Dave DP (2010) Gold nanotags for combined multi-colored Raman spectroscopy and x-ray computed tomography. Nanotechnology 21 1-8... 

Various forms of spectroscopy have been applied to in situ studies of catalysis, and it is appropriate to cite a few examples. FT-IR is frequently employed for in situ investigations. The experimental configurations used can be either transmission studies of free-standing catalyst wafers [2] or diffuse reflectance measurements on samples in catalytic reaction chambers 13]. In situ Raman spectroscopy has also been applied [4]. X-rays have been used to study catalysts in situ, either by powder diffraction methods [5,6] or XAFS [7]. In situ imaging techniques are beginning to be applied to the measurement of spatial distributions and residence times in catalytic reactors. A recent example of this method employed positron-emission tomography [8]. 

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