Optical coherence tomography,

The backscattered light depends on the structure of the sample material. For instance have cancer cells in a biological tissue a different backscattering coefficient than normal cells. They cause a different amplitude and phase of the backscattered light. 

The penetration depth depends on the absorption and scattering coefficients of the sample. It can be maximized by choosing the optimum wavelength. For a wavelength-specific measurement of the spectral characteristic of the sample the broad spectral range of the light source can be dispersed by a prism (Fig. 7.40) and the interference can be measured by a CCD-detector as a function of the wavelength. 

The possibility to investigate the morphology of living tissue with microscopic resolution while optical microscopy needs thin cuts of tissue which can be only prepared as frozen material. 

Instant direct infomation about the morphology of living tissue or other materials 

Applications to medical problems and material sciences are discussed in Chap. 10. 

---

Other diagnostic tests scanning laser polarimetry, confo-cal scanning laser ophthalmoscopy, and optical coherence tomography. 

Chan, A, Ko, TH, and Duker, JS, 2006. Ultrahigh-resolution optical coherence tomography of canthaxanthine retinal crystals. Ophthalmic Surg Lasers Imaging 37, 138-139. 

Optical Coherence Tomography and Optical Coherence Microscopy to Monitor Water Absorption... 

Gelikonov,V.G., Gelikonov, G.V., Ksenofontov, S.Yu., Kuranov, R.V., Morozov, A.N., Myakov, A.V, Turkin, A.A., Turchin, I.V. and Shabanov, D.V. (2003). New approaches in broadband fiber-optical interferometry for optical coherent tomography Radiophysics and Quantum Electronics 46 550-564. 

Sapozhnikova, V.V., Kamensky, V.A., Kuranov, R.V., Kutis, I., Snopova, L.B. and Myakov, A.V. (2004). In vivo visualisation of Tradescantia leaf tissue and monitoring the physiological and morphological states under different water supply conditions using optical coherence tomography. Planta 219 601-609. 

Schmitt, J.M. (1999). Optical Coherence Tomography (OCT) A Review. IEEE Journal on Select Topics In Quantum Electronics 5 1205-1215. 

Shakhova, N.M., Gelikonov, V.M., Kamensky, V.A. and Kuranov, R.V. (2002). Clinical aspects of the endoscopic optical coherence tomography and the ways for improving its diagnostic value. Laser Physics 12 617-626. 

Teamey, G. J., Brezinski, M. E., Bouma, B. E., Boppart, S. A., Pitris, C., Southern, J. R, and Eujimoto, J. G. 1997. In vivo endoscopic optical biopsy with optical coherence tomography. Science 276 2037-39. 

Vinergoni, C., Bredfeldt, J. S., Marks, D. L., and Boppart, S. A. 2004. Nonhnear optical contrast enhancement for optical coherence tomography. Opt. Express 12 3310341. 

Jiang, Y, Tomov, I., Wang, Y, and Chen, Z. 2004. Second-harmonic optical coherence tomography. Opt. Lett. 29 1090-92. 

Eye bums are a process that develops during a chemical or thermal exposure that is of exceeding mass, contact time, chemical reactivity, and temperature until the exhaustion of the protective mechanisms of the eye. The most plastic description of this process can be given in images that are obtained by optical coherence tomography [5]. 

Spoler, E, Erentz, M., Forst, M., Kurz, H., Schrage, N.F. Dynamic analysis of chemical eye bums using high-resolu-tion optical coherence tomography. J Biomed Opt 12(4), 041203 (2007)... 

The decontamination and healing after bums must be subjected to systematic research. Thus we have started with healing in the ex vivo eye irritation assay EVEIT after mechanical and chemical exposures. The healing is monitored by biochemistry and optical coherence tomography. 

Huang, et al. Optical Coherence Tomography. Science, 1178 (November 22, 1991). 

Izatt, J.A., et al. Ophthalmic Diagnostics Using Optical Coherence Tomography, SPDIF. Proceedings, 1877 (1993). 

Subtenon local injection of a glucocorticoid is effective in the treatment of certain forms of uveitis. Central serous chorioretinopathy, confirmed by optical coherence tomography, developed after a single local subtenon glucocorticoid injection to treat HLA-B27-associated iritis (70). 

Fig. 5.6. A block diagram of an optical coherence tomography/Raman spectroscopy system C, circulator RSOD, rapid scanning optical delay BP, 785 bandpass BSO, beam shaping optics DM1, dichroic mirror at 990 nm DM2, dichroic mirror at 800-950 nm LP, long pass at 808 nm GP, galvanometer pair BD, balanced detector BPF, electronic band-pass filter AI-AO DAQ, analog input-output data acquisition (reprinted with permission from [34]. Copyright 2008 Optical Society of America)...

Key words dental, oral cavity, cancer, microorganisms, materials characterization, enamel, caries, polarized Raman spectroscopy, optical coherence tomography, clinic, fibre optics... 

Abbreviations PRS - polarized Raman spectroscopy, OCT - optical coherence tomography... 

---