Expression tissue specific

Tissue-Specific Expression. In adult rodents, PPAR.a is expressed in liver, kidney, intestine, heart, skeletal muscle, retina, adrenal gland, and pancreas. In adult human, PPARa is expressed in the liver, heart, kidney, large intestine, skeletal muscle (mostly slow-twitch oxidative type I fibers), and in cells of atherosclerotic lesions (endothelial cells, smooth muscle cells, and monocytes/macrophages). Therefore, regardless of... 

Tissue-Specific Expression. In the adult rodent, PPARy is expressed in brown and white adipose tissue, and at lower levels in intestine, retina, skeletal muscle, and lymphoid organs. In human, PPARy is most abundantly expressed in white adipose tissue and at lower levels in skeletal muscle, the heart, and liver, but not in lymphoid tissues, although PPARy has been identified in macrophages in human atheromas. 

Tissue-Specific Expression. In the adult rat, PPAR8 is expressed in all tissues examined, and often at levels higher than PPARa and PPARy. In human, PPAR8 is ubiquitously expressed, with higher expression in the digestive tract and placenta. 

Powell, W.R., Bright, S., and Bello, S.M. (2000). Developmental and tissue-specific expression of AHRl, AHR2, and ARNT2 in dioxin-sensitive and -resistant populations of the marine fish—Fundulus heteroclitus. Toxicological Sciences 57, 229-239. 

Hormone response elements (for steroids, T3, retinoic acid, peptides, etc) act as—or in conjunction with— enhancers or silencers (Chapter 43). Other processes that enhance or silence gene expression—such as the response to heat shock, heavy metals (Cd and Zn +), and some toxic chemicals (eg, dioxin)—are mediated through specific regulatory elements. Tissue-specific expression of genes (eg, the albumin gene in liver, the hemoglobin gene in reticulocytes) is also mediated by specific DNA sequences. 

Tissue-Specific Expression May Result From the Action of Enhancers or Repressors... 

QTLs were also detected in tomato introgression lines (domestic tomatoes with single, defined chromosome regions selected from the progeny of a cross with a wild, non-pigmented variety) that correspond to candidate loci for which genes and mutants have been previously characterized. Detected QTLs included the r locus Psy), the Del locus (LcyE), and the B locus. Similar to the tissue-specific expression of maize Yl, the B locus codes a fruit-specific lycopene cyclase associated with higher levels of P-carotene. ... 

Figure 10. Tissue specific expression of p-subunit proteins in floral tissues. Stage 3 (fully opened) flowers were collected, dissected and cell wall proteins (5 pgm) from the indicated organs isolated and analyzed for p-subunit antigen. Note the high level of expression in stigma/style and anthers/pollen and restriction of the larger antigen to stigma/style tissues. PGl lane, 1 gg of purified fruit PGl protein.

TABLE 1 Stage- and tissue-specific expression of a cki-l gfp reporter gene during C. elegans development... 

Zhu, C., F. Kauder et al. (2007). Cloning of two individual cDNAS encoding 9-cw-epoxycarotenoid dioxygenase from Gentiana lutea, their tissue-specific expression and physiological effect in transgenic tobacco. J. Plant Physiol. 164(2) 195-204. 

Duran, E., Walker, D.J., Johnson, K.R., Komuniecki, P.R and Komuniecki, R.W. (1998) Developmental and tissue-specific expression of 2-methyl branched-chain enoyl CoA reductase isoforms in the parasitic nematode, Ascaris suum. Molecular and Biochemical Parasitology 91, 307-318. 

Gould GW, Holman GD. The glucose transporter family structure, function and tissue specific expression. Biochem J 1993 295 329-341. 

An alternative approach to assessing tissue-specific expression at the proteomic level can be achieved by MS of laser capture microdissected tissues.4 An important development in this arena is the ability to perform LCM and MS/MS on formalin-fixed paraffin-embedded tissues. 

Maclnnes, J. I., Nozik, E. S. and Kurtz, D. T. (1986) Tissue-specific expression of the rat alpha 2u globulin gene family. Mol. Cell. Biol. 6, 3563-7. 

A. Gaedigk, J. S. Leeder, D. M. Grant, Tissue-Specific Expression and Alternative Splicing of Human Microsomal Epoxide Hydrolase , DNA Cell Biol. 1997, 16, 1257 -1266. 

Glickman, M., Malek, R.L., Kwitek-Black, A.E., Jacob, H.J. and Lee, N.H., 1999, Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein-coupled receptor, nrg-1, Mol. Cell. Neurosci. 14 141-152. 

Tissue-specific expression of HMGN family members in vivo... 

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