Gene expression tissue specific

The concentration of mRNA available for translation is determined by the de novo synthesis, as well as by the degradation rate. The specific degradation of mRNAs plays an important role in cell- and tissue-specific gene expression (review Sachs, 1993). The stabUity of various mRNAs can vary significantly from 20 min to 24 hour half-life in the same cell. 

Bailey-Serres, J., Kloeckner-Gruissem, B. Freeling, M. (1988). Genetic and molecular approaches to the study of the anaerobic response and tissue specific gene expression in maize. Plant, Cell and Environment 11, 351-7. 

R. G. Vile, R. M. Diaz, N. Miller, S. Mitchell, A. Tuszyanski, and S. J. Russell, Tissue-specific gene expression from Mo-MLV retroviral vectors with hybrid LTRs containing the murine tyrosinase enhancer/promoter, Virology 214 307 (1995). 

Stein, G. S., Lian, J. B., and Owen, T. A., Relationship of cell growth to the regulation of tissue-specific gene expression gene expression during osteoblast differentiation. FASEB J. 4, 3111-3123 (1990). 

Most of the control of tissue-specific gene expression occurs at the level of transcription this is achieved with tissue-specific transcription factors. For example, all genes that are to be expressed in erythroid cells, e.g., globin, spectrin, and erythropoietin receptor, have the site -AGATA- in their promoters. This site binds to a transcription factor (called GATA-l) which is present only in erythroid cells, and the promoter will function only in the presence of this factor. 

Kleming, R. E and Gitlin, J. D. (1990). lYimary structure of rat ceruloplasmin and analysis of tissue-specific gene expression during development. /. Biot, Chem. 265,7701-7707. 

Fraser, P.D., Truesdale, M.R., Brid, C.R., Schuch, W., and Bramley, P.M. 1994. Carotenoid biosynthesis during tomato fruit development (evidence for tissue-specific gene expression). Plant Physiol. 105, 405 413. 

Diagnosis of Tumors, Micrometastases, Isolated and Circulating Tumor Cells by Molecular Detection of Tissue-Specific Gene Expression... 

Other important monitoring parameter for thyroid carcinoma is the presence of tumor cells in bone marrow or the circulation of tumor cells in peripheral blood. For the detection of these tumor cells, molecular methods based on the detection of tissue-specific gene expression are developed. The most efficient molecular marker is mRNA encoding to the thyroid-specific hormone thyroglobulin (Tg), a further target is mRNA encoding specific enzymes involved in the synthesis of thyroid hormones such as thyroid peroxidase (TPO). Thyroid transcription factor-1 (TTF-1) is another thyroid-specific marker, which can be used for the diagnosis of thyroid tumors. 

Yamauchi, K., and A. Ishihara. 2009. Evolutionary Changes to Transthyretin Developmentally Regulated and Tissue-Specific Gene Expression. Febs J 276, no 19 5357-66. 

Noninvasive Imaging Strategies to Visuaiize Tissue-Specific Gene Expression Using Transcriptionai Ampiification Approaches... 

---