Genes Globulin

McFadyen D. and Addison-Wand J.L. (1999). Genomic organization of the rat alpha 2p-globulin gene cluster. Mamm Genome 10, 463-470. 

Kulkarni, A. B., Gubits, R. M. and Feigelson, P. (1985) Developmental and hormonal regulation of alpha 2u-globulin gene transcription. Proc. Natl. Acad. Sci. U S A 82, 2579-82. 

Maclnnes, J. I., Nozik, E. S. and Kurtz, D. T. (1986) Tissue-specific expression of the rat alpha 2u globulin gene family. Mol. Cell. Biol. 6, 3563-7. 

Weiler, E. (1965). Differential activity of allelic y-globulin genes in antibody-producing cells. Proc. Natl. Acad. Sci. USA 54, 1765-1772. 

Kriz, A.R., Wallace, M.S. Paiva, R. (1990). Globulin gene expression in embryos of maize viviparous mutants. Plant Physiology 92, 538-42. 

The pattern of exons and introns (exon-intron-exon-intron-exon) in the a and /3 families of genes is quite old and apparently developed before the separation of these genes some 500 million years ago. The role of introns is unknown, although their base sequences vary. Because the introns are not transcribed, the protein sequences are unchanged. The introns appear to correspond to structural domains within the folded globulin subunits and are requisite for the posttranscriptional processing of mRNA. 

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