Solute carrier

Fatty acid transport protein paralogues 1-6 FATP 1-6 Gene symbols SLC27A1-6 Solute carrier family 27A Very long-chain acyl-CoA synthetase VLCS... 

Neurotransmitter transporters Members of the family of solute carriers Products of the (solute carrier) SLC1, SLC6, SLC17, SLC18, and SLC22 gene families... 

Carrier-mediated transport is linear with mucosal solute concentration until this concentration exceeds the number of available carriers. At this point the maximal solute flux (7max) is independent of further increases in mucosal solute concentration. In the linear range of solute flux versus mucosal concentration (C), the proportionality constant is the ratio of / to the solute-carrier affinity constant (Km). This description of Michaelis-Menten kinetics is directly analogous to time changes in mass per unit volume (velocity of concentration change) found in enzyme kinetics, while here the appropriate description is the time change in solute mass per unit surface area of membrane supporting the carrier. 

Oligopeptide transporter (Solute carrier family 15, member 1 (SLC15A1))... 

SLC2 (solute carrier) superfamily consists of 12 glucose transporters (GLUT1-12) and one H+-myo-inositol cotransporter (HMIT or GLUT13). They all have 12 transmembrane segments with the N- and C-termini both on the cytoplasmic aspect and a specific N-linked oligosaccharide side-chain on either the first or fourth extracellular loop. 

In the steady-state approach (equations (35) and (36)), no attempt is made to isolate the adsorption step from the internalisation of solutes. In this case, a Langmuir adsorption via membrane carriers is coupled to an irreversible and rate-limiting internalisation of the solute carrier complex [186], The process can be described by the Michaelis-Menten equation ... 

Palmiter, R.D. and Huang, L. (2004) Efflux and compartmentalisation of zinc by members of the SLC30 family of solute carriers, Pflugers Arch. Eur. J. Physiol., 447, 744-751. 

Figure 15.1 Schematic illustration of the extended phase concept during drug elimination in the kidney and liver. Phase 0 = uptake of drugs from the blood into the hepatocytes or proximal tubule epithelial cells. This uptake is mediated by transport proteins belonging to the SLC (solute carrier) transporter superfamily. Phase I and...

In the renal epithelium, many uptake transporters are localized in the basolateral membrane and efflux transporters are localized in the apical membrane (Figure 15.2). As a result, vectorial transport of endogenous substances and of drugs from the blood into the urine is achieved. The important uptake transporters are members of the SLC22 family of solute carriers, especially the family members OCT2 and OAT2, which are highly expressed in human kidney. 

Hediger, M.A., Romero, M.F., Peng, J.B., Rolfs, A., Takanaga, H. and Bruford, E.A. (2004) The ABCs of solute carriers physiological, pathological and therapeutic implications of human membrane transport proteins. Pflugers Archiv, 447, 465-468. 

Other solute transporters (solute carrier protein [SLC]) are also expressed in the alveolus. The mRNA transcripts of glucose transporters, GLUT1, GLUT4, GLUT5 and SGLT1, have been detected in freshly isolated rat ATII cells by... 

Diffusion of the solute-carrier complex, QP into the emulsion globule... 

Species/Solute Carrier Internal reagent Co/Coimter transport of ion LM type Mathematical model Inference Reference... 

The diffusion of the solute-carrier complex in the emulsion is described by Pick s second law and is given by the following equation ... 

Step 1 the P ion, after diffusing to the feed-SLM interface, reacts with QCl (Eq. 4) forming a solute-carrier complex, QP CL ions are simultaneously released into the feed solution (coupled transport). 

Carrier and solute-carrier complex dissolve in organic phase only. 

The concentration of solute-carrier complex on the M/R interface is much lower than on F/M interface. 

As noted in Chapter 1, several large families of transport proteins have been identified. The most important of these are the ABC (ATP-Binding Cassette) and SLC (SoLute Carrier) transporter families. As indicated by the name, the ABC carriers utilize ATP for transport. The SLC proteins are cotransporters and in most cases, use the movement of sodium down its concentration gradient as the energy source. Under some circumstances, they also transport transmitters in the reverse direction in a sodium-independent fashion. 

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