Polycythaemia vera

Weinfeld A, Swolin B, Westin J. Acute leukaemia after hydroxyurea therapy in polycythaemia vera and allied disorders prospective study of efficacy and leukae-mogenicity with therapeutic implications. Eur J Haematol 1994 52 134-139. 

Treatments of diseases such as osteoporosis, rickets and osteomalacia, in which there is a disturbance of phosphate levels, is complicated by the interdependence of calcium metabolism. This topic has recently been discussed in relation to clinical medicine21. There is the further difficulty that absorption of phosphate from the bowel can be decreased in the presence of calcium or aluminium salts because of the formation of their insoluble phosphates. Uptake of phosphate by bone is exploited in the treatment of polycythaemia vera by intravenous injection of 32P as sodium phosphate. The resulting irradiation of the neighbouring red bone marrow diminishes the production of red cells. 

Diehn F, Tefferi A. Pruritus in polycythaemia vera prevalence, laboratory correlates and management. Br J Haematol 2001 115 619-21. 

Liver involvement in Osier-Vaquez disease is rare or not detectable at all. There is, however, evidence of hepato-splenomegaly due to extramedullary haemopoiesis. Of importance here is the association with Budd-Chiari syndrome and veno-occlusive disease. Polycythaemia vera should be considered in cases of aetiologically unclarified portal vein thrombosis. 

Lupus anticoagulant Myeloproliferative disease (31) Paroxysmal nocturnal haemoglobinuria Polycythaemia vera Protein C deficiency (68)... 

CHROMOSOME ABNORMALITIES AFTER CHLORAMBUCIL THERAPY UF POLYCYTHAEMIA VERA SCANO J HAEMATOL 17UI 197-2J SEP 1976... 

The clinical course of polycythaemia rubra vera (PRV) is marked by a high risk of thrombotic complications and a variable incidence of transformation to myelofibrosis or acute myeloblastic leukaemia. The object of treatment is to minimise the risk of thrombosis and to prevent transformation. The following are used. 

---