Diseases structure

Tao, Y. X. (2006) Inactivating mutations of G protein-coupled receptors and diseases structure-function insights and therapeutic implications. Pharmacol. Ther. Ill, 949-973. 

These results are consistent with the morphological findings reported in postmortem brains of patients with schizophrenia (i.e., decrease number of spines in prefrontal cortex (Garey et al., 1998 Glantz and Lewis, 2000 Rosoklija et al., 2000 Kolluri et al., 2005), and thus could be related to the deficit in synaptic connectivity assumed to underlie the disease (structural misconnectivity), leading to cognitive deficits. 

Hambleton P. Clostridium botulinum toxins a general review of involvement in disease, structure, mode of action and preparation for clinical use. J Neurol 1992 239(l) 16-20. 

R322 A. N. Ferentz and G. Wagner, NMR Spectroscopy A Multifaceted Approach to Macromolecular Structure , Q. Rev. Biophys., 2000, 33, 29 R323 J. A. Ferretti, The Homeobox and Genetic Disease Structure and Dynamics of Wild Type and Mutant Homeodomain Proteins , J. Biochem. Mol. Biol., 2001, 34, 1... 

The isolation of avenacins A-1, A-2, B-1 and B-2, chemical defences against cereal take-all disease. Structure of the aglycones, the avenestergenins and their anhydro dimers, M.J. Begley, L. Crombie, W.M.L. Crombie and D.A. Whiting, J. Chem. Soc., Perkin Trans 1, 1986, 1905. 

Symptom/Suspected Disease Structures Antibody Locations ... 

ABT-594, a nicotinic acetylcholine receptor (nAChR) modulator that exhibits potent antinociceptive activity in animal models of pain, was discovered through optimization of a series of compounds that was first identified as part of a program directed toward the discovery of nAChR modulators for Alzheimer s disease. Structure-activity studies on ABT-594 indicate that both the azetidine ring and an appropriately substituted pyridine ring are key structural features contributing to its biological activity, which together with its favorable pharmacokinetic and safety profiles, has led to its advancement to clinical trials for treatment of pain in humans. 

Ulrich RG, Bavari S, Olson M. Bacterial superantigens in human diseases Structure, function and diversity. Trends Microbiol. 1995 3 463-468. 

AEvarsson A, et al. Crystal structure of human branched-chain alpha-ketoadd dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease. Structure. 2000 8(3) 277-91. 

It provides detailed information on cardiac structure (atrial and ventricular cavity dimensions, areas, volumes, wall thickness, and mass), cardiac function (systolic and diastolic, right and left ventricular wall motion, fractional shortening and ejection fraction, global and regional, and preload and afterload), valvular disease (structure, function, and degree of regurgitation or stenosis), vascular structures, and hemodynamic data. 

Papaleo, E., 8c Invernizzi, G. (2011). Conformational diseases Structural studies of aggregation of polyglutamine proteins. Current Computer-Aided Drug Design, 7, 23. 

In this section, we will give an example of how physical modeling with experimental verification can be achieved. Specifically, we will describe the plaque dome model as a sound-generating arterial disease structure. We will demonstrate that it may be possible to classify the severity and time progression of disease by means of acoustic modeling of vascular sound. 

Two mechanisms of vascular sound associated with a diseased artery are presented. These acoustic properties of each mechanism will also be specified. The relationship between disease structure and sound features will also be identified. It will be shown that more precise knowledge of the acoustic characteristics of stenotic artery sound can lead to more sensitive detection methods. 

FIGURE 23.11 Sound recording from the free wall latex tubing model of plaque dome disease structure. 

The process of target identification analyzes a complex disease process by dissecting it into its fundamental components. This makes it possible to identify the one that is most integral to the manifestation of the disease. Target identification aims to understand the biological processes related to a disease, and to identify its mechanism and the structure of individual elements of the disease. Commonly these individual elements are receptors, enzymes, etc., which become the target of new drugs. 

Pemtz M 1992. Protein Structure. New Approaches to Disease And Therapy. New York, W H Freeman. Schulz G E and R H Schirmer 1979. Principles of Protein Structure. New York, Springer-Verlag. 

Pellagra is a disease caused by a deficiency of niacm (C6FI5NO2) in the diet Niacin can be synthesized in the laboratory by the side chain oxidation of 3 methylpyndine with chromic acid or potassium permanganate Suggest a reasonable structure for niacin... 

Isolation and Structure Determination. The isolation and stmcture elucidation of vitamin D are closely related to the efforts to understand and cure tickets and related bone diseases. The advent of the use of soft coal, the migra tion of people to cities, and the tendency of people and animals to spend less time in sunshine caused a decline in the abiUty of populations to synthesize sufficient quantities of vitamin D. This led to the increased incidence of tickets, beginning around the mid-1600s (3). 

Perutz, M. Protein Structure New Approaches to Disease and Therapy. New York Freeman, 1992. 

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