Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

The NMDA Receptor

In addition to halopeiidol, the putative neuroleptics, limcazole (311), lemoxipiide (312), and gevotioline (313) bind to (7-ieceptois as does the dopamine uptake blocker, GBR 12909 (314) and two ligands active at the NMDA receptor, ifenprodil (315) and CNS 1102 (316). NPC 16377, (317) is a selective (7-teceptor ligand. MAO inhibitors and antidepressants also bind to (7-teceptors. Some evidence indicates that (7-teceptors in the brain are in fact a form of cytochrome which may account for the diversity of ligands interacting with (7-sites. [Pg.573]

Grb-2 facilitates the transduction of an extracellular stimulus to an intracellular signaling pathway, (b) The adaptor protein PSD-95 associates through one of its three PDZ domains with the N-methyl-D-aspartic acid (NMDA) receptor. Another PDZ domain associates with a PDZ domain from neuronal nitric oxide synthase (nNOS). Through its interaction with PSD-95, nNOS is localized to the NMDA receptor. Stimulation by glutamate induces an influx of calcium, which activates nNOS, resulting in the production of nitric oxide. [Pg.16]

NMDA (iV-methyl-D-aspartic acid) is a synthetic derivative of aspartic acid and represents the prototypical agonist at the NMDA receptors for which the latter were named. [Pg.861]

O Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL (2006) Human immunodeficiency virus (HIV)-induced neurotoxicity roles for the NMDA receptor subtypes. J Neurosci 26 981-990... [Pg.247]

Toggas SM, Masliah E, Mucke L (1996) Prevention of HIV-1 gpl20-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. Brain Res 706 303-307... [Pg.249]

The NMDA receptors come in four main flavours depending on which NR2 subunit (or subunits) is involved in forming the receptor (Table 3.2). Functional NMDA receptors result from the co-assembly of one or more members of three different subfamilies of subunits NRl, NR2 and NR3. [Pg.67]

The NMDA receptor has a heteromeric structure composed of two subunit types NRl and NR2, the latter having four subunits (NR2A-NR2D) (Fig. 10.2). Molecular genetic techniques have demonstrated that native NMDA receptors are likely to be composed of a combination of the NRl subunit (which can exist in eight different splice variants) and one or more of the four NR2 subunits which are the main determinants of functional diversity among the NMDA receptors (see Chapter 3 for further details). It has been shown that there are distinct developmental and spatial expression patterns of NMDA receptor NRl subunit splice variants and NR2 receptor subunits in the CNS. [Pg.216]

Figure 10.4 Structures of some antagonists at the various receptors for glutamate. CNQX is an AMPA antagonist but NQQX has greater selectivity. AP-5 is an NMDA receptor antagonist while MK-801 blocks the NMDA receptor channel (non-competitive)... Figure 10.4 Structures of some antagonists at the various receptors for glutamate. CNQX is an AMPA antagonist but NQQX has greater selectivity. AP-5 is an NMDA receptor antagonist while MK-801 blocks the NMDA receptor channel (non-competitive)...
Finally, AIDS dementia has parallels with cerebral ischemia or stroke and again the key mechanism appears to involve overactivation of glutamate receptors, in particular the NMDA receptor, followed by excessive influx of calcium and the generation of free radicals. [Pg.222]

While there are some reports of increased NMDA and non-NMDA receptor number in various cortical regions of schizophrenics including the prefrontal cortex, there are also indications of impaired glutamate innervation, such as reduction in its neuronal uptake sites (Ishimaru, Kurumaji and Torn 1994). Also it has been found that levels of the mRNA for the NRI subunit of the NMDA receptor in the hippocampus and its D-aspartate binding sites in the temporal cortex are both reduced more on the left than right side in schizophrenic brain. This is another indication of greater malfunction on the left side of the brain and the possibility that some schizophrenic symptoms arise from an imbalance between cross-cortical activity. [Pg.358]


See other pages where The NMDA Receptor is mentioned: [Pg.551]    [Pg.484]    [Pg.553]    [Pg.660]    [Pg.660]    [Pg.660]    [Pg.837]    [Pg.853]    [Pg.1045]    [Pg.13]    [Pg.188]    [Pg.232]    [Pg.282]    [Pg.272]    [Pg.277]    [Pg.23]    [Pg.29]    [Pg.234]    [Pg.75]    [Pg.60]    [Pg.66]    [Pg.68]    [Pg.215]    [Pg.216]    [Pg.217]    [Pg.217]    [Pg.217]    [Pg.218]    [Pg.218]    [Pg.219]    [Pg.219]    [Pg.220]    [Pg.222]    [Pg.256]    [Pg.282]    [Pg.284]    [Pg.317]    [Pg.340]    [Pg.388]    [Pg.420]   


SEARCH



NMDA

NMDA receptors

© 2024 chempedia.info