Uptake, dopamine

In addition to halopeiidol, the putative neuroleptics, limcazole (311), lemoxipiide (312), and gevotioline (313) bind to (7-ieceptois as does the dopamine uptake blocker, GBR 12909 (314) and two ligands active at the NMDA receptor, ifenprodil (315) and CNS 1102 (316). NPC 16377, (317) is a selective (7-teceptor ligand. MAO inhibitors and antidepressants also bind to (7-teceptors. Some evidence indicates that (7-teceptors in the brain are in fact a form of cytochrome which may account for the diversity of ligands interacting with (7-sites. 

Wagner, G.C. Ricaurte, G.A. Johanson, C.E. Schuster, C.R. and Seiden, L.S. Amphetamine induces depletion of dopamine and loss of dopamine uptake sites in caudate. Neurology 20 547-550. 1980. 

HT2 serotonin receptors sites Dopamine uptake sites ... 

Hitori, A. Suddath, R.L. and Wyatt, R.J. Effect of chronic cocaine withdrawal on dopamine uptake sites in the rat frontal cortex. Biol Psychiatry 25 (Suppl) 48A, 1989. 

The neurotoxic effects of all these compounds are antagonized by inhibitors of monoamine uptake (table 1), implicating the membrane uptake carrier on serotonin and dopamine neurons in the mechanism of neurotoxicity. In this regard, these amphetamines are like a drug somewhat related in structure, namely l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP), a Parkinsonism-causing neurotoxic dmg that has been studied intensely since 1983 (Langston and Irwin 1986). In the case of MPTP, the mechanism by which inhibitors of the dopamine uptake carrier block the neurotoxicity toward dopamine neurons (mainly nigrostriatal dopamine neurons) seems clear. A metabolite of MPTP, l-methyl-4-phenylpyridinium (MPP-I-), has been shown to be a substrate for the dopamine uptake carrier (Javitch et al. 1985). Thus accumulation of MPP-I-, formed metabolically from... 

A fourth approach to evaluating the intactness of dopamine and/or serotonin neurons in human subjects who have taken one of the amphetamine analogs might be to use a probe for labeling a constituent of those neurons in position emission tomography scanning studies. A label for the serotonin or dopamine uptake carrier, or a label for tryptophan hydroxylase or tyrosine... 

Schmidt, C., and Loveberg, W. In vitro demonstration of dopamine uptake by neostriatal serotonergic neurons of the rat. Neurosci Lett 59 9-14,... 

Male Sprague-Dawl ey rats (200 -300 gm) were used in all experiments. Dopamine uptake was measured using the accumulation of tritium into a striatal synaptosomal fraction in the presence of an MAO inhibitor following a 5-minute incubation period with 10 nM 3H-DA at 37 °C. Uptake at 2 °C was used as a control for uptake by diffusion and was subtracted from uptake at 37 °C. 

Johnson, K.M., and Snell, L.D. Effects of phencyclidine (PCP) -like drugs on turning behavior, 3H-dopamine uptake, and 3H-PCP-binding. Pharmacol Biochem Behav 22 731-735, 1985. 

Ferraro L., Antonelli T., O Connor W. T. el al (1997). Modaflnil an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers. Biol. Psychiatry 2, 1181-3. 

Mignot E., Nishino S., Guilleminault C., Dement W. C. (1994). Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep 17, 436-7. 

Snyder, S.J. and Coyle, J.T., Regional differences in pH]norepinephrine and pH]dopamine uptake into rat brain homogenates, J. Pharmacol. Exp. Then, 165, 78, 1969. 

Horn, A.S., Dopamine uptake a review of progress in the latest decade, Prog. Neurobiol., 34, 387, 1990. 

Cao, C.J., Shamoo, A.E., and Eldefrawi, M.E., Cocaine-sensitive, ATP-dependent dopamine uptake in striatal synaptosomes, Biochem. Pharmacol., 39, 49, 1990. 

Zimanyi, I., Lajitha, A., and Reith, M.E.A., Comparison of characteristics of dopamine uptake and mazindol binding in mouse striatum, Naunyn-Schmiedeberg s Arch. Pharmacol., 240, 626, 1989. 

Amejdki-Chab, N., Costentin, J., and Bonnet, J. J., Kinetic analysis of the chloride dependence of the neuronal uptake of dopamine and effect of anions on the ability of substrates to compete with the binding of the dopamine uptake inhibitor GBR 12783, J. Neurochem., 58, 793, 1992. 

Krueger, B.K., Kinetics and block of dopamine uptake in synaptosomes from rat caudate nucleus, J. Neurochem., 55, 260, 1990. 

McElvain, J.S. and Schenk, J.O., A multisubstrate mechanism of striatal dopamine uptake and its inhibition by cocaine, Biochem. Pharmacol., 43, 2189, 1992. 

Heikkila, R.E., Cabbat, F.S., and Duviosin, R.C., Motor activity and rotational behavior after analogs of cocaine correlation with dopamine uptake blockade, Commun. Psychopharm., 3, 285, 1979. 

Heikkila, R.E., Manzino, L., and Cabbat, F.S., Stereospecific effects of cocaine derivatives on 3H-dopamine uptake correlations with behavioral effects, Subst. Use Misuse, 2, ff5, f98f. 

Kennedy, L.T. and Hanbauer, I., Sodium-sensitive cocaine binding to rat striatal membrane possible relationship to dopamine uptake sites, J. Neurochem., 41, 172, 1983. 

Dubocovich, M.L. and Zahniser, N.R., Binding characteristics of dopamine uptake inhibitor [3H]nomifensine to striatal membranes, Biochem. Pharmacol., 34, 1137, 1985. 

Anderson, P.H., Biochemical and pharmacological characterization of pH]GBR 12935 binding in vitro to rat striatal membranes labeling of the dopamine uptake complex, J. Neurochem., 48, 1887, 1987. 

Schoemaker, H., Pimoule, C., Arbilla, S., Scatton, B., Javoy-Agid, R, and Langer, S.Z., Sodium dependent pH]cocaine binding associated with dopamine uptake sites in the rat striatum and human putamen decrease after dopamine denervation and in Parkinson s disease, Naunyn-Schmiedeberg s Arch. Pharmacol., 329, 227, 1985. 

Pogiin, S., Scheffel, U., and Kuhar, M.J., Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909, Eur. J. Pharmacol., 198, 203, 1991. 

Schmidt, C.J. and Gibb, J.W., Role of the dopamine uptake carrier in the neurochemical response to methamphetamine effects of amfonelic acid, Eur. J. Pharmacol., 109, 73, 1985. 

Das, D., Rogers, J., and Michael-Titus, A.T., Comparative study of the effects of mu, delta and kappa opioid agonists on 3H-dopamine uptake in the rat striatum and nucleus accumbens, Neuropharmacology, 33, 221, 1994. 

Mount, H., Boksa, P., Chadieu, I., and Quirion, R., Phencyclidine and related compounds evoked [3H] dopamine release from rat mesencephalon cell cultures by mechanisms independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site, Can. J. Physiol. Pharmacol., 68,1200,1990. 

Baba, A., Yamamoto, T., Yamamoto, H., Suzuki, T., and Moroji, T., Effects of the major metabolite of phencyclidine, the trans isomer of 4-phenyl-4-(l-piperidinyl) cyclohexanol, on [3H]N-(l-[2-thie-nyl]cyclohexyl)-3,4-piperidine([3H TPC) binding and [3H] dopamine uptake in the rat brain, Neurosci. Lett., 182, 119, 1994. 

Woodward, J.J., Mansbach, R., Carroll, F.I., and Balster, R.L., Cocaethylene inhibits dopamine uptake and produces cocaine-like actions in drug discrimination studies, Eur. J. Pharmacol., 197, 235, 1991. 

Dwoskin, L.P., Leibee, L.L., Jewell, A.L., Fang, Z., and Crooks, P.A., Inhibition of [3H]dopamine uptake into rat striatal slices by quaternary V-methylated nicotine metabolites, Life Sci., 50, PL-223, 1992. 

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