Design statistics

Figure 4.33 Separation of nine substituted naphthalenes using the sixture-design statistical technique to optimize the composition of the mobile phase (Reproduced with permission from ref. 480. Copyright John Wiley and Sons).

Glajch, J. L., Kirkland, J. J., Squire, K. M., and Minor, J. M., Optimization of solvent strength and selectivity for reversed-phase liquid chromatography using an interactive mixture-design statistical technique, /. Chromatogr., 199, 57, 1980. 

The Snyder-solvent-selectivity triangle concept can be combined with a mixture-design statistical technique to define the optimum mobile-phase composition for a particular separation A feature of this mixture-design... 

Meals were consumed by the subjects following a Latin Square Design. Statistical analysis was performed by a General Linear Models Procedure (20) using split-plot in time analysis with the following non-orthogonal contrasts ... 

Charney DS, Deutch AY, Krystal JH, et al Psychobiologic mechanisms of posttraumatic stress disorder. Arch Gen Psychiatry 50 294-305, 1993 Chassen JB Intensive design statistics and the single case, in Research Designs and Methods in Psychiatry. Edited by Fava M, Rosenbaum JF. Amsterdam, Elsevier, 1992, pp 173-183... 

Other problems pointed out by Box et al. [20] are serially correlated errors, dynamic relations and feedback. All the above problems can be overcome by the use of properly designed statistical experiments that employ features such as randomisation, blocking and other suitable controls. 

Summarising, to optimise the partition coefficient P of a solute i, P, should be maximised by mixing three solvents in the correct proportions. The use of mixture design statistical techniques with the natural logarithm of the partition coefficient as response criterion is a valid way to achieve this. 

Dean, B.J. Johnstone, A. (1977) Dominant lethal assays in male mice evaluation of experimental design, statistical methods and the sensitivity of Charles River (CDI) mice. Mutat. Res.. 42. 269-278... 

Key words Toxicity testing, pre-clinical development, inbred strain, drug development, factorial experimental designs, statistics, signal/noise ratio. 

Chen, H. (1998). Some projective properties of fractional factorial designs. Statistics and Probability Letters, 40, 185-188. 

Kelly, H. W. and Voelkel, J. O. (2000). Asymptotic-power problems in the analysis of supersaturated designs. Statistics and Probability Letters, 47, 317-324. 

Glajch, J.L. Kirkland, J.J. Snyder, L.R. Practical optimization of solvent selectivity in liquid-sohd chromatography using a mixture-design statistical technique. J. Chromatogr. 1982, 238, 269-280. 

The proposed US EPA weight-of-evidence (WOE) scheme for suspect developmental toxicants defines three levels of confidence for data used to identify developmental hazards and to assess the risk of human developmental toxicity (1) definitive evidence for human developmental toxicity or for no apparent human developmental toxicity, (2) adequate evidence for potential human developmental toxicity or no apparent potential human developmental toxicity, and (3) inadequate evidence for determining potential human developmental toxicity. The scheme may require scientific judgment based on experience to weigh the implications of study design, statistical analyses, and biological significance of the data. 

DESIGN STATISTICAL SAMPLING PROGRAMME (including modeiling programmes for physicai processes)... 

Planning of experiments and analysis by statistical methods will furnish precise and detailed answers only if precise and detailed questions are posed to the experimental system. For chemical problems, such questions are of chemical origin. Experimental design can therefore never substitute chemical reason or knowledge. With a good experimental design, statistics will provide the chemist with efficient tools ... 

MONITORING SUB- PROGRAMMES TYPES OF STATISTICAL DESIGN STATISTICAL CRITERIA OF DESIGN ... 

Overlapping resolution mapping (ORM). ORM is a development of the optimisation strategy detailed above and uses mixture design statistical techniques. The approach involves the following steps ... 

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