Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Technetium sestamibi

NCI00100 (Nycomed, Oslo, Norway) is composed of stabilized perfluorocarbon microbubbles. In a randomized comparison of technetium sestamibi single-photon emission-computed tomography (SPECT) and NClOOlOO in the assessment of myocardial perfusion in 203 patients with myocardial infarction, NClOOlOO was well tolerated, with no serious adverse events or deaths (10). Similarly there were no clinically important changes in vital signs, laboratory parameters, or electrocardiography. NClOOlOO correctly identified the vast majority of normally perfused segments assessed by SPECT. [Pg.3544]

In addition to assessing prognosis in stable patients, nuclear perfusion imaging has been used in a prospective manner to help risk-stratify survivors of acute myocardial infarction. Mahmarian et al. (33) used the extent of total and ischemic perfusion defect size (PDS) on adenosine " Technetium sestamibi scans to stratify patients into low-, middle-, and high-risk groups, with... [Pg.69]

Technetium-9 9m sestamibi is used in myocardial perfusion imaging for the evaluation of ischemic heart disease. It is prepared from a lyophilized kit containing tetrakis(2-methoxy isobutyl isonittile) copper(I) tetrafluoroborate stored under nitrogen. Upon reconstitution with up to 5.6 GBq (150 mCi) of 99mTc pertechnetate, the product is formed by boiling for 10 minutes. [Pg.483]

Stress myocardial perfusion imaging with the radionuclides technetium-99m sestamibi or thallium-201 allows for the identification of multivessel disease and assessment of myocardial viability. [Pg.68]

Berman DS, Kiat H, Friedman JD, Wang FP, van TK, Matzer L et al. Separate acquisition rest thallium-201/ stress technetium-99m sestamibi dual-isotope myocardial perfusion single-photon emission computed tomography a clinical validation study. J Am Coll Cardiol 1993 22 1455-1464... [Pg.33]

Sawada SG, Allman KC, Muzik O, Beanlands RS, Wolfe ER, Jr., Gross M et al. Positron emission tomography detects evidence of viabiUty in rest technetium-99m sestamibi defects. J Am Coll Cardiol 1994 23 92-98... [Pg.36]

Hexakis(2-methoxyisobutylisonitrile)technetium-99m (commonly known as [99mTc]Sestamibi) (20a), although originally developed as a radiopharmaceutical for myocardial perfusion imaging [59,60], was the first metal complex... [Pg.165]

Binder T, Assayag P, Baer F, Flachskampf F, Kamp O, Nienaber C, Nihoyannopoulos P, Pierard L, Steg G, Vanoverschelde JL, Van der Wouw P, Meland N, Marelli C, Lindvall K. NClOOlOO, a new echo contrast agent for the assessment of myocardial perfusion—safety and comparison with technetium-99m sestamibi singlephoton emission computed tomography in a randomized multicenter study. Clin Cardiol 1999 22(4) 273-82. [Pg.3546]

Wong M, Evans S, Rivory LP, Hoskins JM, Mann GJ, Farlow D et al (2005) Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer. Clin Pharmacol Ther 77 33 2... [Pg.582]

Mahmarian JJ, Shaw LJ, Filipchuk NG, et al. A multinational study to establish the value of early adenosine technetium-99m sestamibi myocardial perfusion imaging in identifying a low-risk group for early hospital discharge after acute myocardial infarction. J Am Coll Cardiol 2006 48(12) 2448-57. [Pg.79]

Technetium[ Tc] sestamibi injection Technetium[ Tc] succimer injection Technetium[ Tc] sulfur colloid Injection... [Pg.74]

Borges-Neto S, Coleman RE, Jones RH (1990) Perfusion and function at rest and treadmill exercise using technetium-99m-sestamibi comparison of one- and two-day protocols in normal volunteers. J Nucl Med 31 1128-1132... [Pg.243]

Bristol-Myers Squibb (2001) Product Information. Cardiolite Kit for the preparation of technetium Tc-99m sestamibi for injection. Bristol-Myers Squibb Medical Imaging, Billerica, Mass. [Pg.243]

Council of Europe (2005) Technetium [ " Tc] sestamibi injection solution, European pharmacopeia monograph 1926. Maisonneuve, Sainte-Ruffine... [Pg.244]

Hesse B, Tagli K, Cuocolo A et al (2005) EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur J Nucl Med Mol Imaging 32 855-897 Hung JC, Wilson ME, Brown ML, Gibbons RJ (1991) Rapid preparation and quality control method for technetium-99m-2-methoxy isobutyl isonitrile (technetium-99m-sestamibi). J Nucl Med... [Pg.244]

Wei JP, Burke GJ, Mansberger AR Jr (1992) Prospective evaluation of the efficacy of technetium-99m-sestamibi and iodine-123 radionuclide imaging of abnormal parathyroid glands. Surgery 112 1111-1117... [Pg.244]

Melon. P.G.. Beanlands. R.S.. et al. (1992). Comparison of technetium-99m sestamibi and thallium-201 retention characteristics in canine myocardium. J. Am. Coll. Cardiol.. 1277-1283. [Pg.524]

Several gamma-emitting compounds have been synthesized, vahdated, and characterized as sensitive probes for Pgp and MRPl functional activity. Most of these compounds are cationic and modestly hydrophobic similar to the chemotherapeutic agents in the MDR phenotype. The radiopharmaceutical hexakis(2-methoxy-isobutyl-isonitrile)technetium-99m commonly known as [ Tc]Sestamibi or [ Tc]MIBI (Cardiolite ) was the first imaging agent recognized as transport substrate of Pgp and the most widely used in clinical and pre-clinical studies for functional evaluation of MDR [53]. [Pg.607]

Utsunomiya K, Balhnger JR, Piquette-Miller M, Rauth AM, Tang W, Su Z-F et al. Comparison of the accumulation and efflux kinetics of technetium-99m sestamibi and technetium-99m tetrofosmin in an MRP-expressing tumour cell Une. Eur J Nucl Med 2000 27 1786-1792. [Pg.639]

Kostakoglu L, Elahi N, Kiratli P, Ruacan S, Sayek I, Baltati E et al. Clinical validation of the influence of P-glycoprotein and technetium-99m-sestamibi uptake in malignant tumors. J Nucl Med 1997 38 1003-1008. [Pg.640]

Del Vecchio S, Ciarmiello A, Potena MI, Carriero MV, Mainolfi C, Botti G et al. In vivo detection of multi drug-resistant (MDRl) phenotype by technetium-99m sestamibi scan in untreated breast cancer patients. Eur J Nucl Med 1991 24 150-159. [Pg.640]

Ciarmiello A, Del Vecchio S, Silvestro P, Potena MI, Carriero MV, Thomas R et al. Tumor clearance of technetium 99m-sestamibi as a predictor of response to neoadjuvant chemotherapy for locally advanced breast cancer. J Clin Oncol 1998 16 1677-1683. [Pg.640]

Here we will recall just two of the advances made in the field of radiopharmaceuticals over the last few years. One shining example of an organometallic pharmaceutical that has been successfully commercialized is technetium-99m sestamibi, a hexakis (aUcyhsocyanide) complex of Tc(I) 29 that has become the most important myocardial imaging agent. The success of this compound, known by its trade name Cardiohte , has inspired researchers to develop other Tc-based radiopharmaceuticals [193-197]. [Pg.26]

See other pages where Technetium sestamibi is mentioned: [Pg.1141]    [Pg.466]    [Pg.166]    [Pg.973]    [Pg.1141]    [Pg.466]    [Pg.166]    [Pg.973]    [Pg.294]    [Pg.295]    [Pg.17]    [Pg.33]    [Pg.1597]    [Pg.165]    [Pg.453]    [Pg.1093]    [Pg.466]    [Pg.494]    [Pg.74]    [Pg.142]    [Pg.237]    [Pg.244]    [Pg.244]    [Pg.244]    [Pg.2082]    [Pg.102]   
See also in sourсe #XX -- [ Pg.166 ]



SEARCH



Technetium

© 2024 chempedia.info