Myocardial perfusion imaging

Technetium-9 9m sestamibi is used in myocardial perfusion imaging for the evaluation of ischemic heart disease. It is prepared from a lyophilized kit containing tetrakis(2-methoxy isobutyl isonittile) copper(I) tetrafluoroborate stored under nitrogen. Upon reconstitution with up to 5.6 GBq (150 mCi) of 99mTc pertechnetate, the product is formed by boiling for 10 minutes. [Pg.483]

Stress myocardial perfusion imaging with the radionuclides technetium-99m sestamibi or thallium-201 allows for the identification of multivessel disease and assessment of myocardial viability. [Pg.68]

Fig. 4. Lipophilic-cationic( +1) myocardial perfusion imaging agents A) 99mTc-tetrofosmin R = -CH2CH,0CH,CH3 B), 9"Tc = sestamibi R=C=NCH,C (OCHJ (CH,), Q 99mTc-furifosmin R = -CH2CH2OCH2CH3...

Complex 65 (Cardiolite), 99mTc(I)-sestamibi, is used for myocardial perfusion imaging. It was designed on the basis that lipophilic cationic complexes behave as potassium mimics and are taken up by the myocardium (281). The sequential metabolism of the six methoxy groups of 65 to hydroxyl groups in the liver leads to formation of 99mTc complexes with greater hydrophilicity which are not retained in myocardial tissues (282). [Pg.230]

Indications for radionuclide imaging in these patients are detailed in current ACC/AHA guidelines [68] and ACCF/ASNC appropriateness criteria for SPECT myocardial perfusion imaging [69]. While a detailed discussion of these indications is beyond the purpose of this text, for patients with advanced... [Pg.21]

Kirkeeide RL, Gould KL, Parsel L. Assessment of coronary stenoses by myocardial perfusion imaging during... [Pg.32]

He ZX, Verani MS. Evaluation of myocardial viability by myocardial perfusion imaging should nitrates be used J Nucl Cardiol 1998 5 527-532... [Pg.33]

Brown KA. Prognostic value of myocardial perfusion imaging state of the art and new developments. J Nucl Cardiol 1996 3 516-537... [Pg.34]

Loghin C, Sdringola S, Gould KL. Common artifacts in PET myocardial perfusion images due to attenuation-emission misregistration clinical significance, causes, and solutions. J Nucl Med 2004 45 1029-1039... [Pg.36]

Mechanism of Action A cardiac agent that slows impulse formation in the SA node and conduction time through the AV node. Adenosine also acts as a diagnostic aid in myocardial perfusion imaging or stress echocardiography. Therapeutic Effect Depresses left ventricular function and restores normal sinus rhythm. [Pg.21]

Rubidium-82 myocardial perfusion images are used to study patients with myocardial ischemia or infarction. An example of this study is shown in Figure 8. Three patients with known myocardial infarction were imaged with Rb-82. Twenty millicuries of Rb-82 were administered in a 20 ml bolus in 20 sec. Data accumulated from 0-90 seconds post infusion show the blood pool as the radioactivity enters the right side of the heart, flows out to the lungs, and returns to the left side of the heart. Data accumulated from 90-300 seconds reflect uptake of Rb-82 in the myocardium as distributed by blood flow. These results by a non-invasive procedure correlated with the results of catheterized contrast x-ray studies (27,28). [Pg.115]

In numerous animal models, it has reportedly promoted angiogenesis, improved myocardial perfusion, and acutely improved endothelial vasodilatory function. In the present study, we report the impact of the administration of recombinant FGF-2 (rFGF-2) on stress and rest myocardial perfusion using gated SPECT myocardial perfusion imaging in a phase I trial in humans with advanced symptomatic coronary artery disease. [Pg.394]

Hexakis(2-methoxyisobutylisonitrile)technetium-99m (commonly known as [99mTc]Sestamibi) (20a), although originally developed as a radiopharmaceutical for myocardial perfusion imaging [59,60], was the first metal complex... [Pg.165]

Rb82 e+1 65 h Positron emission tomography for myocardial perfusion imaging... [Pg.575]

Heart Agents. Routine myocardial perfusion imaging in nuclear medicine started with ° T1 thallous chloride. While ° T1+ is efficiently perfused into the myocardium, the long half-life and imaging characteristic s are not optimal for nuclear medicine imaging and cationic Tc-based perfusion agents were desired. [Pg.5479]

In 18 children with aortic valve disease or Kawasaki disease, adenosine stress myocardial perfusion imaging was associated with the usual adverse effects, most commonly flushing and dyspnea (12). [Pg.36]

Exercise reduces both non-cardiac adverse effects and dysrhythmias in patients who are given adenosine for diagnostic purposes in myocardial perfusion imaging (SEDA-... [Pg.36]

The incidence of atrioventricular block has been reported in 600 consecutive patients who underwent stress myocardial perfusion imaging with adenosine (140 micrograms/kg/minute for 6 minutes), and of whom 43 had first-degree heart block before adenosine and 557 had a baseline PR interval less than 200 ms (Table 1) (31). The heart block in all cases was of short duration, was not associated with any specific symptoms, and in no case required specific treatment. The risk of atrioventricular block during adenosine infusion was not increased by the presence of other drugs that might have caused atrioventricular block (digitalis, beta-blockers, diltiazem, verapamil). [Pg.38]

Pennell DJ, Mavrogeni SI, Forbat SM, Karwatowski SP, Underwood SR. Adenosine combined with dynamic exercise for myocardial perfusion imaging. J Am Coll Cardiol 1995 25(6) 1300-9. [Pg.39]

Thomas GS, Prill NV, Majmundar H, Fabrizi RR, Thomas JJ, Hayashida C, Kothapalli S, Payne JL, Payne MM, Miyamoto Ml. Treadmill exercise during adenosine infusion is safe, results in fewer adverse reactions, and improves myocardial perfusion image quality. J Nucl Cardiol 2000 7(5) 439-46. [Pg.40]

Elliott MD, Holly TA, Leonard SM, Hendel RC. Impact of an abbreviated adenosine protocol incorporating adjunctive treadmill exercise on adverse effects and image quality in patients undergoing stress myocardial perfusion imaging. J Nucl Cardiol 2000 7(6) 584-9. [Pg.40]

Indications Radionuclide myocardial perfusion imaging Category Adenosine A2A receptor agonist Diagnostic aid Half-life Immediate 30 minutes Terminal 2 hours... [Pg.501]

Indications For diagnostic use in myocardial perfusion imaging Category Radioactive element [Tl]... [Pg.565]

Sabharwal NK, Lahiri A. Role of myocardial perfusion imaging for risk stratification in suspected or known coronary artery disease. Heart 2003 89 1291-1297. [Pg.169]

Rb is approved by the FDA for myocardial perfusion imaging to delineate ischemia from infarction. [Pg.139]

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