Tandem time of flight

R. J. Cotter, W. Griffith, and C. Jelinek. Tandem Time-of-Flight (TOF/TOF) Mass Spectrometry and the Curved-Field Reflectron. J. Chromatogr., B855(2007) 2-13. 

Cornish, T.J. Cotter, R.J. Collision-Induced Dissociation in a Tandem Time-of-Flight Mass Spectrometer With Two... 

Vestal, M. L. Campbell, J. M. Tandem time-of-flight mass spectrometry. Methods Enzymol. 2005, 402, 79-108. 

Sundstrom, I., Hedeland, M., Bondesson, U., and Andren, P. E. (2002). Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry. J. Mass Spectrom. 37 414-420. 

W. Wuhrer, C. H. Hokke, and A. M. Deelder, Glycopeptide analysis by matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry reveals novel features of horseradish peroxidase glycosylation, Rapid Commun. Mass Spectrom., 18 (2004) 1741-1748. 

Macht, M., Asperger, A., and Deininger, S. O. (2004) Comparison of laser-induced dissociation and high-energy collision-induced dissociation using matrix-assisted laser desorption/ionization tandem time-of-flight (MALDI-TOE/TOF) for peptide and protein identification. Rapid Commun. Mass Spectrom. 18, 2093-2105. 

Conrotto, R Heilman, U. Lys Tag An easy and robust chemical modification for improved de novo sequencing with a matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometer. Rapid Commun. Mass. Spectrom. 2008, 22,... 

J0rgensen, T.J., Bache, N., Roepstorff, P., et al. (2005) CoUisional activation by MALDI tandem time-of-flight mass spectrometry induces intrrunolecular migration of amide hydrogens in protonated peptides. 

R. J. Cotter, B. D. Gardner, S. Ilchenko, and R. D. English, Tandem time-of-flight mass spectrometry with a curved field refiectron. Anal. Chem. 76, 1976-1981 (2004). 

Figure 5 Design and iayout of the tandem time-of-flight mass spectrometer, coupled to a MALDI source.

Figure 2.6 MALDI tandem time-of-flight mass spectrometry.

This chapter describes a step-by-step protocol for top-down proteomic identification of protein biomarkers of bacterial food-borne pathogens using matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry (MALDI-TOF-TOF-MS/MS) and web-based software developed at the Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture (USDA). 

Fagerquist, C.K., WiUiams, K.E., Bates, A.H. (2007) Identification of foodborne bacteria by high energy collision-induced dissociation of their protein biomarkers by MALDI tandem-time-of-flight mass spectrometry. In Proceedings of the 55th American Society of Mass Spectrometry Conference, June 3-7, Indianapolis, IN [DVD MPT-327 from ASMS]. 

The frozen sections were thaw-mounted on indium-tin-oxide (ITO)-coated glass slides (Bruker Daltonics) and ITO-coated sheets (Tobi Co., Ltd., Kyoto, Japan). The slides were used for tandem time-of-flight (TOF/TOF) measurements and the sheets were used for quadrupole ion trap (QIT)-TOF measurements. 

Alley, W. R., Jr., Mechref, Y., Klouckova, L, Novotny, M. V. (2007) Improved collision-induced dissociation analysis of peptides by matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry through 3-sulfobenzoic acid succinimidyl ester labeling. / Proteome Res, 6, 124-132. 

Ilchenko S, Cotter RJ. Collision energetics in a tandem time-of-flight (TOF/TOF) mass spectrometer with a curved-field reflectron. Int J Mass Spec 2007 265(2—3) 372—81. 

The introduction of MALDI as an effective ionization method for peptides, proteins, and other biopolymers has provided considerable motivation for the development of tandem time-of-flight instruments that would compete favorably with electrospray ionization, which enjoys easy compatability with tandem, triple quadru-pole mass spectrometers. Tandem TOF instruments would be considerably less expensive alternatives for routine sequencing of peptides obtained from enzymatic digests or from other biological mixtures. 

FIGURE 9.16 Tandem time-of-flight mass spectrometer, using photodissociation with an excimer laser (Reprinted with permission from reference 9). 

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