High-energy collision induced dissociation

Lewandrowski, U. Resemann, A. Sickmann, A. Laser-induced dissociation/high-energy collision-induced dissociation fragmentation using MALDI-TOF/TOF-MS instrumentation for the analysis of neutral and acidic oligosaccharides. Anal. Chem. 2005, 77, 3274-3283. 

Scans based on resonant ejection may either be carried out in a forward, i.e., from low to high mass, or a reverse manner. This allows for the selective storage of ions of a certain m/z value by elimination of ions below and above that m/z value from the trap. Thus, it can serve for precursor ion selection in tandem MS experminents. [156,158] Axial excitation can also be used to cause collision-induced dissociation (CID) of the ions as a result of numerous low-energy collisions with the helium buffer gas that is present in the trap in order to dampen the ion motion. [150,156] A substantial increase of the mass range is realized by reduction of both the RF frequency of the modulation voltage and the physical size of theQIT. [154,159,160]... 

Nizigiyimana, L. Rajan, P.K. Haemers, A. Claeys, M. Derrick, P.J. Mechanistic Aspects of High-Energy Collision-Induced Dissociation Proximate to the Charge in Saturated Fatty Acid n-Butyl Esters Ca-tionized With Lithium. Evidence for Hydrogen Radical Removal. Rapid Commun. Mass Spectrom. 1997, 11, 1808-1812. 

Griffiths WJ, Alvelius G, Liu S, Sjovall J (2004) High-energy collision-induced dissociation of oxosteroids derivatised to Girard hydrazones. Eur J Mass Spectrom (Chichester, Eng) 10 63-88... 

Velocity and angular distribution measurements of the product ions from collision-induced dissociation have provided additional information concerning the mechanisms of these processes and the nature of the reactant and product states involved.380 62,208 213"218 The experimental results obtained at relatively high incident-ion energies are generally... 

The collision-induced dissociations of several triatomic and polyatomic ions have been studied and the participation of excited states such as COS+(/42II) has been detected.224 Such experiments225 227 have also provided insight into the structures of isomeric ions involved. All these studies were conducted with incident ions of relatively high (kiloelectron volt) kinetic energies and also entailed determination of the kinetic energies of the product ions and/or the fragmentation patterns. 

Collision-induced dissociation FAB MS/MS trace of the (M + Na)+ of an oligosaccharide, measured at high energy. It allows one to determine the positional isomers of all its glycosidic bonds. Reproduced (modified) from Lemoine J., Fournet B., Despeyroux D., Jennings R., Rosenberg R. and de Hoffmann E., J., Am.Soc. Mass Spectrom., 4, 197, 1993, with permission. 

Collision-induced dissociation FAB/MS/MS trace of octadecanoic acid acquired in the negative ion mode at high energy. Reproduced (modified) from Jensen N.J., Tomer K.B. and Gross M.L., Anal. Chem., 57, 2018, 1985, with permission. 

Yates, J.R., Eng, J.K., Clauser, K.R. and Burlingame, A.L. (1996) Search of sequence databases with uninterpreted high-energy collision-induced dissociation spectra of peptides. J. Am. Soc. Mass Spectrom., 7 (11) 1089-98. 

Nizigiyimana, L., Van Den Heuvel, H. and Claeys, M. (1997) Comparison of low- and high-energy collision-induced dissociation tandem mass spectrometry in the analysis of ricinoleic and ricinelaidic acid. J. Mass Spectrom., 32 (3), 277-86. 

Gas-phase acid-base studies are usually performed by using one of the following techniques high-pressure mass spectrometry (HPMS), chemical ionization mass spectroscopy (CIMS) with mass-analysed ion kinetic energy spectroscopy/collision induced dissociation (MIKES/CID), flowing afterglow (FA) or ion cyclotron resonance (ICR) spectrometry. For a brief description of all methods, Reference 8 should be consulted. 

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