Tablet antacid

The analytical measurement of elemental concentrations is important for the analysis of the major and minor constituents of pharmaceutical products. The use of atomic spectroscopy in this regard has been the subject of several reviews (2,3,35,36). Metals are major constituents of several pharmaceuticals such as dialysis solutions, lithium carbonate tablets, antacids, and multivitamin-mineral tablets. For these substances, spectroscopic analysis is an important tool. It is indispensable for the determination of trace-metal impurities in pharmaceutical products and the qualitative and quantitative analysis of metals, essential and toxic, in biological fluids and tissues (37). Beyond this, several drugs which do... 

USP-grade anhydrous magnesium carbonate is used as a flavor impression intensification vehicle in the processed food industry (see Flavors and spices). Basic magnesium carbonates are used as free flowing agents in the manufacture of table salt, as a hulking agent in powder and tablet pharmaceutical formulations, as an antacid, and in a variety of personal care products (see Pharmaceuticals). 

Stomach acid is approximately 0.020 M HC1. What volume of this add is neutralized by an antacid tablet that weighs 330 mg and contains 41.0% Mg(OH)2, 36.2% NaHCOj, and 22.8% NaCl The reactions involved are... 

Capsules or tablets should be taken with water unless the primary health care provider or pharmacist directs otherwise (eg, take with food, milk, or an antacid). Some liquids, such as coffee, tea, fruit juice, and carbonated beverages, may interfere with the action of certain drags. 

KETOCONAZOLE This drug is given with food to minimize gastrointestinal irritation. Tablets may be crushed. Ketoconazole is absorbed best in an acid environment. Do not administer antacids, anticholinergics, or histamine blockers until at least 2 hours after ketoconazole is given. 

Bisacodyl (Dulcolax)—Do not chew tiie tablets or take them within 1 hour of taking antacids or milk. 

In a series of papers, personnel from Novartis and the University of Basel in Switzerland have highlighted the pros and cons of neural networks for immediate release tablets [37-40]. In other studies neural networks have been found useful in modeling tablet formulations of antacids [41], plant extracts [42], theophylline [43], and diltiazem [44]. In a recent paper Lindberg and Colbourn [45] have used neural networks, genetic algorithms, and neurofuzzy to successfully analyze historical data from three different immediate-release tablet formulations. 

C An antacid tablet produces bubbles of gas when placed in water. 

Obtain five effervescent antacid tablets. Break each tablet into four equal pieces. One of these pieces will be used for each trial. 

Drop a piece of the antacid tablet into the water. Immediately start the timer. Stir the contents of the test tube throughout the reaction. 

Antacid/alginic acid (Gaviscon) 2 tablets or 1 5 mL after meals and at bedtime AND/OR C. Patient-directed therapy Over-the-counter H2RAs (each taken up to twice daily) - Cimetidine 200 mg - Lamotidine 1 0 mg - Nizatidine 75 mg - Ranitidine 75 mg OR Over-the-counter PPI (taken once daily) - Omeprazole 20 mg agent. 

Chewable Tablets. It has already been noted that most elderly patients experience a decrease in their ability to chew efficiently [125,137,138,143]. Therefore, by virtue of their design, chewable tablets are not often recommended for use by elderly patients (particularly those who are edentulous) 155-163,164], Most chewable formulations also rely on an adequate amount of chewing action to obtain full release of their ingredients (e.g., chewing promotes the foaming action provided by some chewable antacid products). So, aside from being difficult form the elderly patient to use, full benefit of a chewable dosage form may not be achieved by these patients. Additionally, the use of chewable tablets by denture wearers may cause local irritation in the oral cavity [155]. 

The familiar fizzing action that occurs as an antacid tablet dissolves in water is the result of a chemical reaction involving the ingredients in the tablet. 

Each Alka-Seltzer tablet contains 1916 mg of sodium bicarbonate, 1000 mg of citric acid (Fig. 9.1.2), and 325 mg of aspirin or acetylsalicylic acid (Fig. 9.1.3). Bromo Seltzer also contains sodium bicarbonate and citric acid as well as acetaminophen (Fig. 9.1.4). Several equilibria describe the action of bicarbonate-based antacid tablets. First of all, sodium bicarbonate dissolves completely in aqueous solution to generate sodium ions and bicarbonate ions ... 

Calculate the mmoles of NaAl(0H)2C03 in one antacid tablet. 

Calculate the mmoles of HC1 that can be neutralized by the antacid tablet. 

The number of mmoles of HC1 in your stomach is roughly nine times greater than the number of mmoles of HC1 that can be neutralized by a single antacid tablet. However, about 2 tablets are sufficient to neutralize the excess HC1 in the stomach by reducing its concentration down to the normal 8.0 x 10-2 M level. 

Antacids have a short duration, which necessitates frequent administration throughout the day to provide continuous acid neutralization. Typical doses are two tablets or 1 tablespoonful four times daily (after meals and at bedtime). Nighttime acid suppression cannot be maintained with bedtime doses of antacids. 

Intermittent, mild heartburn Lifestyle modifications plus patient-directed therapy Antacids Maalox or Mylanta 30 mL as needed or after meals and at bedtime Gaviscon 2 tabs after meals and at bedtime Calcium carbonate 500 mg, 2-4 tablets as needed and/or Nonprescription 11 receptor antagonists (taken up to twice daily) Cimetidine 200 mg Famotidine 10 mg Nizatidine 75 mg Ranitidine 75 mg or... 

TXRF was used to characterize high-viscosity polymer dispersions [83], with special attention being paid to the different drying techniques and their effect on the uniformity of the deposited films. TXRF was also used as a means to classify different polymers on the basis of their incoherently scattered peaks [84], Dispersive XRF has been used to assess the level of aluminum in antacid tablets [85]. 

It may seem strange that we would ever want to perform an experiment of this kind. First of all it would be used in the event of a slow reaction taking place in the reaction flask. Perhaps the sample is not dissolved completely, and addition of the titrant causes dissolution to take place over a period of minutes or hours. Adding an excess of the titrant and back-titrating it later would seem an appropriate course of action in a case of this kind. An example would be the determination of the calcium carbonate in an antacid tablet (Experiment 13). 

What is the percent of CaC03 in an antacid given that a tablet that weighed 1.3198 g reacted with 50.00 mL of 0.4486 N HC1 that subsequently required 3.72 mL of 0.1277 N NaOH for back titration Also report the milligrams of CaC03 in the tablet. 

In this experiment the neutralizing power of various antacids will be determined. Antacids contain basic compounds that will neutralize stomach acid (stomach acid is HC1). The amount of base in the antacid tablets will be determined by an acid-base titration. It is a back titration method. This method is used because most antacids produce carbon dioxide gas, which can interfere with the titration. By initially adding an excess of acid, one can drive off the C02 by boiling the solution before titrating the excess acid. There are many brands of commercial antacids with various ingredients. A few of the common ones are listed below ... 

Record the name of the antacid you are testing. Describe the bottle include price, net weight, number of tablets, active ingredients, and other information from the label. 

Weigh three individual antacid tablets (of the same brand) to the nearest 0.001 g and place them in separate 250-mL Erlenmeyer flasks. Crush the tablets thoroughly with a glass stirring rod. 

Calculate the average moles of acid neutralized per tablet, the average moles of acid neutralized per gram of tablet, and the average percent base (calculated as CaC03) in the antacid. Compare your results with others in the class for the different brands analyzed. 

Why is a back titration useful in the analysis of an antacid tablet containing calcium carbonate as the active ingredient ... 

If your iid is not expioding off, it is probabiy because the iid on the canister is not tight enough.Try using a film canister that has a iid that fits inside, not one that fits around the outside of the canister. You can also try using another container that has a lid that fits snugly but doesn t screw on, such as the lid on some antacid tablets. 

Swallow tablets whole do not chew, crush, or dissolve. Tablets may be taken with meals to minimize Gl effects. Avoid coadministration with magnesium-containing antacids. 

Tablets 500, 600, 650, 1,000, Various, Maalox Antacid Caplets 1,250 mg (ofc) (Rhone-Poulenc Rorer)...

Antacid - 2 capsules or tablets or 10 mL of regular suspension (in water or fruit juice) as often as every 2 hours, up to 12 times daily. 

---