Antacids Maalox

Intermittent, mild heartburn Lifestyle modifications plus patient-directed therapy Antacids Maalox or Mylanta 30 mL as needed or after meals and at bedtime Gaviscon 2 tabs after meals and at bedtime Calcium carbonate 500 mg, 2-4 tablets as needed and/or Nonprescription 11 receptor antagonists (taken up to twice daily) Cimetidine 200 mg Famotidine 10 mg Nizatidine 75 mg Ranitidine 75 mg or... 

The popular antacid Maalox is named for the combination of three ions in its formula. The first of these ions is magnesium. What are the other two ions ... 

E. Aluminum/magnesium hydroxide combination antacid (Maalox )... 

Magnesium containing drugs such as antacids (Maalox) and sorbitol. Sorbitol is used as filler for... 

The charge nurse notices that the primary nurse is preparing to administer the antacid Maalox to the client receiving his routine morning medications. Which action should the charge nurse take first ... 

The nurse is preparing to administer 15 mL of the antacid Maalox from a bottle to a client. Which intervention should the nurse implement ... 

In 24 healthy subjects an aluminium/magnesium hydroxide antacid (Maalox) had no effect on the rate or extent of absorption of a single 25-mg dose of dexketoprofen, although the maximum level was slightly (13%) lower. ... 

A study with cefaclor AF (a formulation with a slow rate of release) found that an aluminium/magnesium hydroxide antacid (Maalox) given one hour after the cefaclor AF to fed subjects reduced the AUC by 18%. This reduction is small and unlikely to be clinically important. 

An aluminium/magnesium hydroxide antacid (Maalox) given as 8 doses of 10 niL on day one and 2 doses on day 2, had only small and therapeu-tieally unimportant effeets on the pharmacokinetics of cefalexin 1 g. ... 

An aluminium/magnesium hydroxide antacid (Maalox) and AlkaSelt-zer (aspirin, calcium phosphate, citric acid and sodium bicarbonate) do not significantly affect the absorption of cefixime, ... 

A study in 10 healthy subjects found that 10 mL of an aluminium/magnesium hydroxide antacid (Maalox) reduced the bioavailability of cefpodoxime proxetil by about 40%. This was considered to be due to reduced dissolution at increased gastric pH values. These results confirm the findings of a previous study with sodium bicarbonate and aluminium hydroxide. It has been recommended that cefpodoxime is given at least 2 hours after antacids. ... 

An aluminium/magnesium hydroxide antacid Maalox TO) reduced the bioavailability of gabapentin 400 mg by about 20% when given either at the same time or 2 hours after gabapentin. When the antacid was given 2 hours before the gabapentin, the bioavailability was reduced by about 10%. These small changes are unlikely to be of clinical importance. How-... 

The manufacturer notes that when a single 120-mg dose of fexofenadine was given within 15 minutes of an aluminium/magnesium hydroxide antacid (Maalox), the fexofenadine AUC was decreased by 41% and the maximum level was decreased by 43%. Although the effect of these reductions on possible efficacy has not been assessed, the manufacturer recommends that it is advisable to leave 2 hours between the administration of fexofenadine and antacids containing aluminium and magnesium hydroxide. ... 

A study in 12 patients found that 20 mL of an aluminium/magnesium hydroxide antacid (Maalox) caused a small increase in the plasma levels of a single 1250-mg/m oral dose of capecitabine and one metabolite (5 -DFCR) but it had no effect on the other 3 major metabolites (5 DFUR, 5-FU and FBAL). There would therefore seem to be no reason for taking special precautions if capecitabine and an antacid of this type are used concurrently. 

In a crossover study in healthy subjects the AUC of amprenavir (derived from a single 1.4-g dose of fosamprenavir) was decreased by 18% and the maximum plasma level by 35%, but the minimum level was not significantly altered by the concurrent use of 30 mL of an aluminium/magnesi-um hydroxide antacid (Maalox TC). ... 

In a single-dose study, 12 healthy subjects were, on separate occasions, given 20 mg of rabeprazole with, without, and 1-hour after a dose of alu-minium/magnesium hydroxide antacid (Maalox).The antacid had no effect on the pharmacokinetics of rabeprazole, so no speeial precautions would seem necessary on concurrent use. 

An aluminium/magnesiium hydroxide antacid Maalox) causesi a moderate reduction in the bioavailability of atorvastatin, pravastatin, and rosuvastatin, but the lipid-lowering efficacy of atorvastatin and pravastatin is not affected. 

In a two-way crossover study a single 20-mg dose of vardenafil was given to 12 healthy subjects with 10 mL of an aluminium/magnesium hydroxide antacid (Maalox 70). The bioavailability of vardenafil was not significantly altered by the antacid, therefore no additional precautions are needed if these drugs are used together. ... 

Rohde G, Wensing G, Sachse R. The pharmacokinetics of vardenafil, a new selective PDE5 inhibitor, are not affected by the antacid, Maalox 70. Pharmacotherapy (2001) 21, 1254. 

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