T-cells subsets

To classify cell lines, e.g. the T-cell subsets, and thence to separate these cell subpopulations. 

CD lb Known to be present on thymocytes and dendritic cells CDlc Isoform c also known as non-classical MHC class I-like surface antigen present on thymocytes CD2 Defines T cells involved in antigen non-specific cell activation CD3 Also known as T cell receptor-associated surface glycoprotein on T cells CD4 Defines MHC class Il-restricted T cell subsets... 

CDS Defines MHC class I-restricted T cell subset present on NK cells CDIO Known to be common acute leukaemia antigen CDlla Known to be zn a chain of LFA-1 (leucocyte function antigen-1) present on several types of leucocyte and which mediates adhesion CDllc Known to be z complement receptor 4 a chain. 

Swain SL. Regulation of the development of helper T cell subsets. Immunol Res 1991 10 177-182. 

Kim CH, Kunkel EJ, Boisvert J, et al. Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. J Clin Invest 2001 107 595-601. 

Kleinewietfeld M, Puentes F, Borsellino G, Battistini L, Rotzschke O, Falk K. CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset. Blood 2005 105 2877-2886. 

Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets function, generation, and maintenance. Annu Rev Immunol 2004 22 745-763. 

Lanzavecchia A, Sallusto F. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 2005 17(3) 326-332. 

Purine nucleoside phosphorylase (PNP) deficiency engenders a combined immunodeficiency and neurologic abnormalities and is usually fatal in childhood (G4). Patients with PNP deficiency have profound lymphopenia and a small thymus with poorly formed Hassall corpuscles. Lymphocyte enumeration shows markedly decreased numbers of T cells and T-cell subsets, with normal percentages of B cells. Point mutations and a splicing mutation have been identified in some PNP-deficient patients (H4). 

Velupillai, P. and Ham, D.A. (1994) Oligosaccharide-specific induction of interleukin-10 production by B220+ cells from schistosome-infected mice - a mechanism for regulation of CD4+ T-cell subsets. Proceedings of the National Academy of Sciences USA 91, 18—22. 

Pond, L., Wassom, D.L. and Hayes, C.E. (1989) Evidence for differential induction of helper T cell subsets during Trichinella spiralis infection. Journal ofImmunology 143, 4232-4237. 

In vitro TGN1412 caused a profound, polyclonal T-cell proliferation of human peripheral blood mononuclear cells, including those from patients with BCLL. It also induced a profound activation and proliferation of T-cell subsets including CD4+ and CD8+ T cells, naive and memory T cells, and regulatory T cells. TGN1412 was shown to induce a transient, well tolerated expansion of T cells in nonhuman primates treated with TGN1412 and efficacy was demonstrated in a rhesus monkey collagen-induced arthritis model. 

McCabe Jr., M.J. and Lawrence, D. A., Lead, a major environmental pollutant, is immunomodulatory by its differential effects on CD4+ T cell subsets, Toxicol. Appl. Pharmacol. Ill, 13, 1991. 

TCDD (reviewed in13). However, despite considerable effort, direct effects of TCDD on purified T cells in vitro have not been consistently demonstrated, and direct effects on T cells in vivo are difficult to prove. This issue was recently resolved by studies that compared the effects of TCDD on the graft versus host (GVH) response of T cells obtained from AhR+,+ and AhR C57B1/6 (B6) mice.66 Results showed that the CTL response of grafted AhR- - T cells was resistant to TCDD-induced suppression, while under the same conditions, the CTL response of AhR+,+ T cells was suppressed by > 90%. Furthermore, when CD4+ and CD8+ T cell subsets were isolated from AhR+,+ and AhR- - mice and then recombined prior to grafting, full suppression of the CTL was dependent on AhR expression in both T cell subsets. These results provide the first evidence for the requisite role of the AhR in T cells for TCDD-mediated suppression of T cell responses. Induction of CYP1A1 in purified T cells exposed to TCDD in vitro validates the presence of a functional AhR.6-7... 

Prell, R., Oughton, J., and Kerkvliet, N.I., Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on anti-CD3-induced changes in T cell subsets and cytokine production, Int. J. Immunopharmacol., 17, 951, 1995. 

Groux, H. et al., A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis, Nature 389,737-742, 1997. 

Tsuji, T., et al. Efficient induction of immunoglobulin production in neonatal naive B cells by memory CD4+ T cell subset expressing homing receptor L-selectin, J. Immunol., 152, 4417, 1994. 

Cells other than T lymphocytes also appear to be involved in tolerance induction. Depletion of macrophages inhibited tolerance induction and transfer studies with non-T cell fractions from tolerant animals was shown to confer tolerance to naive animals [29] Thus, tolerance induction by low doses of D-penicillamine appears to have a complex mechanism that includes various T cell subsets as well as non-T cells, that may be antigen presenting cells. 

Tabo, J.D. and Paul, W.E. (1973). Functional heterogeneity of murine lymphoid cells. III. Differential responsiveness of T cells to phytohemagglutinin and concanavalin A for T cell subsets. J. Immunol. 110 362-369. 

The newly discovered T-cell subsets are an important step regarding our attempts to translate... 

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