T cell antigen receptor signaling

Qian, D. and Weiss, A. T cell antigen receptor signal transduction (1997) Curr. Op. Cell Biol. 9, 205- 212... 

A. Weiss. T cell antigen receptor signal transduction a tale of tails and cytoplasmic protein-tyrosine kmases. CeU, 73 (2), 209-212, 1993. 

Yamasaki S, Tachibana M, Shinohara N, Iwashima M Lck-independent triggering of T-cell antigen receptor signal transduction by staphylococcal enterotoxins. J Biol Chem 1997 272 14787-14791. 

Mueller, D. L., Jenkins, M. K., and Schwartz, R. H. (1989). Clonal expansion ver.sus functional clonal inactivation A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7, 445-480. 

CD3 complex of delta, epsilon, gamma, zeta and eta chains of integral membrane glycoproteins that associates with T cell antigen receptor (TCR), and is required for TCR cell surface expression and signal transduction. CDS is a universally expressed by T cells. Member of immunoglobulin superfamily. 

The T cell antigen receptor contains a minimum of 8 polypeptides and may be divided into two functional complexes, in which one mediates ligand binding and the other performs the signal transduction. Antigen binding takes place via the Ti-a and / subunits, which only have very short cytoplasmic structural portions and are not di-... 

Samelson LE Signal transduction mediated by the T cell antigen receptor the role of adapterpro-teins. Annu Rev Immunol 2002 20 371-394. 

Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, Samelson LE 2000 Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. J Biol Chem 275 23355-23361... 

Janes, P. W. Ley, S. L. Magee, A. I. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol. 1999,147,441-461. 

Sugawara H, Kurosaki M, Takata M, Kurosaki T 1997 Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J 16 3078-3088... 

Wang, J., Koizumi, T., and Watanabe, T., 1996, Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J.Exp. Med. 184 831-838. 

Yankee, T. M., L. M. Keshvara, S. Sawasdikosol, M. L. Harrison, and R. L. Geahlen. Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain. J Immunol. 163 5827-35.1999. 

The T and B cell antigen receptors are generally composed of several subunits, whereby the frmctions of ligand binding and conduction of the signal are localized on separate subrmits (review Weiss and Littman, 1994 Wilson and Garcia, 1997). 

Intracellular Signal Molecules of the T and B Cell Antigen Receptors... 

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