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System laboratory-based

Immunosensors promise to become principal players ia chemical, diagnostic, and environmental analyses by the latter 1990s. Given the practical limits of immunosensors (low ppb or ng/mL to mid-pptr or pg/mL) and their portabiUty, the primary appHcation is expected to be as rapid screening devices ia noncentralized clinical laboratories, ia iatensive care faciUties, and as bedside monitors, ia physicians offices, and ia environmental and iadustrial settings (49—52). Industrial appHcations for immunosensors will also include use as the basis for automated on-line or flow-injection analysis systems to analyze and control pharmaceutical, food, and chemical processing lines (53). Immunosensors are not expected to replace laboratory-based immunoassays, but to open up new appHcations for immunoassay-based technology. [Pg.30]

As has already been mentioned in Chapter 2, ISO 9001, Management Systems - Requirements , is increasingly being adopted by laboratories to cover the aspects of their business that are not laboratory based. This is because this Standard is more about controlling the process and service enhancement rather than technical issues. It requires continuous improvement, demonstrating that quality is not a static process. The requirements for such matters as documentation, document control, purchasing and management responsibilities are much the... [Pg.228]

FDA device regulation is focused on the device and the device manufacturer. CLIA, on the other hand, focuses on laboratory quality, including the quality of the laboratory test results provided by the devices used, whether developed in-house or as a test kit in commercial distribution to multiple laboratories. The programs differ substantially in approaches and in data requirements. FDA requires unique submissions for each test under its purview, evaluates both performance and labeling, and requires demonstration of analytical validity and clinical validity as appropriate. CLIA inspects laboratories using a system approach based on key probes of the operating system. CLIA requires a demonstration of analytical performance and quality control but does not require a showing of either clinical validity or clinical utility. [Pg.111]

Treatment of wood with multi-component systems is likely to result in separation of the components when large wood samples are treated. This has been likened to the action of a chromatography column (Schneider, 1995). This is a significant problem that is often only encountered during scale-up of laboratory-based studies, where satisfactory results were previously obtained on small wood samples. Similarly, treatment of large wood samples can often lead to considerable variability in results due to inhomogeneous distribution, which again may not be evident with small samples treated under laboratory conditions. [Pg.150]

For laboratory-based systems the instrument function given by the effect of the beam conditioner must now be introduced. In Chapter 2 we discussed beam conditioners in detail and showed that they may be characterised in terms of an intensity which is a function of both divergence and wavelength. [Pg.118]

The system is based on an XP Zymate laboratory robot controlled with a 10 slot System V controller using software version XP VI.S2. The system incorporates commerdaUy available hardware, as well as custom hardware. A schematic diagram of the system is shown in Fig. 6.11. The robotic arm and the peripheral laboratory stations that the robotic arm interacts with to perform the appHcation are positioned in a circular configuration. The GC/MS is located adjacent to the bench top, such that the injection valve is close to the sipper station. Peripheral items of hardware with which the robotic arm does not directly interact with are outside the working envelope. [Pg.189]

Since the introduction of the first fully automated laboratory-based mercury analysers in 1989, a number of other systems have been introduced. Around 20 different systems are available with varying levels of performance, and many claim to measure mercury at low levels. The analyst can therefore be forgiven if the determination of mercury is considered a trivial problem. Despite the various claims, the determination of low levels of mercury... [Pg.219]

EPA. 1982f Test method - Base/neutrals and acids. Method-625. In Method for determination of organic compounds in drinking water. Cincinnati, OH U.S. Environmental Protection Agency, Environmental Monitoring Systems Laboratory. EPA/600/7-82/039. [Pg.244]

The demonstration that ultrafast X-ray investigations can be carried out with laboratory-based equipment will, hopefully, inspire others to build and apply such ultrafast systems themselves. (From Rose-Petruck, 2000)... [Pg.499]

System validation has always focused on the integrity of data once they are entered into a system, but if a research scientist misenters a data point or a robotic system misaligns a test tube, data that meet aU validation tests but are erroneous or misassigned can corrupt the end result. In effect, if your finger slipped and you typed in a 3 when you meant a 2 your computer wdl still add properly, but the answer you receive will be incorrect—GIGO the ultimate accuracy of laboratory systems is based in part on the accuracy of the data that are entered. [Pg.229]

T0821 U.S. ERA and IT Corporation, Debris Washing System T0822 U.S. EPA National Risk Management Research Laboratory, Base-Catalyzed Decomposition... [Pg.96]

The chemical analytical data on which Table I and Figures 2-5 are based were determined by the Analytical Chemistry Section of the Illinois State Geological Survey. The Survey research reported is sponsored, in part, by Grant No. R-800059 and Contract No. 68-02-0246 from the U. S. Environmental Protection Agency, Demonstration Projects Branch, Control Systems Laboratory, Research Triangle Park, N. C. [Pg.26]

Sampling with fiber optic sensors can be continuous if needed otherwise they can be operated discontinuously, with a lower duty cycle. These sensors could be used for laboratory-based or in situ applications. The cost of instrumentation for fiber optic systems should be 25,000 to 50,000. Sensors would need to be replaced periodically (several weeks to many months), depending upon their design. Sensors using fiber optic probes will be available within 5 years for some applications and within 10 years for some others. Sensors for pH, C02, and 02 are in development now new sensors should be capable of measuring from high concentrations down to 1 part per million for ions and organic materials. Basic research is still required for specific applications. [Pg.64]

Four applications of laboratory-based performance impairment test systems are described. These systems have been chosen to be presented for two reasons. First, they provide examples of the use of test systems for the measurement of performance impairment in commercial settings. Second, some information regarding the reliability and validity of these systems is available. [Pg.119]

Testing for phosphonates in the field remains a thankless task, even after 20 years or more of the availability of various methods. All available field methods are notoriously subject to interference from contaminants in the water or are inherently inaccurate. [This is not the case with American Society for Testing and Materials (ASTM) test methods and other laboratory-based test methods.] New technologies will no doubt arise, but methods such as the various tracing and polymer tagging systems may eventually prove to be superior. [Pg.373]


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See also in sourсe #XX -- [ Pg.112 ]




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