Synthesis molecularly imprinted polymers

Gel materials are utilized in a variety of technological appUcations and are currently investigated for advanced exploitations such as the formulation of intelligent gels and the synthesis of molecularly imprinted polymers. 

Synthesis and Characterisation of Molecularly Imprinted Polymer Nanoparticles for Streptomycin for Use as Solid Phase Extraction Materials... 

Drrion B, Cobb Z, Schillinger E, Andersson LI, Sellergren B. Water-compatible molecularly imprinted polymers obtained via high-throughput synthesis and experimental design. J Am Chem Soc 2003 125 15101-15109. 

W. M. Mullett, P. Martin, and J. Pawliszyn, In-Tube Molecularly Imprinted Polymer Solid-Phase Microextraction for the Selective Determination of Propranolol, Anal. Chem. 2001, 73, 2383 N. Masque, R. M. Marce, F. Borrull, P. A. G. Cormack, and D. C. Sherrington, Synthesis and Evaluation of a Molecularly Imprinted Polymer for Solid-Phase Extraction of 4-Nitrophenol from Environmental Water, Anal. Chem. 2000, 72, 4122. 

MASQUE N, MARCE R M, BORULL F, CORMACK PAG and SHERRINGTON D C (2000), Synthesis and evaluation of a molecularly imprinted polymer for selective on-line solid-phase extraction of 4-nitrophenol from environmental water , Anal Chem, 72, 4122-4126. 

Covalent polymers can be imprinted with patterns from small guest molecules at the time of synthesis. These molecular Imprinted polymers (MIPs) are useful in sensing applications. 

A wide variety of polymeric membranes with different barrier properties is already available, many of them in various formats and with various dedicated specifications. The ongoing development in the field is very dynamic and focused on further increasing barrier selectivities (if possible at maximum transmembrane fluxes) and/ or improving membrane stability in order to broaden the applicability. This tailoring of membrane performance is done via various routes controlled macro-molecular synthesis (with a focus on functional polymeric architectures), development of advanced polymer blends or mixed-matrix materials, preparation of novel composite membranes and selective surface modification are the most important trends. Advanced functional polymer membranes such as stimuli-responsive [54] or molecularly imprinted polymer (MIP) membranes [55] are examples of the development of another dimension in that field. On that basis, it is expected that polymeric membranes will play a major role in process intensification in many different fields. 

Synthetic polymer spheres with the ability for molecular recognition represent a promising alternative to affinity binding matrices using biological molecules. This chapter describes various methods for the preparation of molecularly imprinted polymer spheres in the colloidal state. The synthesis, characterization, and performance of colloidal dispersions of molecularly imprinted polymer spheres and their application are discussed. 

Controlled Synthesis of Colloidal Molecularly Imprinted Polymers 128... 

In this chapter we describe various methods for preparing molecularly imprinted polymers (MIP) in a colloidal state. The resulting materials consist of submicron scale particles dispersed in a liquid acting as fully functional synthetic affinity receptors. The synthesis, characterization, and performance of colloidal molecularly imprinted polymers are described and applications with this new class of affinity receptors is discussed. 

Molecular imprinted polymers (MIPs) attracted significant attention in the last decade as chiral stationary phases targeted for the separation of selected compounds used as templates during the synthesis of packing material [88]. 

Molecularly imprinted polymers have come to be recognised as antibody mimics since Mosbach and co-workers demonstrated the use of imprinted polymers for the sorbent assay of drugs [1], Not only in applications, but also in preparation principle, imprinted polymers can be regarded as antibody mimics the synthesis proceeds in a tailor-made fashion and the resultant polymers show specific binding for a given guest molecule. Also, imprinted polymers have many characteristic features as synthetic antibody mimics that contrast with natural antibodies. 

SYNTHESIS OF ION-SELECTIVE MOLECULARLY IMPRINTED POLYMERS (MIPS)... 

Lanza, F. Sellergren B., Method for synthesis and screening of large groups of molecularly imprinted polymers, Anal. Chem. 1999, 71, 2092-2096... 

Lanza, F. Hall, A.J. Sellergren, B. Bereczki, A. Horvai, G. Bayoudh, S. Cormack, P. A. G. Sherrington D.C., Development of a semiautomated procedure for the synthesis and evaluation of molecularly imprinted polymers applied to the search for functional monomers for phenytoin and nifedipine, Anal. Chim. Acta. 2001, 435, 91-106... 

Chianella, I. Karim, K. Piletska, E. V. Preston, C. Piletsky, S. A., Computational design and synthesis of molecularly imprinted polymers with high binding capacity for pharmaceutical applications-model case Adsorbent for abacavir, Anal. Chim. Acta. 2006, 559, 73-78... 

Piletsky, S. Piletska, E.V. Karim, K. Foster, G. Legge, C. Turner, A. P. F., Custom synthesis of molecular imprinted polymers for biotechnological application Preparation of a polymer selective for tylosin, Anal. Chim. Acta. 2004, 504, 123-130... 

Kempe, H. Kempe, M., Novel methods for the synthesis of molecularly imprinted polymer bead libraries, Macromol. Rapid Commun. 2004, 25, 315-320... 

Cederfur, J. Pei, Y. Meng, Z. Kempe, M., Synthesis and screening of a molecularly imprinted polymer library targeted for penicillin G, J. Combin. Chem. 2003, 5, 67-72... 

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