Molecularly imprinted polymer beads

Ansell, RJ Mosbach, K, Magnetic Molecularly Imprinted Polymer Beads for Drug Radioligand Binding Assay, Analyst 123, 1611, 1998. 

Kempe, H. Kempe, M., Novel methods for the synthesis of molecularly imprinted polymer bead libraries, Macromol. Rapid Commun. 2004, 25, 315-320... 

The stereoselective release behaviors of low-swelling molecularly imprinted polymer bead matrices in pressed-coat tablets were studied using either R- or S-propranolol selective MIPs. The in vitro release profiles of the low-swelling matrices showed a difference in the release of enantiomers, in that the nontemplate isomer was released faster than the template isomer. However, in the last phase of dissolution this difference was reduced and later reversed [64]. Stereoselectivity of release profiles for propranolol enantiomers were identified in MIP synthetic membranes from tablet formulations with significant differences between enantiomers [65]. Release of the enantiomer used as the print was always faster than the... 

Mayes, A. G., Mosbach, K. (1996). molecularly imprinted polymer beads Suspension polymerization using a liquid perfluorocarbon as the dispersing phase. Ana/. Chem.. 68, 3769-3774. 

Instead of making molecularly imprinted polymer beads directly, different methods have been developed to graft an MIP layer on preformed spherical particles to give... 

Figure 9 Common preparation methods for making molecularly imprinted polymer beads and the size range of the product beads. A general comment (+ pro con) on the different methods is included.

Ansell, R.J. Mosbach, K. Magnetic molecularly imprinted polymer beads for drug radioligand binding assay. Analyst 1998,123, 1611-1616. 

Figure 7.6. Beail diameter as a function of the amount of the stabilizing polymer (PFPS) added during a standard polymerization containing 1.84 g EGDMA, 0.16 gof MAA, 4.2 g of chloroform, and 20 mg of AIBN emulsified in 20 ml of perfluoro(methylcyclohexane). Reprinted with permission from Mayes AG, Mosbach K. Molecularly imprinted polymer beads Suspension polymerization using a liquid perfluorocarbon as the dispersing phase. Anal Chem 1996 68 3769-3774.

H. Kempe and M. Kempe, Development and evaluation of spherical molecularly imprinted polymer beads. Ana/. Chem., 78 (11) 3659-3666,2006. 

M. Zourob, S. Mohr, A.G. Mayes, A. Macaskill, N. P rez-Moral, P.R. Fielden and N.J. Goddard, A micro-reactor for preparing uniform molecularly imprinted polymer beads. 

Z. Chen, R. Zhao, D. Shangguan and G. Liu, Preparation and evaluation of uniform-sized molecularly imprinted polymer beads used for the separation of sulfamethazine, Biomed. Chromatogr., 19 (7) 533-538,2005. 

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