SYNGEN

The retrosynthetic analysis is performed in two steps in a first step, SYNGEN dissects the skeleton to find all fully convergent bondsets which utili2e starting material skeletons found in two successive levels of cuts. A bondset is a set of skeletal bonds that is cut during the retrosynthetic analysis or formed in any given synthesis. 

P9] http //syngen2.chem.brandeis.edu/ syngen.html (last update May 21, 2001). 

Walker CM, Levy JA (1989) A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication. Immunology 66 628-630 Walker RE, Bechtel CM, Natarajan V, Baseler M, Hege KM, Metcalf JA, Stevens R, Hazen A, Blaese RM, Chen CC, Lehman SF, Palensky J, Wittes J, Davey RT, Falloon J, Polls MA, Ko-vacs JA, Broad DF, Levine BL, Roberts MR, Masur H, Lane HC (2000) Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. Blood 96 467 74... 

Schroit, A. J., and Key, M. E. (1983). Induction of syngeneic tumor-specific immunity by liposomes reconstituted with L2C tumor-cell antigens, Immunology. 49. 431-438. 

For an allogeneic HCT, the recipient and the donor are dissimilar genetically unless they are identical twins (referred to as a syngeneic HCT). The tissue transplanted is immunologi-cally active, and thus there is potential for bidirectional graft... 

In one of the Canterbury Tales, Chaucer gave the name Placebo to a sycophantic character, and in another (The Parson s Tale) he wrote that Flatereres been the develes chapelleyns, that syngen evere placebo (flatterers are the Devil s chaplains, always singing Placebo).3... 

Kerkvliet, N.I. and Baecher-Steppan, L., Immunotoxicology studies on lead Effects of exposure on tumor growth and cell-mediated immunity after syngeneic or allogeneic stimulation, Immunopharmacology 4, 213, 1982. 

As mentioned above, the early studies of Kripke found that exposure to sub-carcinogenic doses of UV radiation suppresses the immune response of recipient mice and allows for the progressive growth of transplanted UV-induced regressor tumors.2 Adoptive transfer of antigen-specific T lymphocytes78could transfer the immune suppression to normal syngeneic recipient mice. 

Resistance assays, general condition Implantation of syngeneic tumors, bacterial, viral, and parasitic infection Occurrence of sentinel disease (infection, neoplasia), growth indices, respiration rates, heart... 

Yung, R. et al., Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice, J. Clin. Invest., 97, 2866, 1996. 

It was demonstrated in the BN rat that mercuric chloride induced a T-dependent polyclonal activation of B cells [181]. Helper/inducer T cells exposed to mercuric chloride either in vivo or in vitro could induce the proliferation of normal autologous T lymphocytes. Normal syngeneic Ia+ cells were necessary for this proliferation [194]. In BN rats lacking T cells, no auto-... 

Host resistance Bacterial models—Listeria monocytogenes (mortality or spleen clearance) Streptococcus species (mortality) Viral models—influenza (mortality) Parasitic models—Plasmodium yoelii (parasitemia) or Trichinella spiralis (muscle larvae counts and worm expulsion) Syngeneic tumor models—PYB6 sarcoma (tumor incidence) B16F10 melanoma (lung burden). 

Administration of Certain Proteases to Animals Enhances Metastasis. Administration of specific proteases to animals has been found to stimulate the production of metastasis. For example, in rabbits, administration of uPA has been found to enhance the metastasis of V2 carcinomas (K11), while in mice, exogenous uPA increased pulmonary metastasis from Lewis lung carcinomas (Tl). Also, infusion of thrombin into syngenic mice stimulated pulmonary metastasis from both colon carcinoma cells and melanoma cells (N5). This enhanced formation of metastasis in the presence of thrombin may result from increased tumor cell-platelet interaction in the presence of the protease (N5). 

Syngeneic Transplant The person donating the bone marrow or stem cell is an identical twin. 

Tomita K, Izumi K, Okabe S Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice. J Pharmacol Sci 2003 93 321-330. 

Nagata Y, et al. Peptides derived from a wild-type murine proto-oncogene c-erbB-2/HER2/neu can induce CTL and tumor suppression in syngeneic hosts. J Immunol 1997 159 1336. 

Figure 4. Accumulation of iron-labeled MSC in the renal cortex. Animals were anesthetized and coronal T 2-weighted gradient echo in vivo magnetic resonance images (MRl) were obtained before (A) and immediately (B) or 3 days (C) after injection of magnetically labeled (iron-dextran) syngeneic mesenchymal stem cells.

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