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Syngeneic tumor cell models

McCay JA. Immunotoxicology syngeneic tumor cell models B16F10 and PYB6. In Methods in Immunotoxicology, Vol 2, edited by Burleson GR, Dean JH, Munson AE, pp. 143-157. New York, NY Wiley-Liss, 1995. [Pg.176]

The efficacy of a cell-based tumor therapy using MIDGE vectors for transfection of tumor cells in combination with dSLIM immunomodulators was demonstrated in a mouse model of ALL [58]. In this tumor model, the syngeneic pre-B-ALL leukemia cell line BM185 was used to inoculate tumors in mice, with naive mice developing tumors of 20 mm diameter within 3 weeks. [Pg.216]

Depletion of JARIDIB inhibits proliferation of breast cancer cell lines and tumor growth in a syngeneic mouse mammary tumor model. [Pg.273]

We tested the effect of LPS in a model of peritoneal carcinomatosis (solid tumor) induced by PROb colon cancer cells in syngeneic BDEX rats. We showed that i.p. injections of LPS from E. coli can cure 20 % of the rats [157], Comparing the effect of LPS from different strains in this model, we found that the efficacy depends on the bacterial strain and on the structure of the lipid A used. Whatever the lipid A used, we have shown a correlation with in vitro macrophage secretion of IL-ip but not with NO, TNF-a or IL-6 [83],... [Pg.533]

When crude endotoxin from the heptose-less mutant of Salmonella typhimurium is combined with trehalose dimycolate from mycobacteria in oil droplets and injected directly into established tumors (line 10 hepatocellular carcinoma) in syngeneic guinea pigs, rapid regression of the tumors occurs and over 90% of the animals are cured. The three required components for activity in this tumor model are (a) the endotoxin (b) the mycobacterial adjuvant, trehalose dimycolate and (c) a compound satisfying the minimal structural requirement (muramyl dipeptide) for adjuvant activity by bacterial cell wall materials. The mycobacterial cell wall skeleton is able to replace the latter two components. [Pg.219]


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See also in sourсe #XX -- [ Pg.172 ]




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