Survivin gene

Figure 4 Structures of small molecule inhibitors of (a, b) CDK, (c) HSP90, (d) survivin gene expression, (e-l) XIAP, and (m) omi/HtrA2. (a) flavopiridol, (b) purvalanol, (c) 5-aminoimidazole-4-carboxamide-1 -beta-D-ribofuranoside (AlCAR), (d) YM155, (e-h) SMAC-mimetics, (i) Smac mimetic tetrazoyl thioether, (j) benzoquinone embelin, (k) aryl sulfonamide, (I) XIAP inhibitor of Polyphenylurea series, (m) Omi/HtrA2 inhibitor Ucf-101.

Survivin gene Cell culture (Endogenous gene) Cancer (9)... 

Quercetin reduced beta-catenin/TCF transcriptional activity by about 18-fold cyclin D(1) and the survivin gene were downregulated in a dose-dependent manner at both the transcription and protein expression levels... 

Researchers suggest that co-administration or sequential gene therapy with VEGF, Bcl-2, and survivin can enhance myocardial collateral blood vessel function. 

Levicar N, Dewey RA, Daley E, Bates TE, Davies D, Kos J, Pilkington GJ, Lah TT (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor ceU invasion in vitro and promotes apoptosis. Cancer Gene Ther 10 141-151 Levicar N, Strojnik T, Kos J, Dewey RA, Pilkington GJ, Lah TT (2002) Lysosomal enzymes, cathepsins in brain tumour invasion. J Neurooncol 58 21-32 Li F, Ackermann EJ, Bennett CF (1999) Pleiotropic cell-division defects and apoptosis induced by interference with survivin function. Nat Cell Biol 1 461 66 Lopes MBS, VandenBerg SR, Scheithauer BW (1993) The World Health Organization classification of nervous system tumors in experimental neuro-oncology. In AJ Levine and HH Schmidek, eds Molecular Genetics of Nervous System Tumors. Wiley-Liss, New York, NY, pp 1-36... 

Zaffaroni N, et al. Expression of the anti-apoptotic gene survivin 110. correlates with taxol resistance in human ovarian cancer. Cell... 

Fig. 1 The human IAP protein family. Human IAP proteins contain one or three baculovirus IAP repeat (BIR) domains. Several IAP family members also have RING (really interesting new gene) and UBA (ubiquitin associated) domains. The c-IAPl and C-IAP2 proteins each contain a caspase recruitment domain (CARD). Survivin contains a coiled coil domain NAIP has NACHT (domain present in NAIP, CIITA, HET-E, TP1) and leucine rich repeat (LRR) domains Apollon possesses a ubiquitin conjugating (UBC) domain...

Genes Implicated (Through Altered Expression/Association) Survivin, XIAP, bcl-2, bcl-Xl, Al, cIAP2 Survivin (A)... 

In cultured tumor cells, resistance to taxanes is associated in some lines with increased expression of the mdr-1 gene and its product, the P-glycoprotein other resistant cells have P-tubulin mutations, and these latter cells may display heightened sensitivity to vinca alkaloids. Other cell lines display an increase in survivin, an antiapoptotic factor or aurora kinase, an enzyme that promotes completion of mitosis. The basis of clinical drug resistance is not known. Cell death occurs by apoptosis, but the effectiveness of paclitaxel against experimental tumors does not depend on an intact p53 gene product. 

Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997 3 917-921. 

Mesri M, Wall NR, Li J, Kim RW, Altieri DC. Cancer gene therapy using a survivin mutant adenovirus. J Clin Invest 2004 108 981-990. 

Chen IS, Liu JC, Shen L et al. Cancer-specific activation of the survivin promoter and its potential use in gene therapy. Cancer Gene Ther 2004 11 740-747. 

Ulasov IV, Zhu ZB, Tyler MA, Han Y, Rivera AA, Khramtsov A et al. Survivin-driven and fiber-modified oncolytic adenovirus exhibits potent antitumor activity in established intracranial glioma. Hum Gene Ther 2007 18 589-602. 

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