Survivin

Chang CC, Heller JD, Kno J, Hnang RC. (2004) Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression. Proc Natl Acad Sci USA 101 13239-13244. 

De Schepper, S., Bmwiere, H., Verhulst, T., Steller, U., Andries, L., Wouters, W. et al. (2003) Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin. The Journal of Pharmacology and Experimental Therapeutics, 304, 881-888. 

Honda R, Korner R, Nigg EA (2003) Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell 14 3325-3341... 

Granziero L, Ghia P, Circosta P et al (2001) Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood 97 2777-2783... 

Altieri, D.C. 2003. Validating survivin as a cancer therapeutic target. Nat. Rev. Cancer 3, 46-54. Alvarez, J.G. and Storey, B.T. 1983. Taurine, hypotaurine, epinephrine and albumin inhibit lipid peroxidation in rabbit spermatozoa and protect against loss of motility. Biol. Reprod 29, 548-555. Ambani, L.M., Van Woert, M.H., and Murphy, S. 1975. Brain peroxidase and catalase in Parkinson s disease. Arch. Neurol. 32, 114-118. 

Morinaga, S., Nakamura, Y., Ishiwa, N., Yoshikawa, T., Noguchi, Y., Yamamoto, Y., Rino, Y., Imada, T., Takanashi, Y., Akaike, M., Sugimasa, Y., and Takemiya, S. 2004. Expression of survivin mRNA associates with apoptosis, proliferation and histologically aggressive features in hepatocellular carcinoma. Oncol. Rep. 12, 1189-1194. 

Shariat, S.F., Lotan, Y., Saboorian, H., Khoddami, S.M., Roehrbom, C.G., Slawin, K.M., and Ashfaq, R. 2004. Survivin expression is associated with features of biologically aggressive prostate carcinoma. Cancer 100, 751-757. 

Span, P.N., Sweep, F.C., Wiegerinck, E.T., Tjan-Heijnen, V.C., Manders, P., Beex, L.V., and de Kok, J.B. 2004. Survivin is an independent prognostic marker for risk stratification of breast cancer patients. Clin. Chem. 50, 1986-1993. 

LY2181308 Survivin Cancer Intravenous lilly/Isis... 

Studies by Kawata et al. (2001) showed that ischemic preconditioning (IP) enhances the expression of VEGF mRNA in ischemic cardiac myocytes and vascular ECs. They observed increase in capillary density in the infarcted area and a reduction in infarct size, 3 days after the onset of AMI preceded by IP. Several recent studies also provide evidence for an increased expression of VEGF triggered by IP (Fukuda et al. 2004). When rats with chronic MI were subjected to IP, an induction of survival factors including VEGF, Bcl-2, and survivin was observed (Fukuda et al. 2004). 

Researchers suggest that co-administration or sequential gene therapy with VEGF, Bcl-2, and survivin can enhance myocardial collateral blood vessel function. 

Tran, J., Rak, J., Sheehan, C., Saibil, S. D., LaCasse, E., et al. 1999. Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells. Biochem. Biophys. Res. Commun. 264 781-788. 

Fortugno, P. et al. 2003. Regulation of survivin function by Hsp90. Proc. Natl. Acad. Sci. USA 100, 13791-13796. 

Suriawinata, A. 2004. Survivin apoptosis inhibitor and its regulation by Hsp90. Lab. Invest. 84, 395-403. 

Prognostic markers allow prediction of the disease process [e.g., survivin expression in pancreatic cancer patients (Kami et al., 2004)]. 

Wada, M., Miyatake, S., Imamuea, M. (2004). Survivin expression is a prognostic marker in pancreatic cancer patients. Surgery 136, 443 148. 

Levicar N, Dewey RA, Daley E, Bates TE, Davies D, Kos J, Pilkington GJ, Lah TT (2003) Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor ceU invasion in vitro and promotes apoptosis. Cancer Gene Ther 10 141-151 Levicar N, Strojnik T, Kos J, Dewey RA, Pilkington GJ, Lah TT (2002) Lysosomal enzymes, cathepsins in brain tumour invasion. J Neurooncol 58 21-32 Li F, Ackermann EJ, Bennett CF (1999) Pleiotropic cell-division defects and apoptosis induced by interference with survivin function. Nat Cell Biol 1 461 66 Lopes MBS, VandenBerg SR, Scheithauer BW (1993) The World Health Organization classification of nervous system tumors in experimental neuro-oncology. In AJ Levine and HH Schmidek, eds Molecular Genetics of Nervous System Tumors. Wiley-Liss, New York, NY, pp 1-36... 

Mellai M, Caldera V, Patrucco A, Annovazzi L, Schiffer D (2008) Survivin expression in glioblastomas correlates with proliferation, but not with apoptosis. Anticancer Res 28 109-118 Mourelatos Z (2008) MicroRNAs biology and roles in neurodegeneration and brain tumours. 

Bir Domain Family Human Survivin Apoptosis 1F3H Cysft 2 CysL 16 HiSa 6 CysL... 

Mouse Survivin Apoptosis 1M4M Cys/i 2 CyS2a/i 16 His 6 CysL... 

Dan, H.C., Jiang, K., Coppola, D., Hamilton, A., Nicosia, S.V., Sebti, S.M., and Cheng, J.Q. (2004). Phosphatidylinositol-3-QH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. Oncogene 23 706-715. 

The inhibitor of apoptosis proteins (lAPs), which are characterized by the presence of one or more baculovirus lAP repeat (BIR) domains, are a family of endogenous apoptosis inhibitors that possess multiple antiapoptotic activities, including binding and inhibition of active caspases 3, 7, and 9. By inhibiting the downstream caspases 3 and 7, lAPs block the convergence point of multiple caspase activation pathways and thus inhibit apoptosis induced by various stimuli (81). At least eight human lAP members have been identified, of which XIAP (X-linked lAP) and survivin have received the most attention as therapeutic targets (82). 

---