Surface induced dissociation SID

Surface-induced dissociation (SID) is an extremely fast activation technique where precursor ions are m/z-sclcctivcly accelerated and collided with a solid surface. The amount... 

This paper focuses on special ionization methods such as secondary ion MS (SIMS) (1, 13, 24-28) and ZCf plasma desorption (PD), and on MS/MS methods for characterizing primary ions, such as surface induced dissociation (SID), laser photodissociation, and neutralization of multiply charged ions. A Hadamard transform method for more efficient recording of multiple MS-II spectra is also proposed. 

Another activation method, which is performed without gas, uses collisions with a solid surface [22,23], This method is called surface-induced dissociation (SID). In practice,... 

Figure 10. Surface-induced dissociation (SID) profiles for naphthalene (CtoHi ) including signal due to pick-up of one or more methyl groups firom the surface,...

Cr (CO)6 and protonated peptide surface induced dissociation (SID) AMI Shattering fragmentation, apparent non-RRKM dynamics [123-125]... 

Being a trapped ion technique, FTMS has always had the potential to allow MS/MS studies to investigate polymer structure. Flowever, to date, there are relatively few literature reports of pol5mer structure studies. It is often found that direct dissociation of polymers is a difficult problem. Current metliods for high-mass ion activation have met with limited success. For example, there has been little work done by surface-induced dissociation (SID), and collision-induced dissociation (CID) is known not to work well for singly charged ions... 

Fragmentation of peptide and protein ions in FT-ICR mass spectrometry may be induced by sustained off-resonance irradiation collision-induced dissociation (SORI-CID) [28], infrared multiphoton dissociation (IRMPD) [29,30], blackbody infrared radiative dissociation (BIRD) [31,32], surface-induced dissociation (SID) [33,34], and electron capture dissociation (ECD) [35,36]. These techniques are true MS/MS techniques in which the precursor ion is isolated prior to fragmentation. Additional techniques in which ions are not isolated but fragmented before they... 

Ion activation is also accomplished by collisions of the fast-moving precursor ions with a solid surface [12,13]. This ion-surface collision technique, known as surface-induced dissociation (SID), can be implemented on a variety of tandem mass spectrometry systems, such as magnetic sector, TOF, quadrupoles, ion traps, and FT-ICR-MS, by placing a solid surface in the path of the ions [13]. The surface can be a bare metal (e.g., a stainless-steel plate) or a metal covered with self-assembled monolayers [14]. Ion-surface collisions are more efficient in terms of internal energy conversion because of the greater mass of the colliding surface [see Eq. (4.4)]. Consequently, compared to the CID process, in which a serious decrease in the dissociation efficiency is observed, ions of much higher mass can... 

Other methods of activation of stable ions are used in structural analysis. The ions can be collided with a surface (surface-induced dissociation, SID), reacted with electrons, or subjected to photodissociation. ... 

In addition, new tandem mass spectrometry technologies were also among the important innovations. Apart from traditional collision-induced dissociation (CID) [89-91], a variety of activation methods (used to add energy to mass-selected ions) based on inelastic collisions and photon absorption have been widely utilized. They include IR multiphoton excitation [92,93], UV laser excitation [94—97], surface-induced dissociation (SID) [98-100], black body radiation (101, 102], thermal dissociation [103], and others. As the fragmentation of peptide/protein ions is a central topic in proteomics, there is strong interest in such novel ion dissociation methods as electron capture dissociation (ECD) [104, 105] and electron transfer dissociation [22]. These new methods can provide structural information that complements that obtained by traditional collisional activation. Also, very recently, ambient ion dissociation methods such as atmospheric pressure thermal dissociation [106] and low temperature plasma assisted ion dissociation [107] have been reported. 

Another type of interaction is surface-induced dissociation (SID), in which precursor ions interact with a surface to induce dissociation. Ions have been reflected off cell walls or trapping plates to increase their internal... 

TOF-RTOF instruments. An alternative approach to reacceleration uses a reflec-tron in MS2 to disperse the product-ion arrival times in the same manner as used for the post-source decay method. Additionally, the reflectron can be used in combination with reacceleration after the collision chamber. In the TOF-RTOF instrument reported by Cooks et al. (Figure 9.6), ion activation is provided by surface-induced dissociation (SID), and product ions are dispersed and focused by a reflectron. The target surface is raised to a potential above the drift region, so that product ions are dispersed by reacceleration as well. The effect of this combination is to... 

Fig. 26. Tandem MS/MS spectra of protonated (V-acetyl OMe proline obtained using different ion-activation methods and instruments, such as gas-phase collisional activation in (a) a Thermoelectron (Finnigan) LCQ classic 3D QIT instrument, (b) a Thermoelectron (Finnigan) triple quadrupole (QQQ) instrument, and (c) surface-induced dissociation (SID) in a Micromass Q-TOF instrument.

Analytical tandem mass spectrometry (MS/MS) relies on the ability to activate and dissociate ions in order to identify or obtain structural information about an unknown compound. The most common means of ion activation in tandem mass spectrometry is collision-induced dissociation (CID). CK) uses gas phase collisions between the ion and neutral target gas to cause internal excitation of the ion and subsequent dissociation. Surface-induced dissociation (SID) is analogous to the CID experiment except a surface is substituted for the collision gas as shown in Figure 1. SID offers several advantages as a means... 

Surface-induced dissociation (SID) ° is an important experimental tool for determining structural properties of ions and energetic and mechanistic information concerning their dissociation pathways. In SID the ion is energized by collision with a surface. If electronic excitation is unimportant, the collision translational energy E, is partitioned between the final translational energy Ef, and transfer to the internal vibrational/rotational modes of the ion AEint and the vibrations of the surface... 

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